Reducing the toxicity of amphotericin B by encapsulation using methoxy poly(ethylene glycol)-b-poly(l-glutamic acid-co-l-phenylalanine)

2018 ◽  
Vol 6 (8) ◽  
pp. 2189-2196 ◽  
Author(s):  
Chenguang Yang ◽  
Baiji Xue ◽  
Wantong Song ◽  
Bo Kan ◽  
Dawei Zhang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Amphotericin B ◽  
Fungal Infections ◽  
Antifungal Drug ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Amphotericin B (AmB) is an antifungal drug used for serious fungal infections and leishmaniosis.

Poly(γ-glutamic acid) modulates the properties of poly(ethylene glycol) hydrogel for biomedical applications

2016 ◽  
Vol 27 (18) ◽  
pp. 1775-1787 ◽  
Author(s):  
Weikang Hu ◽  
Xiaoreng Feng ◽  
Xin Liu ◽  
Shulin Dai ◽  
Wen Zeng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Patupilone-loaded poly(L-glutamic acid)-graft-methoxy-poly(ethylene glycol) micelle for oncotherapy

2017 ◽  
Vol 28 (4) ◽  
pp. 394-414 ◽  
Author(s):  
Jing Yan ◽  
Dawei Zhang ◽  
Haiyang Yu ◽  
Lili Ma ◽  
Mingxiao Deng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Y-shaped block copolymer (methoxy-poly(ethylene glycol))2-b-poly(l-glutamic acid): preparation, self-assembly, and use as drug carriers

RSC Advances ◽  
2014 ◽  
Vol 4 (78) ◽  
pp. 41588-41596 ◽  
Author(s):  
Lixin Yang ◽  
Xiuli Hu ◽  
Weiqi Wang ◽  
Shi Liu ◽  
Tingting Sun ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Solid Tumors ◽  
Self Assembly ◽  
Drug Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Polymer Drugs

The nano polymer drugs based on Y-shaped block copolymer mPEG2-PGA show a great potential on the treatment for solid tumors.

Copolymer Nanoparticles Prepared by Self-Assembly of Poly(ethylene glycol) and Poly-γ-Glutamic Acid and its Characteristics

2013 ◽  
Vol 662 ◽  
pp. 136-139
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Poly Ethylene Glycol ◽  
Polyelectrolyte Complexes ◽  
Self Assembling ◽  
Transmission Electron ◽  
Poly Ethylene

The paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and poly(ethylene glycol) (PEG). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic lightscattering and transmission electron microscopy.It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and PEG solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 30–270 nm. measured by TEM, and the average hydrodynamic diameters were between 130 and 300 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

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