Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

This perspective article aims to introduce the design principles and recognition strategies of small-molecule fluorescent probes which are applied for the detection of gas signaling molecules including NO, CO and H2S in biological systems.

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Rational design of small molecule fluorescent probes for biological applications

Organic & Biomolecular Chemistry ◽

10.1039/d0ob01131b ◽

2020 ◽

Vol 18 (30) ◽

pp. 5747-5763 ◽

Cited By ~ 5

Author(s):

Joomyung V. Jun ◽

David M. Chenoweth ◽

E. James Petersson

Keyword(s):

Energy Transfer ◽

Small Molecule ◽

Fluorescent Probes ◽

Rational Design ◽

Biological Systems ◽

Biological Applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

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Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems

Analytical Chemistry ◽

10.1021/acs.analchem.7b04234 ◽

2017 ◽

Vol 90 (1) ◽

pp. 533-555 ◽

Cited By ~ 210

Author(s):

Xiaoyun Jiao ◽

Yong Li ◽

Jinye Niu ◽

Xilei Xie ◽

Xu Wang ◽

...

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Biological Systems ◽

Reactive Oxygen ◽

Sulfur Species

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The Design Principles of Small-Molecule Fluorescent Probes for the Detection of Anions

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1052.460 ◽

2014 ◽

Vol 1052 ◽

pp. 460-463 ◽

Cited By ~ 1

Author(s):

Ran Ran Chu

Keyword(s):

Hydrogen Bonds ◽

Small Molecule ◽

Lewis Acid ◽

Fluorescent Probes ◽

Reaction Mechanisms ◽

Electrostatic Interactions ◽

Design Principles ◽

Covalent Interaction ◽

Environmental Media ◽

Simple Preparation

Small-molecule fluorescent probe with advantages of small size, low background and simple preparation have been widely used. The detection of anions by small-molecule fluorescent probes is usually achieved through one of the following reaction mechanisms: hydrogen bonds and electrostatic interactions; metal or Lewis acid coordination; covalent interaction. This article summarizes the advances in the design principles of small-molecule fluorescent probes for the detection of anions in biological and environmental media in recent years.

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Progress of Small Molecule Fluorescent Probes for Detection of Thiols

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1052.464 ◽

2014 ◽

Vol 1052 ◽

pp. 464-467

Author(s):

Yan Gao

Keyword(s):

Small Molecules ◽

Small Molecule ◽

Fluorescent Probes ◽

Clinical Chemistry ◽

Biological Systems ◽

Quantitative Detection ◽

Antioxidant Systems ◽

Nondestructive Imaging ◽

Sensitivity Specificity

Thiols play key roles in biological systems. They are important parts of many organisms proteins and small molecules, and have an important role in cellular antioxidant systems. In recent years, fluorescent methods for detecting the mercapto compounds have developed rapidly, based on its apparent advantages in sensitivity, specificity and nondestructive imaging. Therefore, the quantitative detection of mercapto biomolecules are very important in biochemical and clinical chemistry. In this review,we summarized the fluorescent probes for thiols according to their unique mechanisms between fluorescent probes and thiols.

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Small-molecule Bifunctional Fluorescent Probes for the Differential Detection of Multiple Guests

Current Organic Synthesis ◽

10.2174/1570179416666190419213812 ◽

2019 ◽

Vol 16 (4) ◽

pp. 485-497 ◽

Cited By ~ 1

Author(s):

Pei-Pei Jia ◽

Shu-Ting Jiang ◽

Lin Xu

Keyword(s):

Real Time ◽

Small Molecule ◽

Fluorescent Probes ◽

Design Principles ◽

Differential Detection ◽

Recent Advances ◽

Multiple Analytes ◽

Real Time Applications

During the last few years, the preparation of bifunctional fluorescent probes, which exhibit dierential response towards multiple analytes, has attracted considerable attention since they are cost-eective and highly desirable for real-time applications. This review focuses on the recent advances in the design principles, recognition mechanisms,and applications of multifunctional fluorescent probes for the differential detection of multiple guests.

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Fluorescent small organic probes for biosensing

Chemical Science ◽

10.1039/d0sc06928k ◽

2021 ◽

Author(s):

Xue Tian ◽

Lloyd C. Murfin ◽

Luling Wu ◽

Simon E. Lewis ◽

Tony D. James

Keyword(s):

Real Time ◽

Small Molecule ◽

Fluorescent Probes ◽

High Selectivity ◽

Signaling Molecules ◽

Living Systems ◽

Time Analysis ◽

Non Invasive ◽

Real Time Analysis

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems.

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Recent advances in 1,8-naphthalimide-based small-molecule fluorescent probes for organelles imaging and tracking in living cells

Coordination Chemistry Reviews ◽

10.1016/j.ccr.2021.214019 ◽

2021 ◽

Vol 444 ◽

pp. 214019

Author(s):

Haitao Yu ◽

Yan Guo ◽

Wencheng Zhu ◽

Kaden Havener ◽

Xujun Zheng

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Living Cells ◽

Recent Advances

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Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

Chemical Society Reviews ◽

10.1039/d0cs00861c ◽

2021 ◽

Vol 50 (2) ◽

pp. 702-734

Author(s):

Luling Wu ◽

Jihong Liu ◽

Ping Li ◽

Bo Tang ◽

Tony D. James

Keyword(s):

Small Molecule ◽

Biological Systems ◽

Two Photon ◽

Small Molecule Probes ◽

Recent Advances ◽

Design Construction

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes.

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