A Fluorogenic RNA Aptamers Nanodevice for Low Background Imaging of mRNA in Living Cells

A fluorogenic RNA aptamers nanodevice integrating the entropy-driven RNA amplifier with near-infrared (NIR) light controller, affording high contrast and sensitivity for imaging the low-abundance mRNA in living cells. The design...

Production and validation of scintillating structural components from low-background Poly(ethylene naphthalate)

Poly Ethylene Naphthalate (PEN) is an industrial polymer plastic which is investigated as a low background, transparent, scintillating and wavelength shifting structural material. PEN scintillates in the blue region and has excellent mechanical properties both at room and cryogenic temperatures. Thus, it is an ideal candidate for active structural components in experiments for the search of rare events like neutrinoless double-beta decay or dark matter recoils. Such optically active structures improve the identification and rejection efficiency of backgrounds events, like this improving the sensitivity of experiments. This paper reports on the production of radiopure and transparent PEN plates These structures can be used to mount germanium detectors operating in cryogenic liquids (LAr, LN). Thus, as first application PEN holders will be used to mount the Ge detectors in the Legend-200 experiment. The whole process from cleaning the raw material to testing the PEN active components under final operational conditions is reported.

Evaluation of Gross Alpha and Beta Activity Concentrations and Annual Effective Dose in Drinking Waters of Misan Province-Iraq Using Low Background Gas Flow Proportional Counter (LB- 4110)

In this study, assessment of levels natural radioactivity in drinking water samples of Misan Province of Iraq was carried out. A total of 33 (Tigris river, station and Tap) water samples collected from eleven places in Misan Province of Iraq. The beta and alpha gross radioactivity of the samples water was measured and an average annual effective dose derived of drinking-water ingestion was estimation utilizing new model a LB-4110 low background gas flow proportional counter. The data indicated that the Beta and Alpha gross activities and annual effective dose in samples did not exceed WHO recommended levels (0.5 Bq/L of Alpha gross, 1.0 Bq/L of Beta gross and 0.1 mSv/y for annual effective dose).

A Comparison of Muon Flux Models at Sea Level for Muon Imaging and Low Background Experiments

Cosmic-ray muons are a type of natural radiation with high energy and a strong penetration ability. The flux distribution of such particles at sea level is a key problem in many areas, especially in the field of muon imaging and low background experiments. This paper summarizes the existing models to describe sea-level muon flux distributions. According to different means used, four parametric analytical models and one Monte Carlo model, which is referred to as CRY, are selected as typical sea-level muon flux distribution models. Then, the theoretical values of sea-level muon fluxes given by these models are compared with the experimental sea-level muon differential flux data with kinetic energy values in the range of 1–1,000 GeV in the directions of zenith angles 0° and 75°. The goodness of fit of these models to the experimental data was quantitatively calculated by Pearson’s chi-square test. The results of the comparison show that the commonly used Gaisser model overestimates the muon flux in the low-energy region, while the muon flux given by the Monte Carlo model CRY at the large zenith angle of 75° is significantly lower than that of the experimental data. The muon flux distribution given by the other three parametric analytical models is consistent with the experimental data. The results indicate that the original Gaisser model is invalid in the low energy range, and CRY apparently deviates at large zenith angles. These two models can be substituted with the muon flux models given by Gaisser/Tang, Bugaev/Reyna, and Smith and Duller/Chatzidakis according to actual experimental conditions.

Multi-track displaced vertices at B-factories

We propose a program at B-factories of inclusive, multi-track displaced vertex searches, which are expected to be low background and give excellent sensitivity to non-minimal hidden sectors. Multi-particle hidden sectors often include long-lived particles (LLPs) which result from approximate symmetries, and we classify the possible decays of GeV-scale LLPs in an effective field theory framework. Considering several LLP production modes, including dark photons and dark Higgs bosons, we study the sensitivity of LLP searches with different number of displaced vertices per event and track requirements per displaced vertex, showing that inclusive searches can have sensitivity to a large range of hidden sector models that are otherwise unconstrained by current or planned searches.

Imaging of glial tumor recurrence using [68Ga]Ga-PSMA-11 PET/CT

Background and PurposeLimited data is available on the possible use of [68Ga]Ga-PSMA-11 PET/CT for the diagnosis of glioma recurrence. The aim of this paper was to assess the use of [68Ga]Ga-PSMA-11 PET/CT for the detection of recurrence in different glial tumors.Materials and Methods34 patients (pts.) aged 44.5±10.3 years with suspicion of recurrence of histologically confirmed glioma grade III (6 pts.) and grade IV (28 pts.) were included in the study. All patients underwent contrast-enhanced MR and [68Ga]Ga-PSMA-11 PET/CT.ResultsNo radiopharmaceutical-related adverse events were noted. PET/CT was positive in all the areas suspected for recurrence at MR in all the patients. The recurrence was confirmed by histopathological examinations or follow-up imaging in all cases. The images showed a very low background activity of the normal brain. Median maximal standard uptake value (SUVmax) of the tumors was 6.5 (range: 0.9–15.6) and mean standard uptake value (SUVmean) was 3.5 (range: 0.9–7.5). Target-to-background (TBR) ratios varied between 15 and 1400 with a median of 152. Target-to-liver background ratios (TLR) ranged from 0.2 to 2.6, the median TLR was 1.3. No significant difference of the measured parameters was found between the subgroups according to the glioma grade.Conclusion[68Ga]Ga-PSMA-11 PET/CT shows excellent results in the diagnosis of glioma recurrence of various grades. Due to the very low background activity, this method provides high-quality images and allows for the detection of well-defined recurrence lesions.