Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

2018 ◽  
Vol 54 (82) ◽  
pp. 11586-11589
Author(s):  
Jeong Yu Lee ◽  
Ho Yeon Son ◽  
Jae Chul Park ◽  
Jongnam Park ◽  
Yoon Sung Nam
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Three Dimensional ◽  
Superparamagnetic Iron Oxide ◽  
Hybrid Nanoparticles ◽  
Nanocrystal Superlattices

Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol.

Magnetic nanomedicine for CD133-expressing cancer therapy using locoregional hyperthermia combined with chemotherapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (26) ◽  
pp. 2543-2561
Author(s):  
Shu-Jyuan Yang ◽  
Shu-Yi Tseng ◽  
Chung-Hao Wang ◽  
Tai-Horng Young ◽  
Ke-Cheng Chen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Superparamagnetic Iron Oxide ◽  
Regional Hyperthermia ◽  
Styrene Sulfonate ◽  
Sodium Styrene Sulfonate ◽  
Magnetic Resonance Imaging Contrast ◽  
Weighted Magnetic Resonance Imaging

Aim: Cells with CD133 overexpression, a theoretical cancer stem cells (CSCs) marker, have been shown to induce colorectal cancer (CRC) initiation and relapse. Therefore, the detection and treatment of CSCs are the most important factors in overcoming CRC. Materials & methods: Herein, we developed a magnetite-based nanomedicine (superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticle) using loco-regional hyperthermia combined with chemotherapy for CRC- and CSC-specific targeting treatment. Results: The designed nanoparticles were highly biocompatible and exhibited a higher temperature increase rate under radiofrequency generator irradiation. The nanoparticles could be used as a T2-weighted magnetic resonance imaging contrast media, and also applied during hyperthermia and chemotherapy to display a synergistic anticancer effect. Conclusion: Therefore, the superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticles are a powerful candidate for future antitumor strategies.

Monitoring the self-assembly of chitosan/glutaraldehyde/cysteamine/Au-colloid and the binding of human serum albumin with hesperidin

Biomaterials ◽  
2004 ◽  
Vol 25 (26) ◽  
pp. 5725-5733 ◽  
Author(s):  
Yingju Liu ◽  
Yanling Li ◽  
Shanchao Liu ◽  
Jia Li ◽  
Shouzhuo Yao
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
The Self

scholarly journals Three-dimensional structure of human serum albumin

Science ◽  
1989 ◽  
Vol 244 (4909) ◽  
pp. 1195-1198 ◽  
Author(s):  
D. Carter ◽  
X. He ◽  
S. Munson ◽  
P. Twigg ◽  
K. Gernert ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Three Dimensional Structure
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