Difunctionalized pillar[5]arene-based polymer nanosheets for photodynamic therapy of Staphylococcus aureus infection

Nowadays due to the coronavirus disease 2019 (COVID-19) and to save our lives, we have to use masks in a wider range. Since masks are now considered a protective device to prevent some bacterial or viral diseases, especially COVID-19, and the advice is that we should use them to save our lives and the lives of others. It is true that masks have many benefits, but maybe they are also harmful. It seems that is possible in long- term masking, itself cause side effects or even other diseases. Therefore, since masks are now more widely used, its advantages and even disadvantages are important to us. We think, maybe there are harms that may cause other bacterial diseases as secondary bacterial infection that may be confused with COVID-19 because they may have similar symptoms or may increase the severity of it. In this article, we review Staphylococcus Aureus that may be exacerbate or cause infectious diseases and increase the risk of infection. We may be able to prevent them with some recommendations.

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Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model

Lasers in Surgery and Medicine ◽

10.1002/lsm.20887 ◽

2010 ◽

Vol 42 (1) ◽

pp. 38-44 ◽

Cited By ~ 128

Author(s):

Tianhong Dai ◽

George P. Tegos ◽

Timur Zhiyentayev ◽

Eleftherios Mylonakis ◽

Michael R. Hamblin

Keyword(s):

Staphylococcus Aureus ◽

Photodynamic Therapy ◽

Methicillin Resistant Staphylococcus Aureus ◽

Mouse Skin ◽

Methicillin Resistant ◽

Aureus Infection ◽

Skin Abrasion

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Enzyme activated photodynamic therapy for methicillin-resistant Staphylococcus aureus infection both inv itro and in vivo

Journal of Photochemistry and Photobiology B Biology ◽

10.1016/j.jphotobiol.2014.04.016 ◽

2014 ◽

Vol 136 ◽

pp. 72-80 ◽

Cited By ~ 16

Author(s):

Xiu-Jun Fu ◽

Yun-Qing Zhu ◽

Yin-Bo Peng ◽

You-Shuang Chen ◽

Yi-Ping Hu ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Photodynamic Therapy ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistant ◽

Aureus Infection

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NONINVASIVE OPTICAL IMAGING OF STAPHYLOCOCCUS AUREUS INFECTION IN VIVO USING AN ANTIMICROBIAL PEPTIDE FRAGMENT BASED NEAR-INFRARED FLUORESCENT PROBES

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545813500260 ◽

2013 ◽

Vol 06 (03) ◽

pp. 1350026 ◽

Cited By ~ 9

Author(s):

CUICUI LIU ◽

YUEQING GU

Keyword(s):

Staphylococcus Aureus ◽

Bacterial Infection ◽

Antimicrobial Peptide ◽

Optical Imaging ◽

Bacterial Infections ◽

Near Infrared ◽

Peptide Fragment ◽

Imaging Probe ◽

Aureus Infection

The diagnosis of bacterial infections remains a major challenge in medicine. Optical imaging of bacterial infection in living animals is usually conducted with genetic reporters such as light-emitting enzymes or fluorescent proteins. However, there are many circumstances where genetic reporters are not applicable, and there is an urgent need for exogenous synthetic probes that can selectively target bacteria. Optical imaging of bacteria in vivo is much less developed than methods such as radioimaging and MRI. Furthermore near-infrared (NIR) dyes with emission wavelengths in the region of 650–900 nm can propagate through two or more centimeters of tissue and may enable deeper tissue imaging if sensitive detection techniques are employed. Here we constructed an antimicrobial peptide fragment UBI29-41-based near-infrared fluorescent imaging probe. The probe is composed of UBI29-41 conjugated to a near infrared dye ICG-Der-02. UBI29-41 is a cationic antimicrobial peptide that targets the anionic surfaces of bacterial cells. The probe allows detection of Staphylococcus aureus infection (5 × 107 cells) in a mouse local infection model using whole animal near-infrared fluorescence imaging. Furthermore, we demonstrate that the UBI29-41-based imaging probe can selectively accumulate within bacteria. The significantly higher accumulation in bacterial infection suggests that UBI29-41-based imaging probe may be a promising imaging agent to detect bacterial infections.

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