scholarly journals An iRGD peptide conjugated heparin nanocarrier for gastric cancer therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (52) ◽  
pp. 30012-30020 ◽  
Author(s):  
Shichao Ai ◽  
Shuang Zhen ◽  
Zhijian Liu ◽  
Feng Sun ◽  
Xingchen He ◽  
...  

A nontoxic, low immunogenic and high specific drug delivery system for gastric cancer.

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.


2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.


2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu

2020 ◽  
Vol 242 ◽  
pp. 116403 ◽  
Author(s):  
Rana Shafabakhsh ◽  
Bahman Yousefi ◽  
Zatollah Asemi ◽  
Banafsheh Nikfar ◽  
Mohammad Ali Mansournia ◽  
...  

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