The synergistic effect of Au-COF nanosheets and artificial peroxidase Au@ZIF-8(NiPd) rhombic dodecahedra for signal amplification for biomarker detection

With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

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Sensitive mutant DNA biomarker detection based on magnetic nanoparticles and nicking endonuclease assisted fluorescence signal amplification

RSC Advances ◽

10.1039/c4ra17059h ◽

2015 ◽

Vol 5 (26) ◽

pp. 20020-20024 ◽

Cited By ~ 8

Author(s):

Na Li ◽

Zhong Feng Gao ◽

Bei Hua Kang ◽

Nian Bing Li ◽

Hong Qun Luo

Keyword(s):

Magnetic Nanoparticles ◽

Signal Amplification ◽

Fluorescence Signal ◽

Biomarker Detection ◽

Background Signal ◽

Sensitive Mutant ◽

Nicking Endonuclease ◽

Low Background ◽

Target Dna ◽

Fluorescence Signal Amplification

Amplified fluorescence target DNA detection was developed combining nicking endonuclease assisted target recycling and magnetic nanoparticles with low background signal.

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Ultrasensitive sandwich-type electrochemical immunosensor based on a novel signal amplification strategy using highly loaded palladium nanoparticles/carbon decorated magnetic microspheres as signal labels

Biosensors and Bioelectronics ◽

10.1016/j.bios.2015.02.010 ◽

2015 ◽

Vol 68 ◽

pp. 757-762 ◽

Cited By ~ 26

Author(s):

Lei Ji ◽

Zhankui Guo ◽

Tao Yan ◽

Hongmin Ma ◽

Bin Du ◽

...

Keyword(s):

Signal Amplification ◽

Palladium Nanoparticles ◽

Electrochemical Immunosensor ◽

Magnetic Microspheres ◽

Sandwich Type ◽

Amplification Strategy ◽

Highly Loaded

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rhEPO/EPO discrimination with ultrasensitive electrochemical biosensor based on sandwich-type nano-Au/ZnO sol–gel/nano-Au signal amplification

Biosensors and Bioelectronics ◽

10.1016/j.bios.2013.06.038 ◽

2013 ◽

Vol 50 ◽

pp. 217-223 ◽

Cited By ~ 14

Author(s):

Liqun Zhang ◽

Yunxia Wang ◽

Jingjing Wang ◽

Jianfeng Shi ◽

Kun Deng ◽

...

Keyword(s):

Signal Amplification ◽

Electrochemical Biosensor ◽

Sol Gel ◽

Sandwich Type

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A portable multi-signal readout sensing platform based on plasmonic MXene induced signal amplification for point of care biomarker detection

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2021.131059 ◽

2021 ◽

pp. 131059

Author(s):

Yanjie Chen ◽

Jie Wei ◽

Shupei Zhang ◽

Hong Dai ◽

Jianying Yan ◽

...

Keyword(s):

Signal Amplification ◽

Point Of Care ◽

Biomarker Detection ◽

Sensing Platform ◽

Induced Signal ◽

Signal Readout

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Synergistic effect of sandwich polyoxometalates and copper–imidazole complexes for enhancing the peroxidase-like activity

RSC Advances ◽

10.1039/c5ra13265g ◽

2015 ◽

Vol 5 (96) ◽

pp. 78771-78779 ◽

Cited By ~ 23

Author(s):

Dong-Feng Chai ◽

Zhuo Ma ◽

Hong Yan ◽

YunFeng Qiu ◽

Hong Liu ◽

...

Keyword(s):

Synergistic Effect ◽

Sandwich Polyoxometalates ◽

Imidazole Complexes ◽

Sandwich Type

Two inorganic–organic hybrids based on copper(ii)–imidazole complex modified sandwich-type tungstobismuthate or tungstoantimonite, have been synthesized, demonstrating higher peroxidase-like activity using TMB as a peroxidase substrate.

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