scholarly journals Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

2020 ◽  
Vol 56 (5) ◽  
pp. 719-722
Author(s):  
Mattia Ghirardello ◽  
Ane Ruiz-de-Angulo ◽  
Nagore Sacristan ◽  
Diego Barriales ◽  
Jesús Jiménez-Barbero ◽  
...  
Keyword(s):  
Molecular Level ◽  
Vaccine Adjuvants ◽  
Adjuvant Activity ◽  
Structure Activity Relationships ◽  
Design And Synthesis ◽  
Structure Activity

This work provides new streamlined saponin vaccine adjuvants and molecular-level insights into saponin conformation that correlate with potent adjuvant activity.

scholarly journals Structure–Activity Relationships Aided Design and Synthesis of xCT Antiporter Inhibitors

ChemMedChem ◽  
2021 ◽  
Author(s):  
Davide Cirillo ◽  
Shahin Sarowar ◽  
Per Øyvind Enger ◽  
Hans-René Bjørsvik
Keyword(s):  
Structure Activity Relationships ◽  
Design And Synthesis ◽  
Structure Activity ◽  
Aided Design

Design and Synthesis of Novel Sulfonamide-Containing Bradykinin hB2Receptor Antagonists. 2. Synthesis and Structure−Activity Relationships of α,α-Cycloalkylglycine Sulfonamides

2007 ◽  
Vol 50 (3) ◽  
pp. 550-565 ◽  
Author(s):  
Daniela Fattori ◽  
Cristina Rossi ◽  
Christopher I. Fincham ◽  
Valerio Caciagli ◽  
Fernando Catrambone ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Design And Synthesis ◽  
Structure Activity

Quantitative Structure-Activity Relationships (QSARs) for Materials Science

2001 ◽  
Vol 700 ◽  
Author(s):  
Krishna Rajan ◽  
Changwon Suh ◽  
Arun Rajagopalan ◽  
Xiang Li
Keyword(s):  
Organic Chemistry ◽  
Materials Science ◽  
Molecular Level ◽  
Combinatorial Synthesis ◽  
Quantitative Structure ◽  
New Materials ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Computational Aspects ◽  
Quantitative Structure Activity Relationships

AbstractThe field of combinatorial synthesis and “artificial intelligence” in materials science is still in its infancy. In order to develop and accelerated strategy in the discovery of new materials and processes, requires the need to integrate both the experimental aspects of combinatorial synthesis with the computational aspects of information based design of materials. In biology and organic chemistry, this has been accomplished by developing descriptors which help to specify “quantitative structure- activity relationships” at the molecular level. If materials science is to adopt these strategies as well, a similar framework of “QSARs” is required. In this paper, we outline some approaches that can lay the foundations for QSARs in materials science.

scholarly journals Design and synthesis of analogues of RA-VII—an antitumor bicyclic hexapeptide from Rubiae radix

2021 ◽  
Author(s):  
Yukio Hitotsuyanagi
Keyword(s):  
Efficient Method ◽  
Core Structure ◽  
Structure Activity Relationships ◽  
Design And Synthesis ◽  
The Core ◽  
Structure Activity ◽  
Tyrosine Derivatives ◽  
Natural Peptides

AbstractThe 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially available l-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure–activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures. Graphic abstract

Sign in / Sign up

Export Citation Format

Share Document