Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

2020 ◽  
Vol 8 (21) ◽  
pp. 4620-4626
Author(s):  
Shuiling Jin ◽  
Lanling Weng ◽  
Zhi Li ◽  
Zhenzhen Yang ◽  
Lili Zhu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Biomimetic Mineralization ◽  
Enzyme Cascade ◽  
Metal Organic ◽  
Cancer Tissues

Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.

scholarly journals Nanocomposites for X-Ray Photodynamic Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 4004 ◽  
Author(s):  
Zaira Gadzhimagomedova ◽  
Peter Zolotukhin ◽  
Oleg Kit ◽  
Daria Kirsanova ◽  
Alexander Soldatov
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen ◽  
Modern Medicine ◽  
Oxygen Species ◽  
X Rays ◽  
X Ray ◽  
Metal Organic ◽  
Cancer Tissues

Photodynamic therapy (PDT) has long been known as an effective method for treating surface cancer tissues. Although this technique is widely used in modern medicine, some novel approaches for deep lying tumors have to be developed. Recently, deeper penetration of X-rays into tissues has been implemented, which is now known as X-ray photodynamic therapy (XPDT). The two methods differ in the photon energy used, thus requiring the use of different types of scintillating nanoparticles. These nanoparticles are known to convert the incident energy into the activation energy of a photosensitizer, which leads to the generation of reactive oxygen species. Since not all photosensitizers are found to be suitable for the currently used scintillating nanoparticles, it is necessary to find the most effective biocompatible combination of these two agents. The most successful combinations of nanoparticles for XPDT are presented. Nanomaterials such as metal–organic frameworks having properties of photosensitizers and scintillation nanoparticles are reported to have been used as XPDT agents. The role of metal–organic frameworks for applying XPDT as well as the mechanism underlying the generation of reactive oxygen species are discussed.

scholarly journals Metal–organic frameworks for the generation of reactive oxygen species

2021 ◽  
Vol 2 (4) ◽  
pp. 041301
Author(s):  
Hudson A. Bicalho ◽  
Victor Quezada-Novoa ◽  
Ashlee J. Howarth
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic

π-π Conjugation Promoted Nanocatalysis for Cancer Therapy Based on Covalent Organic Framework

2021 ◽  
Author(s):  
Shuncheng Yao ◽  
Xingru Zhao ◽  
Xingyi Wan ◽  
Xueyu Wang ◽  
Tian Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Oxidative Damage ◽  
Reactive Oxygen ◽  
Ros Production ◽  
Oxygen Species ◽  
Covalent Organic Framework ◽  
Organic Framework

The production of reactive oxygen species (ROS) to elicit lethal cellular oxidative damage is an attractive pathway to kill cancer, but it is still hindered by the low ROS production...

Metal-organic framework-encapsulated nanoparticles for synergetic chemo/chemo-dynamic therapy with targeted H2O2 self-supplying

2021 ◽  
Author(s):  
Ruixue Cui ◽  
Jing Shi ◽  
Zhiliang Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Therapy ◽  
Therapeutic Strategy ◽  
Metal Organic Framework ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dynamic Therapy ◽  
Metal Organic ◽  
Encapsulated Nanoparticles

Nanocatalytic cancer therapy based on chemo-dynamic therapy, which converts hydrogen peroxide (H2O2) into toxic reactive oxygen species via Fenton-like reaction, is regarded as a promising therapeutic strategy due to its...

scholarly journals Superoxide dismutase transcellular shuttle constructed from dendritic MOF and charge reversible protein derivatives

2019 ◽  
Vol 10 (16) ◽  
pp. 4476-4485 ◽  
Author(s):  
Wei Wang ◽  
Sudong Wu ◽  
Jingyun Wang ◽  
Zhen Li ◽  
Hongyan Cui ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Metal Organic

The dendritic metal–organic frameworks facilitate intracellular transportation of charge-reversible superoxide dismutase derivatives for scavenging detrimental reactive oxygen species.

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