Cancer photocytotoxicity and anti-inflammatory response of cis-A2B2 type meso-p-nitrophenyl and p-hydroxyphenyl porphyrin and its zinc(II) complex: A synthetic alternative to the THPP synthon.

2021 ◽  
Author(s):  
Debdulal Sharma ◽  
Zeaul Hoque Mazumder ◽  
Devashish Sengupta ◽  
Avinaba Mukherjee ◽  
Mahuya Sengupta ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Inflammatory Response ◽  
Porphyrin Derivative ◽  
Anti Inflammatory

This work establishes that in comparison with the popular synthetic synthon, tetra-p-hydroxyphenyl porphyrin (THPP), used for developing various cancer photodynamic therapy (PDT) agents, the cis-A2B2 type of porphyrin derivative, synthesized...

scholarly journals Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1704
Author(s):  
Diego Angosto-Bazarra ◽  
Cristina Molina-López ◽  
Alejandro Peñín-Franch ◽  
Laura Hurtado-Navarro ◽  
Pablo Pelegrín
Keyword(s):  
Inflammatory Response ◽  
Small Molecules ◽  
Mechanism Of Action ◽  
Inflammatory Diseases ◽  
Inflammasome Activation ◽  
Chronic Inflammatory Diseases ◽  
Anti Inflammatory ◽  
Inhibitory Molecules ◽  
Inflammasome Inhibitors

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

scholarly journals Flaxseed orbitides, linusorbs, inhibit LPS-induced THP-1 macrophage inflammation

RSC Advances ◽  
2020 ◽  
Vol 10 (38) ◽  
pp. 22622-22630
Author(s):  
Xian-Guo Zou ◽  
Youn Young Shim ◽  
Jae Youl Cho ◽  
Deok Jeong ◽  
Jian Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cyclic Peptides ◽  
Underlying Mechanism ◽  
Anti Inflammatory

Linusorbs (flax orbitides) are a family of plant cyclic peptides. We investigate the anti-inflammatory activities of two different linusorbs ([1–9-NaC]-linusorb B2 and [1–9-NaC]-linusorb B3) and the underlying mechanism of this inflammatory response.

Sign in / Sign up

Export Citation Format

Share Document