Immobilization ofl-methioninase on a zirconium-based metal–organic framework as an anticancer agent

2019 ◽  
Vol 7 (20) ◽  
pp. 3268-3278 ◽  
Author(s):  
Amany A. Hassabo ◽  
Amria M. Mousa ◽  
Hassan Abdel-Gawad ◽  
Mohsen H. Selim ◽  
Reda M. Abdelhameed
Keyword(s):  
Tumor Growth ◽  
Anticancer Agent ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
And Storage ◽  
Organic Framework

A new composite (METase@UiO-66) was prepared froml-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared tol-methioninase. Moreover,in vivoexperiments showed that the drug inhibited tumor growth in mice.

Process of metal−organic framework (MOF)/covalent−organic framework (COF) hybrids-based derivatives and their applications on energy transfer and storage

Nanoscale ◽  
2022 ◽  
Author(s):  
Bingbing Cui ◽  
Guo-Dong Fu
Keyword(s):  
Renewable Energy ◽  
Energy Transfer ◽  
Fossil Fuel ◽  
Metal Organic Framework ◽  
Renewable Energy Sources ◽  
Environmental Issues ◽  
Energy Sources ◽  
Metal Organic ◽  
And Storage ◽  
Organic Framework

The fossil-fuel shortage and severe environmental issues have posed ever-increasing demands on clean and renewable energy sources, for which the exploration of electrocatalysts has been in a big challenge toward...

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Multi-modal channel cancer chemotherapy by 2D functional gadolinium metal-organic framework

2020 ◽  
Author(s):  
Jiale Xia ◽  
Yumeng Xue ◽  
Bo Lei ◽  
Lingling Xu ◽  
Mingzi Sun ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Tumor Tissue ◽  
Tumor Imaging ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
High Surface ◽  
Superior Performance ◽  
Metal Organic ◽  
Organic Framework

Abstract Two-dimensional (2D) nanomaterials generally exhibit enhanced physiochemical and biological functions in biomedical applications due to their high surface-to-volume ratio and surface charge. Conventional cancer chemotherapy based on nanomaterials has been hindered by their low drug loading and poor penetration in tumor tissue. To overcome these difficulties, the novel materials systems are urgently needed. Hereby, the lanthanide-based porphyrin metal organic framework (MOF) nanosheets with promising cancer imaging/chemotherapy capacities are fabricated, which displays superior performance in the drug loading and tumor tissue penetration. The biodegradable PPF-Gd nanosheets deliver an ultrahigh drug loading (>1500%) and demonstrate the stable and highly sensitive stimuli-responsive degradation/release for multimodal tumor imaging and cancer chemotherapy. Meanwhile, PPF-Gd NSs also exhibits excellent fluorescence and magnetic resonance imaging capability in vitro and in vivo. Compared to the traditional DOX chemotherapy, the in vivo results confirm the evident suppression of the tumor growth by the PPF-Gd/DOX drug delivery system with negligible side effects. This work further supports the potential of lanthanide-based MOF nanomaterials as biodegradable systems to promote the cancer theranostics technology development in the future.

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