scholarly journals Universal and high-fidelity DNA single nucleotide polymorphism detection based on a CRISPR/Cas12a biochip

2021 ◽  
Vol 12 (12) ◽  
pp. 4455-4462
Author(s):  
Yong Chen ◽  
Yixin Mei ◽  
Xingyu Jiang
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Point Of Care ◽  
High Fidelity ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Crispr System ◽  
Polymorphism Detection ◽  
Genotyping Method ◽  
Short Palindromic Repeat

A universal and high-fidelity genotyping method based on the clustered regularly interspaced short palindromic repeat (CRISPR) system was performed on the microfluidic point-of-care equipment.

scholarly journals Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection

2017 ◽  
Vol 15 (32) ◽  
pp. 6710-6714 ◽  
Author(s):  
Digvijay Gahtory ◽  
Merita Murtola ◽  
Maarten M. J. Smulders ◽  
Tom Wennekes ◽  
Han Zuilhof ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide Polymorphism Detection ◽  
Single Nucleotide ◽  
Polymorphism Detection ◽  
Detection Strategies

In this report, we show how a convenient on-resin copper-click functionalization of azido-functionalized peptide nucleic acids (PNAs) allows various PNA-based detection strategies.

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