scholarly journals Near-infrared fluorescent probes based on TBET and FRET rhodamine acceptors with different pKa values for sensitive ratiometric visualization of pH changes in live cells

2019 ◽  
Vol 7 (2) ◽  
pp. 198-209 ◽  
Author(s):  
Jianbo Wang ◽  
Shuai Xia ◽  
Jianheng Bi ◽  
Yibin Zhang ◽  
Mingxi Fang ◽  
...  

Three near-infrared ratiometric fluorescent probes with different pKa values were synthesized to achieve sensitive ratiometric visualization of pH variations in lysosomes.

2017 ◽  
Vol 5 (48) ◽  
pp. 9579-9590 ◽  
Author(s):  
Mingxi Fang ◽  
Rashmi Adhikari ◽  
Jianheng Bi ◽  
Wafa Mazi ◽  
Nethaniah Dorh ◽  
...  

Five fluorescent probes bearing coumarin moieties with spirolactam ring structures have been developed to detect pH changes in visible and near-infrared channels.


2020 ◽  
Vol 306 ◽  
pp. 127567 ◽  
Author(s):  
Jiemin Wang ◽  
Zhidong Teng ◽  
Ting Cao ◽  
Jing Qian ◽  
Lei Zheng ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1592 ◽  
Author(s):  
Fang ◽  
Xia ◽  
Bi ◽  
Wigstrom ◽  
Valenzano ◽  
...  

Two near-infrared fluorescent probes (A and B) containing hemicyanine structures appended to dipicolylamine (DPA), and a dipicolylamine derivative where one pyridine was substituted with pyrazine, respectively, were synthesized and tested for the identification of Zn(II) ions in live cells. In both probes, an acetyl group is attached to the phenolic oxygen atom of the hemicyanine platform to decrease the probe fluorescence background. Probe A displays sensitive fluorescence responses and binds preferentially to Zn(II) ions over other metal ions such as Cd2+ ions with a low detection limit of 0.45 nM. In contrast, the emission spectra of probe B is not significantly affected if Zn(II) ions are added. Probe A possesses excellent membrane permeability and low cytotoxicity, allowing for sensitive imaging of both exogenously supplemented Zn(II) ions in live cells, and endogenously releases Zn(II) ions in cells after treatment of 2,2-dithiodipyridine.


ACS Sensors ◽  
2017 ◽  
Vol 2 (7) ◽  
pp. 924-931 ◽  
Author(s):  
Shuwei Zhang ◽  
Tzu-Ho Chen ◽  
Hsien-Ming Lee ◽  
Jianheng Bi ◽  
Avik Ghosh ◽  
...  

2013 ◽  
Vol 1 (34) ◽  
pp. 4281 ◽  
Author(s):  
Li Fan ◽  
Qiaoling Liu ◽  
Dongtao Lu ◽  
Heping Shi ◽  
Yunfeng Yang ◽  
...  
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