Recent progress in the total synthesis of pyrrole-containing natural products (2011-2020)

2021 ◽  
Author(s):  
Nidhi Singh ◽  
Snigdha Singh ◽  
Sahil Kohli ◽  
Aarushi Singh ◽  
Hannah Asiki ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Total Synthesis ◽  
Chronic Diseases ◽  
Recent Progress ◽  
Structural Complexity

Natural products have long served as a rich resource for drug discovery in the treatment of illnesses and chronic diseases. Among many families exhibiting fascinating structural complexity and impressive bioactivity,...

scholarly journals Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 720
Author(s):  
Satomi Niwayama
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Functional Groups ◽  
Organic Compounds ◽  
Recent Progress ◽  
Aqueous Media ◽  
Building Blocks ◽  
Organic Reactions ◽  
Environmentally Benign ◽  
Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

scholarly journals NATURAL PRODUCTS: FROM TRADITIONAL MEDICINE TO LEAD COMPOUNDS FOR DRUG DEVELOPMENT IN THE 21ST CENTURY

2021 ◽  
pp. 97-104
Author(s):  
Beatriz de las Heras Polo
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
High Throughput Screening ◽  
Structural Complexity ◽  
Cost Benefit ◽  
Bioactive Molecules ◽  
Computational Techniques ◽  
Design And Optimization ◽  
Technological Advances ◽  
Biological Tests

Natural products have historically contributed to drug discovery as a source of bioactive molecules, due to their great diversity and structural complexity. They have provided “lead” molecules for the development of drugs in different therapeutic areas, with a very prominent representation in the treatment of pain and inflammation, coagulation disorders, metabolic disorders, as well as in the treatment of cancer and infectious diseases. In recent decades there has been a paradigm shift in drug discovery strategies that has allowed the identification of new active natural products in therapeutic targets. Combinatorial Chemistry and biological tests (High Throughput Screening), together with the development of computational techniques, have contributed decisively to the design and optimization of libraries of natural product derivatives based on their biological activity. In parallel, technological advances in the field of Omics sciences and in data processing lead to a multidimensional approach in the drug discovery process. These powerful tools will allow the analysis of the pharmacological potential of natural products and their derivatives for the conversion of these molecules to active products with low toxicity. In the Precision Medicine era, natural products continue to be molecules with great potential in pharmaceutical development, since, unlike other therapeutic strategies, they have a favorable cost-benefit ratio, which will allow their future use in this discipline.

scholarly journals Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takuya Imaoka ◽  
Makoto Iwata ◽  
Takafumi Akimoto ◽  
Kazuo Nagasawa
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Structural Complexity ◽  
Marine Alkaloids ◽  
Ring Systems ◽  
Agonistic Activity ◽  
Synthetic Approaches

Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.

Recent progress on the total synthesis of natural products in China

2006 ◽  
Vol 23 (5) ◽  
pp. 772 ◽  
Author(s):  
Qingquan Wu ◽  
Dawei Ma
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Progress

Recent Progress on the Total Synthesis of Natural Products in China

ChemInform ◽  
2007 ◽  
Vol 38 (5) ◽  
Author(s):  
Qingquan Wu ◽  
Dawei Ma
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Progress

Recent Progress in Total Synthesis and Development of Natural Products Using Carbohydrates

ChemInform ◽  
2004 ◽  
Vol 35 (10) ◽  
Author(s):  
Kuniaki Tatsuta
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Progress

ChemInform Abstract: Recent Progress in Total Synthesis and Development of Natural Products Using Carbohydrates

ChemInform ◽  
2010 ◽  
Vol 29 (15) ◽  
pp. no-no
Author(s):  
K. TATSUTA
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Recent Progress

scholarly journals Progress in the Total Synthesis of Rocaglamide

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Xiao-hua Cai ◽  
Bing Xie ◽  
Hui Guo
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Cancer Chemotherapy ◽  
Therapeutic Agent ◽  
Stereoselective Synthesis ◽  
Structural Complexity ◽  
Significant Activity ◽  
Substitution Pattern ◽  
Total Syntheses ◽  
Synthetic Target

The first cyclopenta[b]benzofuran derivative, rocaglamide, from Aglaia elliptifolia, was found to exhibit considerable insecticidal activities and excellent potential as a therapeutic agent candidate in cancer chemotherapy; the genus Aglaia has been subjected to further investigation. Both the structural complexity of rocaglamide and its significant activity make it an attractive synthetic target. Stereoselective synthesis of the dense substitution pattern of these targets is a formidable synthetic challenge: the molecules bear five contiguous stereocenters and cis aryl groups on adjacent carbons. In past years of effort, only a handful of completed total syntheses have been reported, evidence of the difficulties associated with the synthesis of rocaglate natural products. The advance on total synthesis of rocaglamide was mainly reviewed from intramolecular cyclization and biomimetic cycloaddition approach.

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