An Ion Transport Switch Based on Light-Responsive Conformation-Dependent G-Quadruplex Transmembrane Channels

2021 ◽  
Author(s):  
Chunying Li ◽  
Hui Chen ◽  
Xiaohai Yang ◽  
Kemin Wang ◽  
Jianbo Liu
Keyword(s):  
Ion Transport ◽  
Selective Transport ◽  
G Quadruplex ◽  
Transmembrane Channels

A light-responsive ion transport switch has been developed based on conformation-dependent azobenzene-incorporated lipophilic G-quadruplex channels, which provides a new smart approach for the selective transport of K+ ions across the...

Artificial Transmembrane Channels for Sodium and Potassium

2002 ◽  
Vol 85 (3) ◽  
pp. 219-241 ◽  
Author(s):  
Peter J. Cragg
Keyword(s):  
Ion Transport ◽  
Alkali Metals ◽  
Structural Features ◽  
Artificial System ◽  
Ion Specificity ◽  
Ion Concentrations ◽  
Transmembrane Channels ◽  
Essential Function ◽  
Membrane Spanning ◽  
Sodium And Potassium

Transport of alkali metals, particularly sodium and potassium, across cell membranes is an essential function performed by special proteins that enable cells to regulate inter- and extracellular ion concentrations with exceptional selectivity. The importance of these channel-forming proteins has led to researchers emulating of their structural features: an ion-specific filter and conduction at rates up to 108 ions per second. Synthetic helical and cyclic polypeptides form channels, however, the specificity of ion transport is often low. Ion-specific macrocycles have been used as filters from which membrane-spanning derivatives have been prepared. Success has been limited as many compounds act as ion carriers rather than forming transmembrane channels. Surfactant compounds also allow ions to cross membranes but any specificity is serendipitous. Overall it seems possible to mimic either ion specificity or efficient transmembrane ion transport. The goal for the future will be to combine both characteristics in one artificial system.

Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport

2019 ◽  
Vol 55 (80) ◽  
pp. 12004-12007 ◽  
Author(s):  
Chunying Li ◽  
Hui Chen ◽  
Li Zhou ◽  
Hui Shi ◽  
Xiaoxiao He ◽  
...  
Keyword(s):  
Ion Channel ◽  
Potassium Transport ◽  
Single Stranded Dna ◽  
G Quadruplex ◽  
Transmembrane Channels

G-quadruplex single-stranded DNA was modified lipophilically and developed as a biomimetic ion channel for selective and switchable K+ transport.

scholarly journals Selective Transport of Silver(I) Ion Through Polymer Membranes Containing Thioether Donor Macrocycles as Carriers

2008 ◽  
Vol 5 (2) ◽  
pp. 271-274 ◽  
Author(s):  
A. Nezhadali ◽  
M. Akbarpour
Keyword(s):  
Aqueous Solution ◽  
Ion Transport ◽  
Sulfur Atom ◽  
Polymer Membranes ◽  
Polymer Membrane ◽  
Transport Rate ◽  
Transport Efficiency ◽  
Selective Transport ◽  
Source Phase ◽  
Better Than

The Preparation of polymer membrane and it's selectivity to silver(I) ion from an aqueous solution containing seven metal cations, Co(II), Ni(II), Cu(II), Zn(II), Ag(I), Cd(II) and Pb(II), was studied. The source phase contained equimolar concentrations of the above mentioned cations with the source and receiving phases being buffered at pH 5.0 and 3.0 respectively. The effect of variation in the number of the macrocyclic sulfur atom donor set anssd the size of ring 9 and 16 member macrocycles on transport efficiency is presented. Silver(I) ion transport occurred (at 25°C) from the aqueous source phase across the polymer membrane (derived from cellulos triacetate) containing ligands 9-membered, S3-donor and16-membered S4-donor macrocycles as the ionophors in separate experiments into the aqueous receiving phase. Clear transport selectivity for silver(I) ion was observed using both thioether donor macrocycles. The efficiency of transport rate for silver(I) ion with using 9-membered S3-donor macrocycle as carrier was better than 16-membered S4-donor .

Unimolecular artificial transmembrane channels showing reversible ligand-gating behavior

2021 ◽  
Author(s):  
Qi Xiao ◽  
Wei-Wei Haoyang ◽  
Tao Lin ◽  
Zhan-Ting Li ◽  
Dan-Wei Zhang ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Lipid Bilayers ◽  
Intramolecular Hydrogen Bonds ◽  
Selective Transport ◽  
Ligand Gating ◽  
Transmembrane Channels ◽  
Intramolecular Hydrogen

A series of peptide-appended bisresorcinarenes were synthesized, which adopted tubular conformation induced by intramolecular hydrogen bonds. The derivatives formed unimolecular artificial transmembrane channels in lipid bilayers to enable selective transport...

Umbrella sampling molecular dynamics simulations reveal concerted ion movement through G-quadruplex DNA channels

2017 ◽  
Vol 19 (18) ◽  
pp. 11017-11025 ◽  
Author(s):  
Parisa Akhshi ◽  
Gang Wu
Keyword(s):  
Molecular Dynamics ◽  
Ion Transport ◽  
Molecular Dynamics Simulations ◽  
Md Simulations ◽  
Umbrella Sampling ◽  
Potential Of Mean Force ◽  
Quadruplex Dna ◽  
Ion Movement ◽  
G Quadruplex ◽  
Dynamics Simulations

We have applied the umbrella sampling (US) method in all-atom molecular dynamics (MD) simulations to obtain potential of mean force (PMF) profiles for ion transport through three representative G-quadruplex DNA channels: [d(TG4T)]4, [d(G3T4G4)]2, and d[G4(T4G4)3].

Characterization of acetylcholine-induced ion transport in human duodenum

2001 ◽  
Vol 120 (5) ◽  
pp. A532-A532
Author(s):  
R LARSEN ◽  
M HANSEN ◽  
N BINSLEV ◽  
A MERTZNIELSEN
Keyword(s):  
Ion Transport
Sign in / Sign up

Export Citation Format

Share Document