Intracellular delivery of therapeutic proteins through N-terminal site-specific modification

2020 ◽  
Vol 56 (77) ◽  
pp. 11473-11476
Author(s):  
Si Si Liew ◽  
Chengwu Zhang ◽  
Jie Zhang ◽  
Hongyan Sun ◽  
Lin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Proteins ◽  
Intracellular Delivery ◽  
Rnase A ◽  
Targeted Cancer Therapy ◽  
Site Specific ◽  
Specific Modification ◽  
A Cell ◽  
Terminal Site ◽  
Labeling Strategies

Adopting orthogonal dual-labeling strategies, a cell-permeable RNase A prodrug was designed for ROS-responsive targeted cancer therapy.

scholarly journals Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy

Oncotarget ◽  
2015 ◽  
Vol 6 (42) ◽  
pp. 44179-44190 ◽  
Author(s):  
Xiang-Jun Tang ◽  
Xu-Yong Sun ◽  
Kuan-Ming Huang ◽  
Li Zhang ◽  
Zhuo-Shun Yang ◽  
...  
Keyword(s):  
T Cell ◽  
Cancer Therapy ◽  
Therapeutic Potential ◽  
Targeted Cancer Therapy ◽  
Car T Cell ◽  
Car T ◽  
A Cell

scholarly journals A Novel Immuno-RNase Based on Engineered RNase A Variants for Targeted Cancer Therapy

2020 ◽  
Author(s):  
Masoume Vakili Azghandi ◽  
Mohammadreza Nassiri ◽  
Veysel Kayser ◽  
Ali Javadmanesh ◽  
Shahrokh Ghovvati
Keyword(s):  
Cancer Therapy ◽  
Rnase A ◽  
Targeted Cancer Therapy

Abstract The authors have requested that this preprint be removed from Research Square.

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

2014 ◽  
Vol 53 (49) ◽  
pp. 13444-13448 ◽  
Author(s):  
Ming Wang ◽  
Shuo Sun ◽  
Caleb I. Neufeld ◽  
Bernardo Perez-Ramirez ◽  
Qiaobing Xu
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Protein Modification ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Targeted Cancer Therapy

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

2014 ◽  
Vol 126 (49) ◽  
pp. 13662-13666 ◽  
Author(s):  
Ming Wang ◽  
Shuo Sun ◽  
Caleb I. Neufeld ◽  
Bernardo Perez-Ramirez ◽  
Qiaobing Xu
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Protein Modification ◽  
Reactive Oxygen ◽  
Intracellular Delivery ◽  
Oxygen Species ◽  
Targeted Cancer Therapy

Clustered nanobody–drug conjugates for targeted cancer therapy

2020 ◽  
Vol 56 (65) ◽  
pp. 9344-9347
Author(s):  
Tiantian Wu ◽  
Manman Liu ◽  
Hai Huang ◽  
Yaping Sheng ◽  
Haihua Xiao ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Drug Efficacy ◽  
Targeted Cancer Therapy ◽  
Site Specific ◽  
Drug Conjugate ◽  
Drug Conjugates ◽  
A Site

A novel clustered nanobody–drug conjugate is constructed by a site-specific ligation of a nanobody to dendrimeric-lysine, which enhances drug efficacy and reduces side-effects.

scholarly journals Developing chemically modified redox-responsive proteins as smart therapeutics

2019 ◽  
Vol 55 (35) ◽  
pp. 5163-5166 ◽  
Author(s):  
Qiao Tang ◽  
Jianxue Wang ◽  
Ying Jiang ◽  
Meining Zhang ◽  
Jin Chang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Rnase A ◽  
Live Cells ◽  
Targeted Cancer Therapy ◽  
Chemically Modified ◽  
Redox Responsive

The chemically modified redox-responsive RNase A–NSA could be selectively activated by up-regulated GSH in live cells for targeted cancer therapy.

Thermal and magnetic dual-responsive liposomes with a cell-penetrating peptide-siRNA conjugate for enhanced and targeted cancer therapy

2016 ◽  
Vol 146 ◽  
pp. 607-615 ◽  
Author(s):  
Yanfang Yang ◽  
Xiangyang Xie ◽  
Xueqing Xu ◽  
Xuejun Xia ◽  
Hongliang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cell Penetrating Peptide ◽  
Targeted Cancer Therapy ◽  
Dual Responsive ◽  
Cell Penetrating ◽  
A Cell

Polyethyleneimine coated nanogels for the intracellular delivery of RNase A for cancer therapy

2018 ◽  
Vol 340 ◽  
pp. 32-41 ◽  
Author(s):  
Neda Kordalivand ◽  
Dandan Li ◽  
Nataliia Beztsinna ◽  
Javier Sastre Torano ◽  
Enrico Mastrobattista ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Intracellular Delivery ◽  
Rnase A

scholarly journals A Novel Immuno-RNase Based on Engineered RNase A Variants for Targeted Cancer Therapy

2020 ◽  
Author(s):  
Masoume Vakili Azghandi ◽  
Mohammadreza Nassiri ◽  
Veysel Kayser ◽  
Ali Javadmanesh ◽  
Shahrokh Ghovvati
Keyword(s):  
Cancer Therapy ◽  
Rnase A ◽  
Targeted Cancer Therapy

Abstract The authors have requested that this preprint be removed from Research Square.

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