Traditional and new applications of HCR in biosensing and biomedicine

The Analyst ◽  
2021 ◽  
Author(s):  
Rong Zhou ◽  
Zhuoer Zeng ◽  
Ruowei Sun ◽  
Wenfang Liu ◽  
Qubo Zhu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Double Helix ◽  
Nucleic Acid Amplification ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Single Stranded Dna ◽  
Isothermal Nucleic Acid Amplification ◽  
Hybridization Event ◽  
Nucleic Acid Amplification Technology ◽  
New Applications

Hybridization chain reaction is a very popular isothermal nucleic acid amplification technology. A single-stranded DNA initiator triggers an alternate hybridization event between two hairpins forming a double helix polymer. Due...

scholarly journals Three-dimensional DNA nanostructures to improve the hyperbranched hybridization chain reaction

2019 ◽  
Vol 10 (42) ◽  
pp. 9758-9767 ◽  
Author(s):  
Jing Wang ◽  
Dong-Xia Wang ◽  
Jia-Yi Ma ◽  
Ya-Xin Wang ◽  
De-Ming Kong
Keyword(s):  
Nucleic Acid ◽  
Three Dimensional ◽  
Nucleic Acid Amplification ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Nucleic Acid Amplification Techniques ◽  
Detection Of Biomarkers

Nonenzymatic nucleic acid amplification techniques (e.g. the hybridization chain reaction, HCR) have shown promising potential for amplified detection of biomarkers.

Ultrasensitive detection of microRNAs using catalytic hairpin assembly coupled with enzymatic repairing amplification

2016 ◽  
Vol 52 (93) ◽  
pp. 13584-13587 ◽  
Author(s):  
Chong-Hua Zhang ◽  
Ying Tang ◽  
Ying-Ying Sheng ◽  
Hui Wang ◽  
Zhan Wu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Amplification ◽  
Ultrasensitive Detection ◽  
Isothermal Nucleic Acid Amplification ◽  
Nucleic Acid Amplification Technology ◽  
Catalytic Hairpin Assembly ◽  
Mirna Detection

A novel isothermal nucleic acid amplification technology is developed by coupling CHA with enzymatic repairing amplification for sensitive and selective miRNA detection.

scholarly journals Polymerase chain reaction in microfluidic devices

Lab on a Chip ◽  
2016 ◽  
Vol 16 (20) ◽  
pp. 3866-3884 ◽  
Author(s):  
Christian D. Ahrberg ◽  
Andreas Manz ◽  
Bong Geun Chung
Keyword(s):  
Polymerase Chain Reaction ◽  
Nucleic Acid ◽  
Microfluidic Devices ◽  
Digital Pcr ◽  
Nucleic Acid Amplification ◽  
Chain Reaction ◽  
Space Domain ◽  
Isothermal Nucleic Acid Amplification ◽  
Time Space ◽  
Polymerase Chain

Developments of microfluidic-based time/space domain PCR, digital PCR, and isothermal nucleic acid amplification.

Silver nanocluster-lightened hybridization chain reaction

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57502-57506 ◽  
Author(s):  
Lin Liu ◽  
Qing Li ◽  
Li-Juan Tang ◽  
Ru-Qin Yu ◽  
Jian-Hui Jiang
Keyword(s):  
Nucleic Acid ◽  
Silver Nanoclusters ◽  
Hybridization Chain Reaction ◽  
Label Free ◽  
Chain Reaction ◽  
Silver Nanocluster ◽  
Turn On ◽  
Nucleic Acid Assays

A hybridization chain reaction (HCR) lightened by DNA-stabilized silver nanoclusters (AgNCs) as a label-free and turn on fluorescence platform for nucleic acid assays.

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