A distinctive mitochondrion-targeting, in situ-activatable near-infrared fluorescent probe for visualizing sulfur dioxide derivatives and their fluctuations in vivo

2020 ◽  
Vol 8 (9) ◽  
pp. 1914-1921 ◽  
Author(s):  
Lintao Zeng ◽  
Tianhong Chen ◽  
Bao-Quan Chen ◽  
Hou-Qun Yuan ◽  
Ruilong Sheng ◽  
...  
Keyword(s):  
Sulfur Dioxide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Mitochondria Targeting

A mitochondria-targeting and in situ-activatable near-infrared fluorescent probe has been developed for imaging sulfur dioxide derivatives and their fluctuations in vivo.

High-Quantum-Yield Mitochondria-Targeting Near-Infrared Fluorescent Probe for Imaging Native Hypobromous Acid in Living Cells and in Vivo

2017 ◽  
Vol 89 (3) ◽  
pp. 1787-1792 ◽  
Author(s):  
Xiaojun Liu ◽  
Aishan Zheng ◽  
Dongrui Luan ◽  
Xiaoting Wang ◽  
Fanpeng Kong ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
High Quantum Yield ◽  
High Quantum ◽  
Hypobromous Acid ◽  
Mitochondria Targeting

A near-infrared multifunctional fluorescent probe with an inherent tumor-targeting property for bioimaging

2015 ◽  
Vol 51 (58) ◽  
pp. 11721-11724 ◽  
Author(s):  
Xu Zhao ◽  
Yang Li ◽  
Di Jin ◽  
Yuzhi Xing ◽  
Xilong Yan ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Mitochondria Targeting

A mitochondria-targeting near-infrared switchable probe for in vitro and in vivo tumor-targeting imaging.

scholarly journals A Fast-Response Red Shifted Fluorescent Probe for Detection of H2S in Living Cells

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 437 ◽  
Author(s):  
Ismail Ismail ◽  
Zhuoyue Chen ◽  
Xiuru Ji ◽  
Lu Sun ◽  
Long Yi ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Redox Homeostasis ◽  
Fast Response ◽  
Living Cells ◽  
Live Cells ◽  
Minimal Damage ◽  
Auto Fluorescence ◽  
Mitochondria Targeting

Near-infrared (NIR) fluorescent probes are attractive tools for bioimaging applications because of their low auto-fluorescence interference, minimal damage to living samples, and deep tissue penetration. H2S is a gaseous signaling molecule that is involved in redox homeostasis and numerous biological processes in vivo. To this end, we have developed a new red shifted fluorescent probe 1 to detect physiological H2S in live cells. The probe 1 is based on a rhodamine derivative as the red shifted fluorophore and the thiolysis of 7-nitro 1,2,3-benzoxadiazole (NBD) amine as the H2S receptor. The probe 1 displays fast fluorescent enhancement at 660 nm (about 10-fold turn-ons, k2 = 29.8 M−1s−1) after reacting with H2S in buffer (pH 7.4), and the fluorescence quantum yield of the activated red shifted product can reach 0.29. The probe 1 also exhibits high selectivity and sensitivity towards H2S. Moreover, 1 is cell-membrane-permeable and mitochondria-targeting, and can be used for imaging of endogenous H2S in living cells. We believe that this red shifted fluorescent probe can be a useful tool for studies of H2S biology.

scholarly journals An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo

2016 ◽  
Vol 7 (2) ◽  
pp. 1588-1593 ◽  
Author(s):  
Haibin Xiao ◽  
Ping Li ◽  
Wei Zhang ◽  
Bo Tang
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Live Cells ◽  
Mitochondria Targeting ◽  
Ratiometric Fluorescent Probe

We describe a new mitochondria-targeting fluorescent probeMCY-BF2that is singularly sensitive and specifically responsive to mitochondrial polarity.

A near-infrared fluorescent probe targeting mitochondria for sulfite detection and its application in food and biology

2021 ◽  
Author(s):  
Jianbin Chao ◽  
Zhuo Wang ◽  
Yongbin Zhang ◽  
Fangjun Huo ◽  
Caixia Yin
Keyword(s):  
Cardiovascular Diseases ◽  
Sulfur Dioxide ◽  
Human Health ◽  
Fluorescent Probe ◽  
Respiratory Diseases ◽  
Near Infrared ◽  
Air Pollutant ◽  
Great Harm

Abstract: Sulfur dioxide (SO2) is the main air pollutant in the environment, causing great harm to human health. Abnormal SO2 levels are usually associated with some respiratory diseases, cardiovascular diseases,...

A smart mitochondria-targeting TP-NIR fluorescent probe for selective and sensitive sensing H2S in living cells and mice

2021 ◽  
Author(s):  
Qiaomei Yang ◽  
Liyi Zhou ◽  
Longpeng Peng ◽  
Gangqiang Yuan ◽  
Haiyuan Ding ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Signal Molecules ◽  
Two Photon ◽  
Mitochondria Targeting

Hydrogen sulfide (H2S) is one of the important gaseous signal molecules and plays key roles in various biologically crucial processes. In this work, we report a novel two-photon near-infrared (TP-NIR)...

scholarly journals An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yongchao Wang ◽  
Ningqiang Gong ◽  
Chi Ma ◽  
Yuxuan Zhang ◽  
Hong Tan ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Light ◽  
Immune Memory ◽  
Toll Like Receptor ◽  
Tumour Site ◽  
Adjuvant Effect ◽  
Cancer Vaccination ◽  
Tumour Metastasis

AbstractImmunological adjuvants are essential for successful cancer vaccination. However, traditional adjuvants have some limitations, such as lack of controllability and induction of systemic toxicity, which restrict their broad application. Here, we present a light-activable immunological adjuvant (LIA), which is composed of a hypoxia-responsive amphiphilic dendrimer nanoparticle loaded with chlorin e6. Under irradiation with near-infrared light, the LIA not only induces tumour cell lysis and tumour antigen release, but also promotes the structural transformation of 2-nitroimidazole containing dendrimer to 2-aminoimidazole containing dendrimer which can activate dendritic cells via the Toll-like receptor 7-mediated signaling pathway. The LIA efficiently inhibits both primary and abscopal tumour growth and induces strong antigen-specific immune memory effect to prevent tumour metastasis and recurrence in vivo. Furthermore, LIA localizes the immunological adjuvant effect at the tumour site. We demonstrate this light-activable immunological adjuvant offers a safe and potent platform for in situ cancer vaccination.

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