In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

Immobilization ofl-methioninase on a zirconium-based metal–organic framework as an anticancer agent

2019 ◽  
Vol 7 (20) ◽  
pp. 3268-3278 ◽  
Author(s):  
Amany A. Hassabo ◽  
Amria M. Mousa ◽  
Hassan Abdel-Gawad ◽  
Mohsen H. Selim ◽  
Reda M. Abdelhameed
Keyword(s):  
Tumor Growth ◽  
Anticancer Agent ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
And Storage ◽  
Organic Framework

A new composite (METase@UiO-66) was prepared froml-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared tol-methioninase. Moreover,in vivoexperiments showed that the drug inhibited tumor growth in mice.

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Multi-modal channel cancer chemotherapy by 2D functional gadolinium metal-organic framework

2020 ◽  
Author(s):  
Jiale Xia ◽  
Yumeng Xue ◽  
Bo Lei ◽  
Lingling Xu ◽  
Mingzi Sun ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Tumor Tissue ◽  
Tumor Imaging ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
High Surface ◽  
Superior Performance ◽  
Metal Organic ◽  
Organic Framework

Abstract Two-dimensional (2D) nanomaterials generally exhibit enhanced physiochemical and biological functions in biomedical applications due to their high surface-to-volume ratio and surface charge. Conventional cancer chemotherapy based on nanomaterials has been hindered by their low drug loading and poor penetration in tumor tissue. To overcome these difficulties, the novel materials systems are urgently needed. Hereby, the lanthanide-based porphyrin metal organic framework (MOF) nanosheets with promising cancer imaging/chemotherapy capacities are fabricated, which displays superior performance in the drug loading and tumor tissue penetration. The biodegradable PPF-Gd nanosheets deliver an ultrahigh drug loading (>1500%) and demonstrate the stable and highly sensitive stimuli-responsive degradation/release for multimodal tumor imaging and cancer chemotherapy. Meanwhile, PPF-Gd NSs also exhibits excellent fluorescence and magnetic resonance imaging capability in vitro and in vivo. Compared to the traditional DOX chemotherapy, the in vivo results confirm the evident suppression of the tumor growth by the PPF-Gd/DOX drug delivery system with negligible side effects. This work further supports the potential of lanthanide-based MOF nanomaterials as biodegradable systems to promote the cancer theranostics technology development in the future.

scholarly journals γ-Cyclodextrin Metal-Organic Framework as a Carrier to Deliver Triptolide for the Treatment of Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Zhe Li ◽  
Gang Yang ◽  
Rong Wang ◽  
Yuanyuan Wang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Water Solubility ◽  
Metal Organic Framework ◽  
Cell Internalization ◽  
The Poor ◽  
Metal Organic ◽  
Tumor Drugs ◽  
Organic Framework

Abstract Triptolide (TPL) has been employed to treat hepatocellular carcinoma (HCC). However, the poor water-solubility of TPL restrict its applications. Therefore, we prepared TPL loaded cyclodextrin-based metal-organic framework (TPL@CD-MOF) to improve the solubility and bioavailability of TPL, thus enhancing the anti-tumor effect on HCC. The BET surface and the pore size of TPL@CD-MOF were 1134.5 m2·g−1 and 1.6 nm, respectively. The results of XRD indicated that TPL in TPL@CD-MOF was encapsuled. TPL@CD-MOF showed a slower release than free TPL in vitro. Moreover, the CD-MOF improved the cell internalization and bioavailability of TPL. TPL@CD-MOF also showed higher anti-tumor efficacy in vitro and in vivo compared to free TPL. As a carrier, CD-MOF improved the solubility and bioavailability of TPL. In addition, TPL@CD-MOF exhibited improved anti-tumor effects in vitro and in vivo, indicating great potential as a carrier for insoluble anti-tumor drugs.

scholarly journals Treatment of Acute Kidney Injury Using a Dual Enzyme Embedded Metal-organic Framework-mediated Cascade That Catalyzes in Vivo ROS Scavenging

2021 ◽  
Author(s):  
Xinyue Hou ◽  
Jianxiang Shi ◽  
Jie Zhang ◽  
Zhigang Wang ◽  
Sen Zhang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Protective Effect ◽  
Metal Organic Framework ◽  
Antioxidant Properties ◽  
Kidney Injury ◽  
Intracellular Enzyme ◽  
Metal Organic ◽  
Enzyme Delivery ◽  
Organic Framework

Abstract Background: Significant advances have been made in recent years to utilize natural enzymes with antioxidant properties for the treatment of acute kidney injury (AKI). However, these enzymes have limited clinical utility due to their limited cellular uptake, poor pharmacokinetic properties, and suboptimal stability. We prepared a novel biomimetic mineralization approach to overcome these limitations.Results: Catalase (CAT) and superoxide dismutase (SOD) were encapsulated in a zeolitic imidazolate framework-8 (ZIF-8), then this SOD@CAT@ZIF-8 complex was anchored with MPEG2000-COOH to yield an MPEG2000-SOD@CAT@ZIF-8 (PSCZ) composite. This composite was then utilized as a stable tool with antioxidant properties for the integrated cascade-based treatment of AKI, remarkably improved intracellular enzyme delivery. The PSCZ composite showed a significantly relieve ability of H2O2 induced ROS and prevented apoptosis in HEK293 cells. In vivo, this composite showed a protective effect in the cisplatin-induced AKI mouse model. In addition, PSCZ treatment mitigated renal dysfunction and histological injury, like tubulointerstitial infiltration. RNA sequencing results further confirmed the protective effect of PSCZ and the potential molecular mechanism was revealed. PSCZ treatment reduced renal inflammation and inflammatory gene expression and ameliorated increased apoptosis and inflammatory infiltration of renal tubules. Moreover, PSCZ administration regulated renal injury via the p53 signaling pathway. These renoprotective effects of PSCZ treatment were more potent in CP-AKI mice than those of SOD or CAT alone. This dual-enzyme-embedded metal-organic framework was able to scavenge reactive oxygen species synergistically and effectively. Conclusion: PSCZ can remarkably improve intracellular enzyme delivery, and it can be used as a stable tool with antioxidant properties for the integrated cascade-based treatment of AKI. The ZIF-8-based “armor plating” represents an effective means of shielding enzymes with improved therapeutic utility to guide the precision medicine-based treatment of AKI.

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