Copolymer Nanoparticles Prepared by Self-Assembly of Poly(ethylene glycol) and Poly-γ-Glutamic Acid and its Characteristics

2013 ◽  
Vol 662 ◽  
pp. 136-139
Author(s):  
Ge Yang ◽  
Ke Shuai Lu ◽  
Xue Yan Su
Keyword(s):  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Size Distribution ◽  
Self Assembly ◽  
Aqueous Media ◽  
Poly Ethylene Glycol ◽  
Polyelectrolyte Complexes ◽  
Self Assembling ◽  
Transmission Electron ◽  
Poly Ethylene

The paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-gamma-glutamic acid (γ-PGA) and poly(ethylene glycol) (PEG). The nanosystems were stable in aqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. The particle size and the size distribution of the polyelectrolyte complexes were identified by dynamic lightscattering and transmission electron microscopy.It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA and PEG solutions and their ratio as well as on the pH of the mixture and the order of addition. The diameter of individual particles was in the range of 30–270 nm. measured by TEM, and the average hydrodynamic diameters were between 130 and 300 nm. These biodegradable, self-assembling stable nanocomplexes might be useful for several biomedical applications.

Y-shaped block copolymer (methoxy-poly(ethylene glycol))2-b-poly(l-glutamic acid): preparation, self-assembly, and use as drug carriers

RSC Advances ◽  
2014 ◽  
Vol 4 (78) ◽  
pp. 41588-41596 ◽  
Author(s):  
Lixin Yang ◽  
Xiuli Hu ◽  
Weiqi Wang ◽  
Shi Liu ◽  
Tingting Sun ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Solid Tumors ◽  
Self Assembly ◽  
Drug Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Polymer Drugs

The nano polymer drugs based on Y-shaped block copolymer mPEG2-PGA show a great potential on the treatment for solid tumors.

Synthesis and Self-Assembly Study of Biodegradable Amphiphilic Triblock Copolymers with PEG Block

2014 ◽  
Vol 998-999 ◽  
pp. 95-98
Author(s):  
Xu Du ◽  
Qin Wang ◽  
Chuan Dong Wang ◽  
Yang Liu
Keyword(s):  
Electron Microscopy ◽  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Chemical Structures ◽  
Transmission Electron ◽  
Spherical Micelles ◽  
Poly Ethylene

Three biodegradable amphiphilic triblock copolymers: polylactide-poly (ethylene glycol)-polylactide (PLA-PEG-PLA), poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG-PCL) and poly (lactide-glycolide)-poly (ethylene glycol)-poly (lactide-glycolide) (PLGA-PEG-PLGA) were synthesized. Their chemical structures were characterized. In aqueous solution, their self-assembly and degradation were studied by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Spherical micelles were formed in aqueous solution via self-assembly of the amphiphilic triblock copolymers. After degradation, the PLA-PEG-PLA and PCL-PEG-PCL micelles became smaller and the PLGA-PEG-PLGA micelles change to vesicles, which should mainly attribute to their different degradation speed.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Synthesis of Fluorescent Magnetic and Plasmonic-Hybrid Multifunctional Nanopaticles

2014 ◽  
Vol 1081 ◽  
pp. 161-164
Author(s):  
Xue Mei Li ◽  
Zheng Guan ◽  
Hong Ling Liu ◽  
Jun Hua Wu ◽  
Xian Hong Wang ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Zno Nanoparticles ◽  
Poly Ethylene Glycol ◽  
Visible Absorption ◽  
Transmission Electron ◽  
Good Magnetic Property ◽  
Uv Visible ◽  
Poly Ethylene ◽  
Poly Propylene

FeAu/ZnO nanoparticles were successfully synthesized by nanoemulsion process with the use of poly (ethylene glycol)-block-poly (propylene glycol)-block-poly (ethylene glycol) as the surfactant. The characterization of the FeAu/ZnO nanoparticles was performed using X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and UV-visible absorption spectroscopy, showing that the polymer-laced nanoparticles reveal high crystallinity, excellent dispersibility and well defined optical performance. The process of solvent dispersion-collection of FeAu/ZnO nanoparticles indicates that the nanoparticles possess good magnetic property for applications.

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