scholarly journals Controlled Ring-Opening Polymerization of N-(3-tert-Butoxy-3-oxopropyl) Glycine Derived N-Carboxyanhydrides towards Well-defined Peptoid-based Polyacids

2021 ◽  
Author(s):  
Donghui Zhang ◽  
Bailee Barrett ◽  
Garrett Sternhagen
Keyword(s):  
Carboxylic Acid ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Supramolecular Assemblies ◽  
Stimuli Responsive ◽  
Carboxylic Acid Groups

Polypeptoids bearing carboxylic acid groups on the N-substituent are useful building blocks for the construction of peptidomimetic supramolecular assemblies with stimuli-responsive properties. Towards this end, N-(3-tert-butoxy-3-oxopropyl) glycine derived N-carboxyanhydride (tBuO2Pr-NCA)...

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

Biodegradable Polymers Derived from Amino Acids for Biological Applications

2010 ◽  
Vol 76 ◽  
pp. 30-35 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Ilanit Hagag ◽  
Michal Kolitz ◽  
Abraham J. Domb ◽  
Jeoshua Katzhendler
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Microwave Assisted Synthesis ◽  
Hydroxy Acids ◽  
Natural Amino Acids ◽  
Direct Condensation ◽  
Positively Charged

Optically active α-hydroxy acids derived from amino acids have been synthesized and polymerized into new biodegradable polyesters. The variety of functional side chains enables the design of positively charged, negatively charged, hydrophobic and hydrophilic chiral building blocks or any combination of these constituents. Hydroxy acids of 15 natural amino acids were prepared with retention of configuration using a straightforward and reliable method of diazotization of α-amino acids. Polyesters were synthesized from these hydroxy acids by a number of methods: direct condensation in bulk, microwave assisted synthesis and ring opening polymerization. The molecular weight of the prepared polymers ranges between 2000 to 5000Da for the direct condensation and the microwave methods, whereas the ring opening polymerization results in high molecular weight polymers (20000 to 30000Da). The polymers were analyzed for their optical activity (Circular Dichroism Spectroscopy), thermal properties (DSC), solubility, molecular weight and polydispersity (GPC), and aqueous degradation. These polymers were tested for their compatibility to neuronal cells growth and differentiation.

scholarly journals Zirconium (IV) Acetylacetonate: Ring-Opening Initiator Mediating One-Step Synthesis of Biodegradable Polyacids

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Piotr Dobrzyński ◽  
Małgorzata Pastusiak ◽  
Joanna Jaworska ◽  
Bożena Kaczmarczyk ◽  
Michał Kwiecień ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Acid Derivative ◽  
Ring Opening ◽  
Active Catalyst ◽  
Ring Opening Polymerization ◽  
Cyclic Carbonate ◽  
Trimethylene Carbonate ◽  
Step Method ◽  
Polymerization Mechanism ◽  
One Step

Biodegradable polyacid is obtained in one-step ring-opening polymerization (ROP) of carboxylic-acid-functionalized six-membered cyclic carbonate mediated with zirconium (IV) acetylacetonate. Exemplary copolymers with L,L-lactide are described as well. Moreover, zirconium (IV) acetylacetonate is found to be active catalyst of trimethylene carbonate (TMC) ROP in presence of carboxylic acid yielding PTMC end-capped with the acid derivative. Polymerization mechanism is hypothesized demonstrating possibilities of the method in work-saving polycation synthesis and one-step method of conjugate synthesis of well-known biocompatible polyesters and polycarbonates.

Thiourea binding with carboxylic acid promoted cationic ring-opening polymerization

Polymer ◽  
2016 ◽  
Vol 84 ◽  
pp. 293-303 ◽  
Author(s):  
Xiaopei Li ◽  
Qiguo Zhang ◽  
Zhenjiang Li ◽  
Xin Wang ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Cationic Ring Opening Polymerization

Tuning the H-bond donicity boosts carboxylic acid efficiency in ring-opening polymerization

2019 ◽  
Vol 112 ◽  
pp. 799-808 ◽  
Author(s):  
Songquan Xu ◽  
Hui Zhu ◽  
Zhenjiang Li ◽  
Fulan Wei ◽  
Yu Gao ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization

Multi-stimuli responsive supramolecular hydrogels based on Fe3+ and diblock copolymer micelle complexation

2016 ◽  
Vol 7 (7) ◽  
pp. 1405-1412 ◽  
Author(s):  
Zhen Tao ◽  
Kang Peng ◽  
Yujiao Fan ◽  
Yunfei Liu ◽  
Haiyang Yang
Keyword(s):  
Carboxylic Acid ◽  
Uv Irradiation ◽  
Diblock Copolymer ◽  
Biomedical Application ◽  
Stimuli Responsive ◽  
Ferric Ions ◽  
Supramolecular Hydrogel ◽  
Carboxylic Acid Groups ◽  
Copolymer Micelle ◽  
Redox Agents

We report a multi-stimuli responsive supramolecular hydrogel with great potential for biomedical application, which was composed of the micelle-forming diblock copolymer and physically cross-linked by complexation between ferric ions and carboxylic acid groups, exhibiting gel–sol transition caused by UV irradiation, multidentate ligands (EDTA) and redox agents (Na2S2O4).

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