Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Nanoscale ◽  
2019 ◽  
Vol 11 (31) ◽  
pp. 14937-14951 ◽  
Author(s):  
Tao Huang ◽  
James A. Holden ◽  
Daniel E. Heath ◽  
Neil M. O'Brien-Simpson ◽  
Andrea J. O'Connor
Keyword(s):  
Particle Size ◽  
Antibacterial Activity ◽  
Antibacterial Agent ◽  
Selenium Nanoparticles ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Size Dependent ◽  
Highly Effective

Selenium nanoparticles (Se NPs) are a promising antibacterial agent to address the challenge of antibiotic resistant bacteria. In this work, the antibacterial activity of the spherical Se NPs was shown to be strongly size dependent.

scholarly journals A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

2020 ◽  
Vol 11 (22) ◽  
pp. 5735-5739 ◽  
Author(s):  
Eunhye Lee ◽  
Xingshu Li ◽  
Juwon Oh ◽  
Nahyun Kwon ◽  
Gyoungmi Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antibacterial Activity ◽  
Boronic Acid ◽  
Reactive Oxygen ◽  
Resistant Bacteria ◽  
Ros Generation ◽  
Oxygen Species ◽  
Photodynamic Effect ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

A boronic acid functionalized phthalocyanine displays aggregation-enhanced reactive oxygen species (ROS) generation and excellent photodynamic antibacterial activity.

scholarly journals Antibacterial Activity of Volatile Organic Compounds Produced by the Octocoral-Associated Bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 923
Author(s):  
Anette Garrido ◽  
Librada A. Atencio ◽  
Rita Bethancourt ◽  
Ariadna Bethancourt ◽  
Héctor Guzmán ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Solid Phase ◽  
Resistant Bacteria ◽  
Bacillus Sp ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Associated Bacteria ◽  
Volatile Organic

The present research aimed to evaluate the antibacterial activity of volatile organic compounds (VOCs) produced by octocoral-associated bacteria Bacillus sp. BO53 and Pseudoalteromonas sp. GA327. The volatilome bioactivity of both bacteria species was evaluated against human pathogenic antibiotic-resistant bacteria, methicillin-resistant Staphylococcus aureus, Acinetobacter baumanni, and Pseudomonas aeruginosa. In this regard, the in vitro tests showed that Bacillus sp. BO53 VOCs inhibited the growth of P. aeruginosa and reduced the growth of S. aureus and A. baumanni. Furthermore, Pseudoalteromonas sp. GA327 strongly inhibited the growth of A. baumanni, and P. aeruginosa. VOCs were analyzed by headspace solid-phase microextraction (HS-SPME) joined to gas chromatography-mass spectrometry (GC-MS) methodology. Nineteen VOCs were identified, where 5-acetyl-2-methylpyridine, 2-butanone, and 2-nonanone were the major compounds identified on Bacillus sp. BO53 VOCs; while 1-pentanol, 2-butanone, and butyl formate were the primary volatile compounds detected in Pseudoalteromonas sp. GA327. We proposed that the observed bioactivity is mainly due to the efficient inhibitory biochemical mechanisms of alcohols and ketones upon antibiotic-resistant bacteria. This is the first report which describes the antibacterial activity of VOCs emitted by octocoral-associated bacteria.

scholarly journals Antibacterial activity of Cathormion umbellatum

2021 ◽  
Vol 16 (3) ◽  
pp. 91-95
Author(s):  
Surachai Rattanasuk ◽  
Rujirek Boongapim ◽  
Tannatorn Phiwthong
Keyword(s):  
Antibacterial Activity ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Antibacterial Effect ◽  
Colorimetric Assay ◽  
Inhibition Zone ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Diffusion Assay

The aim of this study was to determine the antibacterial activity of Cathormion umbellatum extracts against seven antibiotic-resistant bacteria. The pods, leaves and branches of C. umbellatum were extracted with ethanol and methanol. The disc diffusion assay was used to screen the antibacterial activity and broth microdilution and colorimetric assay were used to measure the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The result indicated that the highest inhibition zone (11 mm) was presented in ethanolic pods extract against multidrug resistance Klebsiella pneumoniae. The lowest MIC value of 0.05 mg/mL was obtained from branch extracted with ethanol against colistin resistant Pseudomonas aeruginosa. The lowest MBC values of 1.56 mg/mL were obtained when using C. umbellatum leaves extracted with methanol against all test antibiotic-resistant bacteria. This is the first report presented C. umbellatum extracts have the potential to eliminate antibiotic-resistant bacteria in patients. These findings show the antibacterial effect of C. umbellatum.

scholarly journals Antibacterial Activity of Green-Synthesized Silver Nanoparticles Using Areca catechu Extract against Antibiotic-Resistant Bacteria

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 205
Author(s):  
Jeong Choi ◽  
Hyon Jung ◽  
Yeon Baek ◽  
Bo Kim ◽  
Min Lee ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Bacterial Species ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Sem Images ◽  
Antibiotic Resistant ◽  
Areca Catechu ◽  
Ft Ir ◽  
Green Synthesized Silver Nanoparticles

In this work, the antibacterial activity of silver nanoparticles (AgNPs) synthesized using Areca catechu extracts against three species of antibiotic-susceptible and three species of resistant bacteria was investigated. The effects of this plant were more promising when compared with other medicinal plants tested. The hydrothermal extract of Areca catechu was mixed with silver nitrate to synthesize AgNPs. The synthesized particle characteristics were analyzed by UV–Vis spectrophotometry, scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FT-IR). Minimum inhibitory concentration and minimum bactericidal concentration tests were conducted to confirm antibacterial activity and the results showed that AgNPs synthesized using Areca catechu extracts effectively inhibited the growth of bacterial species. Moreover, the SEM images of the bacterial species treated with AgNPs synthesized with Areca catechu extracts showed that clusters of AgNPs were attached to the surface of the bacterial cell wall, which could induce destruction of the cell membranes. The results suggest that AgNPs synthesized with Areca catechu extracts have the potential to treat antibiotic-resistant bacteria known as the major cause of nosocomial infections.

Boosting the antibacterial activity of chitosan–gold nanoparticles against antibiotic–resistant bacteria by Punicagranatum L. extract

2021 ◽  
Vol 256 ◽  
pp. 117498
Author(s):  
Mohamed A. Mohamady Hussein ◽  
Mariusz Grinholc ◽  
Ahmed S. Abo Dena ◽  
Ibrahim M. El-Sherbiny ◽  
Mosaad Megahed
Keyword(s):  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant

scholarly journals Discovery of Antibacterial Dietary Spices That Target Antibiotic-Resistant Bacteria

2019 ◽  
Vol 7 (6) ◽  
pp. 157 ◽  
Author(s):  
Dan Zhang ◽  
Ren-You Gan ◽  
Arakkaveettil Kabeer Farha ◽  
Gowoon Kim ◽  
Qiong-Qiong Yang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Effect ◽  
Antioxidant Activities ◽  
Antibacterial Properties ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Dietary Spices

Although spice extracts are well known to exhibit antibacterial properties, there is lack of a comprehensive evaluation of the antibacterial effect of spices against antibiotic-resistant bacteria. In the present study, ethanolic extracts from a total of 67 spices were comprehensively investigated for their in vitro antibacterial activities by agar well diffusion against two common food-borne bacteria, Staphylococcus aureus and Salmonella enteritidis, with multi-drug resistance. Results showed that S. aureus was generally more sensitive to spice extracts than S. enteritidis. Of the 67 spice extracts, 38 exhibited antibacterial activity against drug-resistant S. aureus, while only four samples were effective on drug-resistant S. enteritidis. In addition, 11 spice extracts with inhibition zones greater than 15 mm were further verified for their broad-spectrum antibacterial properties using another 10 drug-resistant S. aureus strains. It was found that five spice extracts, including galangal, fructus galangae, cinnamon, yellow mustard seed, and rosemary, exhibited the highest antibacterial capacity. Further cytotoxicity of these 11 spices was determined and LC50 values were found to be more than 100 μg/mL except for galangal, rosemary, and sage, whose LC50 values were 9.32 ± 0.83, 19.77 ± 2.17, and 50.54 ± 2.57, respectively. Moreover, the antioxidant activities (ferric-reducing antioxidant power (FRAP) and trolox equivalent antioxidant capacity (TEAC) values) and total phenolic content (TPC) of spice extracts were determined to establish possible correlations with the antibacterial activity. Although the antibacterial effect was positively correlated with the antioxidant activities and TPC, the correlation was weak (r < 0.5), indicating that the antibacterial activity could also be attributed to other components besides antioxidant polyphenols in the tested spice extracts. In conclusion, dietary spices are good natural sources of antibacterial agents to fight against antibiotic-resistant bacteria, with potential applications as natural food preservatives and natural alternatives to antibiotics in animal feeding.

scholarly journals Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria

2000 ◽  
Vol 31 (4) ◽  
Author(s):  
Gislene G. F. Nascimento ◽  
Juliana Locatelli ◽  
Paulo C. Freitas ◽  
Giuliana L. Silva
Keyword(s):  
Antibacterial Activity ◽  
Plant Extracts ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant
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