scholarly journals Hyperbranched poly(ethylenimine-co-oxazoline) by thiol–yne chemistry for non-viral gene delivery: investigating the role of polymer architecture

2019 ◽  
Vol 10 (10) ◽  
pp. 1202-1212 ◽  
Author(s):  
Alexander B. Cook ◽  
Raoul Peltier ◽  
Junliang Zhang ◽  
Pratik Gurnani ◽  
Joji Tanaka ◽  
...  

Synthesis of long-chain hyperbranched poly(ethylenimine-co-oxazoline)s by AB2 thiol–yne chemistry is reported, and their application as pDNA transfection agents studied.

2020 ◽  
Vol 20 ◽  
Author(s):  
L. Hajba ◽  
A. Guttman

: Adeno-associated virus (AAV) is one of the most promising viral gene delivery vectors with long-term gene expression and disease correction featuring high efficiency and excellent safety in human clinical trials. During the production of AAV vectors,there are several quality control (QC)parameters that should be rigorously monitored to comply with clini-cal safety and efficacy. This review gives a short summary of the most frequently used AVV production and purification methods,focusing on the analytical techniques applied to determine the full/empty capsid ratio and the integrity of the encapsidated therapeutic DNA of the products.


2002 ◽  
Vol 73 (2) ◽  
pp. 432-437 ◽  
Author(s):  
Uz Stammberger ◽  
Aima N. Uduehi ◽  
Bartosz Kubisa ◽  
Thierry Roth ◽  
Ralph A. Schmid

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