The intriguing chemistry and biology of soraphens

2019 ◽  
Vol 36 (10) ◽  
pp. 1394-1411 ◽  
Author(s):  
Arun Naini ◽  
Florenz Sasse ◽  
Mark Brönstrup
Keyword(s):  
Biological Effects ◽  
Acetyl Coa Carboxylase ◽  
Sorangium Cellulosum ◽  
Acetyl Coa ◽  
Potent Inhibition

Soraphens, discovered from the myxobacterial strain Sorangium cellulosum, have intrigued chemists and biologists due to their diverse biological effects mediated by the potent inhibition of acetyl CoA carboxylase.

Abstract 1048: Modulation of lipid metabolism through inhibition of acetyl-CoA carboxylase with ND-646 leads to potent inhibition of breast cancer cell growthin vitroandin vivo

2016 ◽  
Author(s):  
Jennifer L. Rocnik ◽  
Wenyan Miao ◽  
Geraldine Harriman ◽  
Jeremy Greenwood ◽  
Sathesh Bhat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Metabolism ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Potent Inhibition

The role of rice bran extract on acetyl CoA carboxylase in liver of rats fed a high-fat diet

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Charkhonpunya ◽  
S Sireeratawong ◽  
S Komindr ◽  
N Lerdvuthisopon
Keyword(s):  
Rice Bran ◽  
High Fat Diet ◽  
Acetyl Coa Carboxylase ◽  
High Fat ◽  
Acetyl Coa ◽  
Rice Bran Extract

Acetyl‐CoA carboxylase‐1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO

2021 ◽  
Author(s):  
Thuy Nguyen‐Phuong ◽  
Hyunwoo Chung ◽  
Jiyun Jang ◽  
Jung‐Sik Kim ◽  
Chung‐Gyu Park
Keyword(s):  
Dendritic Cells ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa

scholarly journals Polymer-protomer transition of acetyl-CoA carboxylase occurs in vivo and varies with nutritional conditions.

1980 ◽  
Vol 255 (21) ◽  
pp. 10033-10035
Author(s):  
B.A. Ashcraft ◽  
W.S. Fillers ◽  
S.L. Augustine ◽  
S.D. Clarke
Keyword(s):  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Nutritional Conditions

scholarly journals Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell.

1978 ◽  
Vol 253 (10) ◽  
pp. 3381-3383 ◽  
Author(s):  
M.J. Meredith ◽  
M.D. Lane
Keyword(s):  
Liver Cell ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa
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