Chemical repair mechanisms of damaged tyrosyl and tryptophanyl residues in proteins by the superoxide radical anion

2020 ◽  
Vol 44 (6) ◽  
pp. 2505-2513
Author(s):  
Leonardo Muñoz-Rugeles ◽  
Annia Galano ◽  
Juan Raúl Alvarez-Idaboy
Keyword(s):  
Superoxide Anion ◽  
Radical Anion ◽  
Anion Radical ◽  
Superoxide Radical ◽  
Superoxide Anion Radical ◽  
Superoxide Radical Anion ◽  
Diffusion Controlled ◽  
Repair Mechanisms

Even though reaction of the superoxide anion radical/hydroperoxide radical could lead to oxidation of biomolecules, it can repair oxidized tyrosyl and tryptophanyl residues in proteins at diffusion-controlled rates.

The other side of the superoxide radical anion: its ability to chemically repair DNA oxidized sites

2018 ◽  
Vol 54 (97) ◽  
pp. 13710-13713 ◽  
Author(s):  
Leonardo Muñoz-Rugeles ◽  
Annia Galano ◽  
Juan Raúl Alvarez-Idaboy
Keyword(s):  
Superoxide Anion ◽  
Radical Anion ◽  
Anion Radical ◽  
Superoxide Radical ◽  
Superoxide Anion Radical ◽  
The Other ◽  
Superoxide Radical Anion ◽  
Diffusion Controlled

Even though reaction of the superoxide anion radical/hydroperoxide radical could lead to oxidation of biomolecules, it can reduce oxidized DNA at diffusion controlled rates.

Concerted double proton-transfer electron-transfer between catechol and superoxide radical anion

2017 ◽  
Vol 19 (38) ◽  
pp. 26179-26190 ◽  
Author(s):  
Jorge Quintero-Saumeth ◽  
David A. Rincón ◽  
Markus Doerr ◽  
Martha C. Daza
Keyword(s):  
Electron Transfer ◽  
Proton Transfer ◽  
Superoxide Anion ◽  
Radical Anion ◽  
Reaction Rate ◽  
Superoxide Radical ◽  
Superoxide Radical Anion ◽  
Double Proton Transfer

Catechol reacts with a superoxide anion via concerted double proton-transfer electron-transfer with a reaction rate that is dominated by tunneling.

Intermolecular interactions and proton transfer in the hydrogen halide–superoxide anion complexes

2016 ◽  
Vol 18 (8) ◽  
pp. 6201-6208 ◽  
Author(s):  
Sebastian J. R. Lee ◽  
J. Wayne Mullinax ◽  
Henry F. Schaefer
Keyword(s):  
Proton Transfer ◽  
Ab Initio ◽  
Intermolecular Interactions ◽  
Superoxide Anion ◽  
Radical Anion ◽  
Superoxide Radical ◽  
Hydrogen Halide ◽  
Superoxide Radical Anion ◽  
Anion Complexes

We characterize the intermolecular interactions between the halogen halides and the superoxide radical anion with ab initio computations.

Changes in the superoxide radical and superoxide dismutase levels in the uterus of Rattus norvegicus during the estrous cycle and a possible role for superoxide radical in uterine oedema and cell proliferation at proestrus

1991 ◽  
Vol 69 (4) ◽  
pp. 313-316 ◽  
Author(s):  
M. Laloraya ◽  
G. P. Kumar ◽  
M. M. Laloraya
Keyword(s):  
Cell Proliferation ◽  
Superoxide Dismutase ◽  
Superoxide Anion ◽  
Anion Radical ◽  
Superoxide Radical ◽  
Inverse Correlation ◽  
Oestrous Cycle ◽  
Superoxide Anion Radical ◽  
Albino Rat ◽  
Cyclic Changes

Superoxide anion radical, a radical whose toxicity is well documented, is present in the uterus of albino rat. The cyclic changes that it undergoes during the reproductive cycle are also illustrated. An inverse correlation is seen between the levels of superoxide radical and the enzyme dismutating it, i.e., superoxide dismutase (EC 1.15.1.1), which is also reported to be present in the uterus of albino rat and is shown to exhibit cyclic changes during its oestrous cycle. The high levels of superoxide radical at pro-oestrus enable us to hypothesize that superoxide may be involved in regulating the oedema and cell proliferation of the uterus during proestrus.Key words: superoxide anion radical, superoxide dismutase, uterus, oestrous cycle, uterine oedema, cell proliferation.

Superoxide Anion Radical: Generation and Detection in Cellular and Non-Cellular Systems

2015 ◽  
Vol 22 (37) ◽  
pp. 4234-4256 ◽  
Author(s):  
Renan Chiste ◽  
Marisa Freitas ◽  
Adriana Mercadante ◽  
Eduarda Fernandes
Keyword(s):  
Superoxide Anion ◽  
Anion Radical ◽  
Cellular Systems ◽  
Superoxide Anion Radical ◽  
Radical Generation

The pulse radiolytic study of one-electron oxidation of hydropropidine and hydroethidine – implications for the detection of superoxide radical anion in biological systems

2018 ◽  
Vol 120 ◽  
pp. S157 ◽  
Author(s):  
Radoslaw Michalski ◽  
Bartosz Michalowski ◽  
Jakub Pieta ◽  
Jacek Zielonka ◽  
Balaraman Kalyanaraman ◽  
...  
Keyword(s):  
Radical Anion ◽  
Superoxide Radical ◽  
Biological Systems ◽  
Superoxide Radical Anion
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