Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

2021 ◽  
Vol 50 (7) ◽  
pp. 2627-2638
Author(s):  
Tina P. Andrejević ◽  
Ivana Aleksic ◽  
Marta Počkaj ◽  
Jakob Kljun ◽  
Dusan Milivojevic ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation

Antifungal copper(ii) complexes with pyridine-4,5-dicarboxylate esters show the ability to inhibit the filamentation and biofilm formation of Candida albicans, and efficiently prevent the adhesion of this fungus.

Enterococcus faecalis Cell-Free Supernatant Inhibits Hyphal Morphogenesis and Biofilm Formation in Candida albicans

2018 ◽  
Vol 46 (2) ◽  
pp. 128-135
Author(s):  
Mohamed Hassan ◽  
Yasmine Tartor ◽  
Ashour Ashour ◽  
Elmowalid Elmowalid
Keyword(s):  
Candida Albicans ◽  
Enterococcus Faecalis ◽  
Biofilm Formation ◽  
Cell Free Supernatant ◽  
Hyphal Morphogenesis

scholarly journals In VitroAnalyses of the Effects of Heparin and Parabens on Candida albicans Biofilms and Planktonic Cells

2011 ◽  
Vol 56 (1) ◽  
pp. 148-153 ◽  
Author(s):  
Marisa H. Miceli ◽  
Stella M. Bernardo ◽  
T. S. Neil Ku ◽  
Carla Walraven ◽  
Samuel A. Lee
Keyword(s):  
Candida Albicans ◽  
Metabolic Activity ◽  
Biofilm Formation ◽  
High Dose ◽  
Dependent Manner ◽  
Planktonic Cells ◽  
Content Type ◽  
Heparin Sodium ◽  
The Individual

ABSTRACTInfections and thromboses are the most common complications associated with central venous catheters. Suggested strategies for prevention and management of these complications include the use of heparin-coated catheters, heparin locks, and antimicrobial lock therapy. However, the effects of heparin onCandida albicansbiofilms and planktonic cells have not been previously studied. Therefore, we sought to determine thein vitroeffect of a heparin sodium preparation (HP) on biofilms and planktonic cells ofC. albicans. Because HP contains two preservatives, methyl paraben (MP) and propyl paraben (PP), these compounds and heparin sodium without preservatives (Pure-H) were also tested individually. The metabolic activity of the mature biofilm after treatment was assessed using XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] reduction and microscopy. Pure-H, MP, and PP caused up to 75, 85, and 60% reductions of metabolic activity of the mature preformedC. albicansbiofilms, respectively. Maximal efficacy against the mature biofilm was observed with HP (up to 90%) compared to the individual compounds (P< 0.0001). Pure-H, MP, and PP each inhibitedC. albicansbiofilm formation up to 90%. A complete inhibition of biofilm formation was observed with HP at 5,000 U/ml and higher. When tested against planktonic cells, each compound inhibited growth in a dose-dependent manner. These data indicated that HP, MP, PP, and Pure-H havein vitroantifungal activity againstC. albicansmature biofilms, formation of biofilms, and planktonic cells. Investigation of high-dose heparin-based strategies (e.g., heparin locks) in combination with traditional antifungal agents for the treatment and/or prevention ofC. albicansbiofilms is warranted.

Non-antifungal drugs inhibit growth, morphogenesis and biofilm formation in Candida albicans

2021 ◽  
Author(s):  
Gunderao Hanumantrao Kathwate ◽  
Ravikumar Bapurao Shinde ◽  
S. Mohan Karuppayil
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Antifungal Drugs

scholarly journals Eap1p, an Adhesin That Mediates Candida albicans Biofilm Formation In Vitro and In Vivo

2007 ◽  
Vol 6 (6) ◽  
pp. 931-939 ◽  
Author(s):  
Fang Li ◽  
Michael J. Svarovsky ◽  
Amy J. Karlsson ◽  
Joel P. Wagner ◽  
Karen Marchillo ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Cell Adhesion ◽  
Biofilm Formation ◽  
Fungal Infections ◽  
Gene Dosage ◽  
Venous Catheter ◽  
Flow Chamber ◽  
Dependent Manner

ABSTRACT Candida albicans is the leading cause of systemic fungal infections in immunocompromised humans. The ability to form biofilms on surfaces in the host or on implanted medical devices enhances C. albicans virulence, leading to antimicrobial resistance and providing a reservoir for infection. Biofilm formation is a complex multicellular process consisting of cell adhesion, cell growth, morphogenic switching between yeast form and filamentous states, and quorum sensing. Here we describe the role of the C. albicans EAP1 gene, which encodes a glycosylphosphatidylinositol-anchored, glucan-cross-linked cell wall protein, in adhesion and biofilm formation in vitro and in vivo. Deleting EAP1 reduced cell adhesion to polystyrene and epithelial cells in a gene dosage-dependent manner. Furthermore, EAP1 expression was required for C. albicans biofilm formation in an in vitro parallel plate flow chamber model and in an in vivo rat central venous catheter model. EAP1 expression was upregulated in biofilm-associated cells in vitro and in vivo. Our results illustrate an association between Eap1p-mediated adhesion and biofilm formation in vitro and in vivo.

Effect of aqueous extract from Neem (Azadirachta indica A. Juss) on hydrophobicity, biofilm formation and adhesion in composite resin by Candida albicans

2006 ◽  
Vol 51 (6) ◽  
pp. 482-490 ◽  
Author(s):  
Sheila R.B. Polaquini ◽  
Terezinha I.E. Svidzinski ◽  
Carlos Kemmelmeier ◽  
André Gasparetto
Keyword(s):  
Candida Albicans ◽  
Aqueous Extract ◽  
Azadirachta Indica ◽  
Biofilm Formation ◽  
Composite Resin

scholarly journals Suppression of Fluconazole Resistant Candida albicans Biofilm Formation and Filamentation by Methylindole Derivatives

2018 ◽  
Vol 9 ◽  
Author(s):  
Jin-Hyung Lee ◽  
Yong-Guy Kim ◽  
Vivek Kumar Gupta ◽  
Ranjith Kumar Manoharan ◽  
Jintae Lee
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Fluconazole Resistant
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