Diblock brush-arm star copolymers via a core-first/graft-from approach using γ-cyclodextrin and ROMP: a modular platform for drug delivery

2020 ◽  
Vol 11 (2) ◽  
pp. 541-550 ◽  
Author(s):  
Ruihan Li ◽  
Xuesong Li ◽  
Yipei Zhang ◽  
Abigail O. Delawder ◽  
Nathan D. Colley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Ring Opening ◽  
Water Soluble ◽  
Ring Opening Metathesis Polymerization ◽  
Metathesis Polymerization ◽  
Anticancer Drug Delivery ◽  
Star Copolymers ◽  
Modular Platform

Water-soluble diblock brush-arm star copolymers using γ-CD-based core-first ring-opening metathesis polymerization, allowing for anticancer drug delivery via host–guest interaction.

scholarly journals Dewar Heterocycles as Versatile Monomers for Ring-Opening Metathesis Polymerization

2020 ◽  
Author(s):  
Sepand Nistanaki ◽  
Hosea Nelson
Keyword(s):  
Ring Opening ◽  
Water Soluble ◽  
Ring Opening Metathesis Polymerization ◽  
Valence Isomerization ◽  
Metathesis Polymerization ◽  
Grubbs Catalysts ◽  
Amino Acid Polymers ◽  
Highly Strained ◽  
Acetylene Derivatives ◽  
Soluble Poly

We report the utility of readily available heterocycles as precursors to unique ring-opening metathesis polymerization (ROMP) monomers. Photochemical valence isomerization reactions of pyridones, dihydropyridines, and pyrones dearomatize the parent heterocycles to their highly strained Dewar isomers, which readily engage in controlled ROMP reactions using Grubbs catalysts. This strategy is used to access novel polymer backbones that contain strained β-lactam and azetidine cores, which can be further derivatized using post-polymerization chemistries. We demonstrate this through the synthesis of water-soluble β-amino acid polymers and soluble poly(acetylene) derivatives.

Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

2019 ◽  
Vol 55 (73) ◽  
pp. 10892-10895 ◽  
Author(s):  
Guangping Sun ◽  
Zhimei He ◽  
Min Hao ◽  
Zuqiang Xu ◽  
Xiao-Yu Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cancer Diagnosis ◽  
Water Soluble ◽  
Tumor Diagnosis ◽  
Anticancer Drug Delivery ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy

Bifunctional supramolecular prodrug nanocarriers have been successfully constructed for efficient anticancer drug delivery and tumor diagnosis and therapy.

Methoxy polyethylene glycol–cholesterol modified soy lecithin liposomes for poorly water‐soluble anticancer drug delivery

2020 ◽  
Vol 138 (7) ◽  
pp. 49858
Author(s):  
Ngoc Thuy Trang Le ◽  
Dinh Tien Dung Nguyen ◽  
Ngoc Hoi Nguyen ◽  
Cuu Khoa Nguyen ◽  
Dai Hai Nguyen
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Anticancer Drug ◽  
Water Soluble ◽  
Soy Lecithin ◽  
Anticancer Drug Delivery ◽  
Poorly Water Soluble ◽  
Methoxy Polyethylene Glycol

Assembly of Catechol-Modified Polymer Brushes for Drug Delivery

2021 ◽  
Author(s):  
Kaijie Zhao ◽  
Zhiliang Gao ◽  
Dongpo Song ◽  
Peiyu Zhang ◽  
Jiwei Cui
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Polymer Brushes ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Ring Opening Metathesis Polymerization ◽  
Metathesis Polymerization ◽  
Modified Polymer

Therapeutic nanoparticles (NPs) have shown their potential for biomedical applications (e.g., drug delivery). In this study, we report the synthesis of a bottlebrush block copolymer by ring opening metathesis polymerization...

Optimization of Amphiphilic Miktoarm Star Copolymers for Anticancer Drug Delivery

2018 ◽  
Vol 4 (8) ◽  
pp. 2903-2910 ◽  
Author(s):  
Mingqi Wang ◽  
Xiaolong Zhang ◽  
Han Peng ◽  
Mingkui Zhang ◽  
Xianshuo Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Star Copolymers ◽  
Miktoarm Star

Aggregation-induced emission block copolymers based on ring-opening metathesis polymerization

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51194-51200 ◽  
Author(s):  
Yuming Zhao ◽  
Ying Wu ◽  
Guowei Yan ◽  
Ke Zhang
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Ring Opening ◽  
Water Soluble ◽  
Amphiphilic Block Copolymers ◽  
Ring Opening Metathesis Polymerization ◽  
Metathesis Polymerization ◽  
Aggregation Induced Emission ◽  
Selective Solvents ◽  
First Time

AIE amphiphilic block copolymers were developed from ROMP for the first time. By self-assembly in selective solvents, water soluble fluorescent nano-objects were prepared with varied structures including micelles and vesicles.

scholarly journals Dewar Heterocycles as Versatile Monomers for Ring-Opening Metathesis Polymerization

2020 ◽  
Author(s):  
Sepand Nistanaki ◽  
Hosea Nelson
Keyword(s):  
Ring Opening ◽  
Water Soluble ◽  
Ring Opening Metathesis Polymerization ◽  
Valence Isomerization ◽  
Metathesis Polymerization ◽  
Grubbs Catalysts ◽  
Amino Acid Polymers ◽  
Highly Strained ◽  
Acetylene Derivatives ◽  
Soluble Poly

We report the utility of readily available heterocycles as precursors to unique ring-opening metathesis polymerization (ROMP) monomers. Photochemical valence isomerization reactions of pyridones, dihydropyridines, and pyrones dearomatize the parent heterocycles to their highly strained Dewar isomers, which readily engage in controlled ROMP reactions using Grubbs catalysts. This strategy is used to access novel polymer backbones that contain strained β-lactam and azetidine cores, which can be further derivatized using post-polymerization chemistries. We demonstrate this through the synthesis of water-soluble β-amino acid polymers and soluble poly(acetylene) derivatives.

Multifunctional carbon nanomateriels for camptothecine low-water soluble anticancer drug delivery

2018 ◽  
Vol 42 (2) ◽  
pp. 1326-1336 ◽  
Author(s):  
Asma Itatahine ◽  
Yamina Ait Mehdi ◽  
Meriem Fizir ◽  
Man Qi ◽  
Pierre Dramou ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Water Soluble ◽  
Magnetic Graphene Oxide ◽  
Hybrid Nanomaterial ◽  
Anticancer Drug Delivery ◽  
Magnetic Carbon ◽  
Magnetic Carbon Nanotubes

A multifunctional hybrid nanomaterial of magnetic graphene oxide (GO) and magnetic carbon nanotubes (CNTs) was ensheathed with mesoporous silica, for the loading and delivery of an anticancer drug, camptothecine (CPT).

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