scholarly journals Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

2020 ◽  
Vol 19 (5) ◽  
pp. 674-680
Author(s):  
Sébastien Jenni ◽  
Giacomo Picci ◽  
Marco Fornasier ◽  
Marianna Mamusa ◽  
Judith Schmidt ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Cancer Therapy ◽  
Liquid Crystalline ◽  
Antineoplastic Drug ◽  
Pluronic F108 ◽  
Liquid Crystalline Nanoparticles ◽  
Potential Cancer

Multifunctional lipidic cubic liquid crystalline nanoparticles for potential cancer therapy were engineered by conjugating a porphyrin-based photosensitizer to the block copolymer Pluronic F108 and loading them with the antineoplastic drug Docetaxel.

Synthesis of azobenzene-containing liquid crystalline block copolymer nanoparticles via polymerization induced hierarchical self-assembly

2021 ◽  
Author(s):  
Wei Wen ◽  
Wangqi Ouyang ◽  
Song Guan ◽  
Aihua Chen
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Facile Synthesis ◽  
Liquid Crystalline Nanoparticles

A facile synthesis of non-spherical photoresponsive azobenzene-containing liquid crystalline nanoparticles via polymerization-induced hierarchical self-assembly (PIHSA).

scholarly journals Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1400 ◽  
Author(s):  
Maria Chountoulesi ◽  
Natassa Pippa ◽  
Varvara Chrysostomou ◽  
Stergios Pispas ◽  
Evangelia D. Chrysina ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Liquid Crystalline ◽  
Polymer Concentration ◽  
Morphological Characteristics ◽  
Amphiphilic Block Copolymer ◽  
Poloxamer 407 ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Liquid Crystalline Nanoparticles

There is an emerging need to evolve the conventional lyotropic liquid crystalline nanoparticles to advanced stimuli-responsive, therapeutic nanosystems with upgraded functionality. Towards this effort, typically used stabilizers, such as Pluronics®, can be combined or replaced by smart, stimuli-responsive block copolymers. The aim of this study is to incorporate the stimuli-responsive amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as a stabilizer in lipidic liquid crystalline nanoparticles, in order to provide steric stabilization and simultaneous stimuli-responsiveness. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by light scattering techniques, cryogenic-transmission electron microscopy (cryo-TEM), X-ray diffraction (XRD) and fluorescence spectroscopy. The PDMAEMA-b-PLMA, either individually or combined with Poloxamer 407, exhibited different modes of stabilization depending on the lipid used. Due to the protonation ability of PDMAEMA blocks in acidic pH, the nanoparticles exhibited high positive charge, as well as pH-responsive charge conversion, which can be exploited towards pharmaceutical applications. The ionic strength, temperature and serum proteins influenced the physicochemical behavior of the nanoparticles, while the polymer concentration differentiated their morphology; their micropolarity and microfluidity were also evaluated. The proposed liquid crystalline nanosystems can be considered as novel and attractive pH-responsive drug and gene delivery nanocarriers due to their polycationic content.

scholarly journals Quality by design (QbD) in the formulation and optimization of liquid crystalline nanoparticles (LCNPs): A risk based industrial approach

2021 ◽  
Vol 141 ◽  
pp. 111940
Author(s):  
Tejashree Waghule ◽  
Neha Dabholkar ◽  
Srividya Gorantla ◽  
Vamshi Krishna Rapalli ◽  
Ranendra Narayan Saha ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Quality By Design ◽  
Liquid Crystalline Nanoparticles

Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

Life Sciences ◽  
2021 ◽  
Vol 276 ◽  
pp. 119436
Author(s):  
Keshav Raj Paudel ◽  
Ridhima Wadhwa ◽  
Xin Nee Tew ◽  
Natalie Jia Xin Lau ◽  
Thiagarajan Madheswaran ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Liquid Crystalline ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cancer Proliferation ◽  
Liquid Crystalline Nanoparticles ◽  
And Migration ◽  
Proliferation And Migration

Microenvironment pH-Induced Selective Cell Death for Potential Cancer Therapy Using Nanofibrous Self-Assembly of a Peptide Amphiphile

2021 ◽  
Author(s):  
Shota Yamamoto ◽  
Kanon Nishimura ◽  
Kenta Morita ◽  
Sayuki Kanemitsu ◽  
Yuki Nishida ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Self Assembly ◽  
Peptide Amphiphile ◽  
Potential Cancer ◽  
Microenvironment Ph

Double Ordered Layers within Microphase-separated Lamellar Structure of Double Liquid Crystalline Side-chain Type Block Copolymer

2008 ◽  
Vol 37 (11) ◽  
pp. 1174-1175 ◽  
Author(s):  
Rina Maeda ◽  
Teruaki Hayakawa ◽  
Masatoshi Tokita ◽  
Masa-aki Kakimoto ◽  
Hiroaki Urushibata
Keyword(s):  
Block Copolymer ◽  
Lamellar Structure ◽  
Liquid Crystalline ◽  
Side Chain ◽  
Chain Type ◽  
Ordered Layers

Understanding the kinetic mixing between liquid crystalline nanoparticles and agrochemical actives

2019 ◽  
Vol 175 ◽  
pp. 324-332
Author(s):  
Nicole B. Bisset ◽  
Graham R. Webster ◽  
Yao Da. Dong ◽  
Ben J. Boyd
Keyword(s):  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles

“Liquid Crystalline Nanoparticles”: Rationally Designed Vehicle To Improve Stability and Therapeutic Efficacy of Insulin Following Oral Administration

2017 ◽  
Vol 14 (6) ◽  
pp. 1874-1882 ◽  
Author(s):  
Ashish Kumar Agrawal ◽  
Kuldeep Kumar ◽  
Nitin Kumar Swarnakar ◽  
Varun Kushwah ◽  
Sanyog Jain
Keyword(s):  
Oral Administration ◽  
Therapeutic Efficacy ◽  
Liquid Crystalline ◽  
Liquid Crystalline Nanoparticles ◽  
Improve Stability
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