hypobromous acid
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2021 ◽  
pp. 117787
Author(s):  
Quanzhen Liu ◽  
Xiong Xu ◽  
Jianjie Fu ◽  
Yanjun Du ◽  
Lihua Lin ◽  
...  

2021 ◽  
Author(s):  
Martina Paumann-Page ◽  
Nikolaus Ferdinand Kienzl ◽  
Jyoti Motwani ◽  
Boushra Boushra Bathish ◽  
Louise N Paton ◽  
...  

Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxidasin acts in cancer cells. We have analyzed peroxidasin protein expression and activity in eight metastatic melanoma cell lines using an ELISA developed with an in-house peroxidasin binding protein. RNAseq data analysis confirmed high peroxidasin mRNA expression in the five cell lines classified as invasive and low expression in the three non-invasive cell lines. Protein levels of peroxidasin were higher in the cell lines with an invasive phenotype. Active peroxidasin was secreted to the cell culture medium, where it accumulated over time, and peroxidasin protein levels in the medium were also much higher in invasive than non-invasive cell lines. The only well-established physiological role of peroxidasin is in the formation of a sulfilimine bond, which cross-links collagen IV in basement membranes via catalyzed oxidation of bromide to hypobromous acid. We found that peroxidasin secreted from melanoma cells formed sulfilimine bonds in uncross-linked collagen IV, confirming peroxidasin activity and hypobromous acid formation. Moreover, 3-bromotyrosine, a stable product of hypobromous acid reacting with tyrosine residues, was detected in invasive melanoma cells, substantiating that their expression of peroxidasin generates hypobromous acid, and showing that it does not exclusively react with collagen IV, but also with other biomolecules.


Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 363
Author(s):  
Yuyu Fang ◽  
Wim Dehaen

Reactive oxygen species (ROS) have been implicated in numerous pathological processes and their homeostasis facilitates the dynamic balance of intracellular redox states. Among ROS, hypobromous acid (HOBr) has a high similarity to hypochlorous acid (HOCl) in both chemical and physical properties, whereas it has received relatively little attention. Meanwhile, selective recognition of endogenous HOBr suffers great challenges due to the fact that the concentration of this molecule is much lower than that of HOCl. Fluorescence-based detection systems have emerged as very important tools to monitor biomolecules in living cells and organisms owing to distinct advantages, particularly the temporal and spatial sampling for in vivo imaging applications. To date, the development of HOBr-specific fluorescent probes is still proceeding quite slowly, and the research related to this area has not been systematically summarized. In this review, we are the first to review the progress made so far in fluorescent probes for selective recognition and detection of HOBr. The molecular structures, sensing mechanisms, and their successful applications of these probes as bioimaging agents are discussed here in detail. Importantly, we hope this review will call for more attention to this rising field, and that this could stimulate new future achievements.


2021 ◽  
Author(s):  
Jian Zhang ◽  
kaiqiang Liu ◽  
Jingwen Li ◽  
Yingying Xie ◽  
Yong Li ◽  
...  

In virtue of the formation of Se=N, ABT-Se and NDI-Se were developed to detect and visualize endogenous HOBr in live cells. Specifically, the upregulation of HOBr was monitored by NDI-Se...


Author(s):  
Rui Pang ◽  
Yugo Miseki ◽  
Kazuhiro Sayama

Photocatalytic production of hypobromous acid (HBrO) by oxidation of bromide (Br−) under simulated solar light was successfully obtained over visible-light active photocatalysts. Among all photocatalysts, the platinum (Pt) cocatalyst-loaded tungsten...


The Analyst ◽  
2021 ◽  
Author(s):  
Nathaniel Finney ◽  
Yali Wang ◽  
Yuan Zhang ◽  
Lijun Yang ◽  
Huiyuan Wu

Developing rapid, sensitive, selective fluorescent probes for HOBr detection and imaging is of great importance. It is a reactive oxygen species (ROS) with numerous biological roles: excessive or misplaced generation...


2020 ◽  
Vol 320 ◽  
pp. 128583 ◽  
Author(s):  
Pan Jia ◽  
Dongmei Liu ◽  
Zihan Zhuang ◽  
Leyang Qu ◽  
Caiyun Liu ◽  
...  

2020 ◽  
Vol 315 ◽  
pp. 128125 ◽  
Author(s):  
Xiuzhu Huo ◽  
Xia Wang ◽  
Ran Yang ◽  
Zhaohui Li ◽  
Yuanqiang Sun ◽  
...  

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