A pH and UCST thermo-responsive tri-block copolymer (PAA-b-PDMA-b-P(AM-co-AN)) with micellization and gelatinization in aqueous media for drug release

2020 ◽  
Vol 44 (34) ◽  
pp. 14551-14559
Author(s):  
Cheng Zhou ◽  
Yan Chen ◽  
Mingjun Huang ◽  
Yi Ling ◽  
Liming Yang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Drug Release ◽  
Acrylic Acid ◽  
Triblock Copolymer ◽  
Drug Carrier ◽  
Aqueous Media ◽  
Abc Triblock Copolymer ◽  
Carrier Systems ◽  
Drug Carrier Systems ◽  
Poly Acrylamide

A brand new pH and thermo-responsive amphiphilic ABC triblock copolymer of poly(acrylic acid)-block-poly(N,N-dimethyl acrylamide)-block-poly(acrylamide-co-acrylonitrile) (PAA-b-PDMA-b-P(AM-co-AN)) was applied as drug carrier systems.

THE DRUG RELEASE FROM LIPOSOMAL CARRIER WITHIN THE CHITOSAN MATRIX

2009 ◽  
Vol 21 (02) ◽  
pp. 107-114 ◽  
Author(s):  
Hongsen Chiang ◽  
Yi-Cheng Huang ◽  
Huei-Yu Yeh ◽  
Szu-Yi Yeh ◽  
Yi-You Huang
Keyword(s):  
Drug Release ◽  
Tissue Regeneration ◽  
Drug Carrier ◽  
Sustained Drug Release ◽  
Hydrophilic Drugs ◽  
Chitosan Matrix ◽  
Injectable Scaffold ◽  
Regulation Of Growth ◽  
Carrier Systems ◽  
Drug Carrier Systems

The release and regulation of growth factors are very important in the tissue regeneration. Optimal and suitable drug carrier systems combined with scaffold are needed to be exploited. In this study, we developed an injectable scaffold incorporated with drug release system for tissue regeneration. Hydrophilic or hydrophobic drugs can be encapsulated into liposomes and then dispersed in the temperature-reversible chitosan-glycerophosphate (GP) hydrogel. Experimental results show that liposomes provide excellent sustained drug release from chitosan matrix when compared with that of free drugs, especially for hydrophilic drugs. The negative charge of the liposome will complex with the positive charge of the chitosan's protonized amine group that results in controlling the drugs release.

Lipids-based drug carrier systems by dense gas technology: A review

2012 ◽  
Vol 188 ◽  
pp. 1-14 ◽  
Author(s):  
Chau Chun Beh ◽  
Raffaella Mammucari ◽  
Neil R. Foster
Keyword(s):  
Drug Carrier ◽  
Dense Gas ◽  
Carrier Systems ◽  
Drug Carrier Systems

Biodegradable Polymers as Drug Carrier Systems

2001 ◽  
Author(s):  
Abraham Domb ◽  
Neeraj Kumar ◽  
Tzviel Sheskin ◽  
Alfonso Bentolila ◽  
Joram Slager ◽  
...  
Keyword(s):  
Biodegradable Polymers ◽  
Drug Carrier ◽  
Carrier Systems ◽  
Drug Carrier Systems

Anticancer Agents: Drug Carrier Systems

2015 ◽  
pp. 228-241
Author(s):  
Hiroyuki Koide ◽  
Tomohiro Asai ◽  
Kosuke Shimizu ◽  
Naoto Oku
Keyword(s):  
Anticancer Agents ◽  
Drug Carrier ◽  
Carrier Systems ◽  
Drug Carrier Systems

scholarly journals Integrin-Targeting Peptides for the Design of Functional Cell-Responsive Biomaterials

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 307 ◽  
Author(s):  
Junwei Zhao ◽  
Federica Santino ◽  
Daria Giacomini ◽  
Luca Gentilucci
Keyword(s):  
Cell Surface ◽  
Smart Materials ◽  
Drug Carrier ◽  
Peptide Ligands ◽  
Stimuli Responsive ◽  
Cellular Functions ◽  
Surface Receptors ◽  
Integrin Ligands ◽  
Carrier Systems ◽  
Drug Carrier Systems

Integrins are a family of cell surface receptors crucial to fundamental cellular functions such as adhesion, signaling, and viability, deeply involved in a variety of diseases, including the initiation and progression of cancer, of coronary, inflammatory, or autoimmune diseases. The natural ligands of integrins are glycoproteins expressed on the cell surface or proteins of the extracellular matrix. For this reason, short peptides or peptidomimetic sequences that reproduce the integrin-binding motives have attracted much attention as potential drugs. When challenged in clinical trials, these peptides/peptidomimetics let to contrasting and disappointing results. In the search for alternative utilizations, the integrin peptide ligands have been conjugated onto nanoparticles, materials, or drugs and drug carrier systems, for specific recognition or delivery of drugs to cells overexpressing the targeted integrins. Recent research in peptidic integrin ligands is exploring new opportunities, in particular for the design of nanostructured, micro-fabricated, cell-responsive, stimuli-responsive, smart materials.

Permeability of CardiothanerR-51 (AvcothanerR-51) and SilasticR500–1 to Lipophilic Drugs

1987 ◽  
Vol 110 ◽  
Author(s):  
Stephen D. Bruck ◽  
M. Kojima
Keyword(s):  
Medical Devices ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Basic Process ◽  
Molecular Weights ◽  
Polymeric Biomaterials ◽  
Physico Chemical ◽  
Biological Performance ◽  
Carrier Systems ◽  
Drug Carrier Systems

Sorption processes (adsorption, absorption, permeation) are of considerable importance in the physico-chemical and biological performance of polymeric biomaterials, especially in cardiovascular applications, and in various controlled drug release and drug carrier systems [1,2]. Transport of molecules of widely ranging molecular weights through synthetic as well as biologic membranes represents a basic process in the performance of many medical devices.

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