Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

2013 ◽  
Vol 31 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Quazi T. H. Shubhra ◽  
Andrea F. Kardos ◽  
Tivadar Feczkó ◽  
Hana Mackova ◽  
Daniel Horák ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Superparamagnetic Iron Oxide ◽  
Plga Nanoparticles ◽  
Process Variables ◽  
Mean Size ◽  
The Mean

Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

2018 ◽  
Vol 54 (82) ◽  
pp. 11586-11589
Author(s):  
Jeong Yu Lee ◽  
Ho Yeon Son ◽  
Jae Chul Park ◽  
Jongnam Park ◽  
Yoon Sung Nam
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Three Dimensional ◽  
Superparamagnetic Iron Oxide ◽  
Hybrid Nanoparticles ◽  
Nanocrystal Superlattices

Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol.

Magnetic nanomedicine for CD133-expressing cancer therapy using locoregional hyperthermia combined with chemotherapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (26) ◽  
pp. 2543-2561
Author(s):  
Shu-Jyuan Yang ◽  
Shu-Yi Tseng ◽  
Chung-Hao Wang ◽  
Tai-Horng Young ◽  
Ke-Cheng Chen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Superparamagnetic Iron Oxide ◽  
Regional Hyperthermia ◽  
Styrene Sulfonate ◽  
Sodium Styrene Sulfonate ◽  
Magnetic Resonance Imaging Contrast ◽  
Weighted Magnetic Resonance Imaging

Aim: Cells with CD133 overexpression, a theoretical cancer stem cells (CSCs) marker, have been shown to induce colorectal cancer (CRC) initiation and relapse. Therefore, the detection and treatment of CSCs are the most important factors in overcoming CRC. Materials & methods: Herein, we developed a magnetite-based nanomedicine (superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticle) using loco-regional hyperthermia combined with chemotherapy for CRC- and CSC-specific targeting treatment. Results: The designed nanoparticles were highly biocompatible and exhibited a higher temperature increase rate under radiofrequency generator irradiation. The nanoparticles could be used as a T2-weighted magnetic resonance imaging contrast media, and also applied during hyperthermia and chemotherapy to display a synergistic anticancer effect. Conclusion: Therefore, the superparamagnetic iron oxide@poly(sodium styrene sulfonate)/irinotecan/human serum albumin-anti-CD133 nanoparticles are a powerful candidate for future antitumor strategies.

RADIOIMMUNOASSAYS OF 3,5,3′-TRIIODO-L-THYRONINE WITH AND WITHOUT A PRIOR EXTRACTION STEP

1975 ◽  
Vol 80 (1) ◽  
pp. 58-69 ◽  
Author(s):  
A. Burger ◽  
C. Sakoloff ◽  
V. Staeheli ◽  
M. B. Vallotton ◽  
S. H. Ingbar
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Normal Values ◽  
Covalent Binding ◽  
Extraction Procedure ◽  
Mixed Population ◽  
Coupling Agents ◽  
Extraction Step ◽  
The Mean

ABSTRACT Two radioimmunoassays for triiodothyronine (T3) are described, one of which includes an extraction step, while the other does not. To raise antibodies, two carrier proteins and different coupling agents were used, namely haemocyanin and diazotized benzidine or human serum albumin and carbodiimide. In the case of T3 coupled to haemocyanin by diazotized benzidine, evidence of covalent binding of the hapten to the protein was obtained. In the case of T3 coupled to human serum albumin, little evidence of covalent linkage was available. Nevertheless immunization was successful in both cases. The radioimmunoassay in unextracted serum was highly reproducible and precise (intra-assay variability 5.2% inter-assay variability 8.1%). Normal values were determined which clearly indicate a fall in the serum T3 concentration with increasing age. In men the fall occurs in the fifth decade. In women the T3 starts to fall only after 70 years of age. In 31 cases of hyperthyroidism the serum T3 concentration ranged from 2.26 to 10.4 ng T3/ml. In 10 cases of hypothyroidism the values ranged from 0 to 0.8 ng T3/ml. The radioimmunoassay using an extraction procedure was less extensively used since it was found to be less reproducible (intra-assay variability 7.5%, inter-assay 12.25%). The normal values were determined with a mixed population aged 20–50. The mean ± 2 sd was 0.9 ± 0.36 ng T3/ml (n=52). In 17 cases of hypothyroidism the values ranged from 0 to 0.6 ng T3/ml and in 22 cases of hyperthyroidism from 2 to 14.4 ng T3/ml.

scholarly journals Surface modification of PLGA nanoparticles via human serum albumin conjugation for controlled delivery of docetaxel

2013 ◽  
Vol 21 (1) ◽  
Author(s):  
Saeed Manoochehri ◽  
Behrad Darvishi ◽  
Golnaz Kamalinia ◽  
Mohsen Amini ◽  
Mahdieh Fallah ◽  
...  
Keyword(s):  
Surface Modification ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Plga Nanoparticles ◽  
Controlled Delivery
Sign in / Sign up

Export Citation Format

Share Document