tyrosine derivatives
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2021 ◽  
Author(s):  
Shumin Bao ◽  
Xiaoyan Zhong ◽  
Ying Wan ◽  
Guishan Tan ◽  
Kangping Xu ◽  
...  
Keyword(s):  

Author(s):  
Merve Canlı ◽  
Ecem Evrim Çelik ◽  
Tolgahan Kocadağlı ◽  
Evrim Özkaynak Kanmaz ◽  
Vural Gökmen

2021 ◽  
Vol 19 (9) ◽  
pp. 117-125
Author(s):  
Sabrean Farhan Jawad ◽  
Dr. Nagham Mahmood Aljamali

Cancerous tumors are considered a serious and fatal diseases for both sexes and for all ages, even fetuses before their birth. Therefore, it has become necessary to find an alternative treatment for radiation to be safer and less dangerous than chemical treatments. Therefore, derivatives of one of the amino acids, such as tyrosine, were prepared. Tyrosine or tyrosine is one of the well-known and important amino acids for humans, and it is present in most proteins; The human body uses it to produce several types of hormones such as noradrenaline and adrenaline. In this paper, we prepared new derivatives of tyrosine represented by (four, five, six)-membered ring, then all these new tyrosine derivatives investigated by several techniques (FT.IR, H.NMR)–spectrophotometric, other physical and chemical properties, with assaying for some new created derivatives as anti-cancer.


ChemCatChem ◽  
2021 ◽  
Author(s):  
Sophie Wintermans ◽  
Jordi F. Keijzer ◽  
Marte Dros ◽  
Han Zuilhof ◽  
HB Albada

Author(s):  
Yuhe Shen ◽  
Jiayu Liu ◽  
Yuefei Wang ◽  
Wei Qi ◽  
Rongxin Su ◽  
...  

Author(s):  
Yukio Hitotsuyanagi

AbstractThe 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially available l-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure–activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures. Graphic abstract


Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2916
Author(s):  
Pedro Adão ◽  
João Reboleira ◽  
Marco Teles ◽  
Beatriz Santos ◽  
Nádia Ribeiro ◽  
...  

The chemical modification of porphyran hydrocolloid is attempted, with the objective of enhancing its antioxidant and antimicrobial activities. Sulfated galactan porphyran is obtained from commercial samples of the red algae Porphyra dioica using Soxhlet extraction with water at 100 °C and precipitation with isopropyl alcohol. The extracted porphyran is then treated with modified L-tyrosines in aqueous medium in the presence of NaOH, at ca. 70 °C. The modified tyrosines L1 and L2 are prepared through a Mannich reaction with either thymol or 2,4-di-tert-butylphenol, respectively. While the reaction with 2,4-di-tert-butylphenol yields the expected tyrosine derivative, a mixture of products is obtained with thymol. The resulting polysaccharides are structurally characterized and the respective antioxidant and antimicrobial activities are determined. Porphyran treated with the N-(2-hydroxy-3,5-di-tert-butyl-benzyl)-L-tyrosine derivative, POR-L2, presents a noticeable superior radical scavenging and antioxidant activity compared to native porphyran, POR. Furthermore, it exhibited some antimicrobial activity against S. aureus. The surface morphology of films prepared by casting with native and modified porphyrans is studied by SEM/EDS. Both POR and POR-L2 present potential applicability in the production of films and washable coatings for food packaging with improved protecting characteristics.


2021 ◽  
Vol 96-97 ◽  
pp. S76
Author(s):  
Nils Walter ◽  
Boris Zlatopolskiy ◽  
Heike Endepols ◽  
Bernd Neumaier

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