Oleic acid as a protein ligand improving intestinal absorption and ocular benefit of fucoxanthin in water through protein-based encapsulation

A basal sterol-free diet consisting of casein, 18%; dextrin, 57%; oleic acid, 9%; U.S.P. salt mixture, 2%; yeast, 5%; and cellulose, 9%; along with 1% sulfasuxidine and 0.2% streptomycin sulfate was fed to eight rats during a control period of 12 days, the feces being collected under alcohol the last 4 days and assayed for digitonide sterol. The experiment was repeated with the addition of 28 mg of coprostanol to the diet. It was found that from 41 to 61% (average 48%) of the coprostanol was absorbed. The relation of chemical structure to the absorbability of cholesterol derivatives is discussed with the finding that all absorbable cholesterol derivatives have the ‘chair’ conformation, but are not alike in digitonide formation and Liebermann-Burchard color reaction.

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Effect of soy protein and casein intake on intestinal absorption and lymphatic transport of cholesterol and oleic acid

American Journal of Clinical Nutrition ◽

10.1093/ajcn/40.6.1156 ◽

1984 ◽

Vol 40 (6) ◽

pp. 1156-1164 ◽

Cited By ~ 36

Author(s):

G V Vahouny ◽

W Chalcarz ◽

S Satchithanandam ◽

I Adamson ◽

D M Klurfeld ◽

...

Keyword(s):

Oleic Acid ◽

Intestinal Absorption ◽

Soy Protein ◽

Lymphatic Transport

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Augmenting the cytotoxicity of oleic acid-protein complexes: Potential of target-specific antibodies

Biochimie ◽

10.1016/j.biochi.2017.03.013 ◽

2017 ◽

Vol 137 ◽

pp. 139-146 ◽

Cited By ~ 1

Author(s):

Mehboob Hoque ◽

Jyoti Gupta ◽

M. Saleemuddin

Keyword(s):

Oleic Acid ◽

Protein Complexes ◽

Specific Antibodies ◽

Acid Protein

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An Autoradiographic Study of the Intestinal Absorption of Palmitic and Oleic Acid

Acta Physiologica Scandinavica ◽

10.1111/j.1748-1716.1973.tb05525.x ◽

1973 ◽

Vol 89 (3) ◽

pp. 306-317 ◽

Cited By ~ 18

Author(s):

By Ulf Haglund ◽

Mats Jodal ◽

Ove Lundgren

Keyword(s):

Oleic Acid ◽

Intestinal Absorption ◽

Autoradiographic Study

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A TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DEFERIOXAMINE MESYLATE FOR THE TREATMENT OF BETA-THALASSAEMIA MAJOR

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s1016237211002347 ◽

2011 ◽

Vol 23 (01) ◽

pp. 29-35

Author(s):

Chin-Hsiung Hsieh ◽

Yuan-An Ku ◽

Lien-Hua Chiu ◽

Tai-Horng Young ◽

Yi-You Huang

Keyword(s):

Drug Delivery ◽

Oleic Acid ◽

Iron Overload ◽

Drug Delivery System ◽

Delivery System ◽

Transdermal Delivery ◽

Polysorbate 80 ◽

Thalassaemia Major ◽

Pressure Sensitive Adhesives ◽

Pressure Sensitive

Patients with beta-thalassaemia major need blood transfusion frequently during their whole life. However, frequent transfusions will eventually lead to the accumulation of trivalent iron, resulting in iron overload. To reduce iron overload, patients are administered regularly with intravenous or subcutaneous infusion of deferioxamine mesylate (DFO). Nevertheless, high costs of medication, poor patient compliance, and side effects limit its use and patient's acceptance. To overcome such drawbacks, we developed a novel transdermal delivery system to administer the DFO instead of traditional injections. We assayed the feasibility of fabricating a transdermal DFO patch using the single-layer drug-in-adhesive drug delivery system. We used the pressure-sensitive adhesives and hydrogels as the drug reservoirs and studied the release profile of DFO from the transdermal patches in vitro. In order to enhance the transdermal delivery rate, chemical enhancers, polysorbate 80 and oleic acid, and physical enhancer, ultrasound, were incorporated into the monolith DFO patches. Experimental results showed that the combination of polysorbate 80 and oleic acid in the pressure-sensitive adhesives enhanced the penetration efficiency through nude mice skin. The pretreatment of nude mice skin with ultrasound temporally changed the diffusional resistance and facilitated DFO penetration through the skin. We expect that the new delivery system can enable the drug to penetrate through skin at a stable rate and reach the circulation system successfully, thus allowing the concentration of drug to achieve the therapeutic effect.

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