scholarly journals A green approach to obtain stable and hydrophilic cellulose-based electrospun nanofibrous substrates for sustained release of therapeutic molecules

RSC Advances ◽  
2019 ◽  
Vol 9 (37) ◽  
pp. 21288-21301 ◽  
Author(s):  
Manja Kurečič ◽  
Tamilselvan Mohan ◽  
Natalija Virant ◽  
Uroš Maver ◽  
Janja Stergar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sustained Release ◽  
Tissue Regeneration ◽  
Green Approach ◽  
Therapeutic Molecules ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Stable and (bio)-compatible nanofibrous matrices showing effective incorporation and release of nonsteroidal anti-inflammatory drugs (NSAIDs) hold a huge potential in tissue regeneration and wound healing.

scholarly journals Time related effects of non-steroidal anti-inflammatory drugs on Achilles tendinopathy in a murine model

2017 ◽  
Vol 2 (2) ◽  
pp. 2473011416S0000 ◽  
Author(s):  
Adam Bitterman ◽  
Shuguang Gao ◽  
Katie Trella ◽  
Jun Li ◽  
Jorge Galante ◽  
...  
Keyword(s):  
Wound Healing ◽  
Murine Model ◽  
Achilles Tendinopathy ◽  
Early Postoperative Period ◽  
Post Injury ◽  
Thin Sections ◽  
Delayed Treatment ◽  
Systemic Mechanism ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Category: Basic Sciences/Biologics Introduction/Purpose: Tendinopathy has been identified to result from work and sports-related activities, in many patients. Common treatment for such degenerative tendon pathology includes non-steroidal anti-inflammatory drugs (NSAIDs). Although they provide pain relief, their mechanistic effects, on modulating inflammation associated with tendinopathy is poorly understood. Recent reports suggest impaired functional healing of rat rotator cuff tear repairs when treated in the early postoperative period with ibuprofen, while delayed treatment did not affect healing. We have now identified, using a murine model, a cascade of genes associated with innate inflammation, which influence premature fibrotic scarring without repair. The objective of this study was to evaluate the effects of orally administered ibuprofen on inflammation and wound-healing responses after initiation and during progression of Achilles tendinopathy in a murine model. Methods: All animal experimentation was carried out under IACUC approval. C57BL/6 wild-type male mice (12 wks) received two injections, two days apart, of 100ng rhTGF-β1 into the midportion of the Achilles tendon. Ibuprofen (IBU) was administered orally as described by Ezell et al5, for 7 days either 1 day (Early) or 8 days (Late) after the initiating injury. Experimental groups were 1) Tendinopathy + NO drug, 2) Tendinopathy + IBU Early, 3) Tendinopathy + IBU Late, 4) Naïve mice + IBU Early. Following sacrifice of the mice at 28 days post injury, Achilles tendons were harvested, and RNA was prepared as described by Trella et al6, for transcriptomic analyses using wound healing and NfKb target gene platforms (PAMM-121A, PAMM-225ZA Qiagen, Valencia, CA). Tendon histopathology was assessed on paraffin embedded thin sections using standard methods for HE and Safranin O staining. Results: Both early and late dosing times with ibuprofen prolonged the innate inflammation response genes (e.g., PGE Synthase, Interleukin1b, Interferon gamma, Cxcl3 chemokine), relative to untreated tendinopathy. Furthermore, early dosing also elevated collagen genes (Collagens 1, 3 and 5), and such a response has been associated with fibrotic scarring. Drug administration to naïve mice showed no significant effects on gene expression in the tendons. Conclusion: This study represents the first report of the time related effect of ibuprofen on mechanisms involved in healing of tendinopathy. If the drug is administered early after the initiating injury, a prolonged increase in inflammation and potential for scarring in the tendon was observed, whereas later administration resulted in persistent inflammation only. The data suggest that the anti-inflammatory action of such NSAID may occur outside of the tendon (such as the bone marrow) resulting in a dysregulated systemic mechanism that controls the innate (tendon) inflammation and healing pathways.

Thermo-sensitive poly(VCL-4VP-NVP) ionic microgels: synthesis, cytotoxicity, hemocompatibility, and sustained release of anti-inflammatory drugs

2017 ◽  
Vol 1 (2) ◽  
pp. 369-379 ◽  
Author(s):  
Xianjing Zhou ◽  
Qing Yang ◽  
Jianyuan Li ◽  
Jingjing Nie ◽  
Guping Tang ◽  
...  
Keyword(s):  
Sustained Release ◽  
Diclofenac Sodium ◽  
Good Biocompatibility ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Thermosensitive poly(VCL-4VP-NVP) ionic microgels showed good biocompatibility, excellent hemocompatibility and were suitable for the loading and sustained release of diclofenac sodium.

Effects of Steroid and Nonsteroidal Anti-inflammatory Drugs on Acute Wound Healing and Collagen Synthesis in Rat Skin

2003 ◽  
Vol 38 (4) ◽  
pp. 393 ◽  
Author(s):  
Chang Dong Han ◽  
Whan Mo Lee ◽  
Hun Bum Lee ◽  
Myung Hoon Hahn ◽  
Whan Wook Yu
Keyword(s):  
Wound Healing ◽  
Collagen Synthesis ◽  
Rat Skin ◽  
Acute Wound ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Effect of topical anti-inflammatory drugs on corneal and limbal wound healing

2000 ◽  
Vol 26 (6) ◽  
pp. 893-897 ◽  
Author(s):  
Ken R. Barba ◽  
Arun Samy ◽  
Catherine Lai ◽  
Jay I. Perlman ◽  
Charles S. Bouchard
Keyword(s):  
Wound Healing ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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