ROS activated prodrug for ALDH overexpressed cancer stem cells

2021 ◽  
Author(s):  
Miae Won ◽  
Ji Hyeon Kim ◽  
Myung Sun Ji ◽  
Jong Seung Kim
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Cell Population ◽  
Stem Cell Population ◽  
Cancer Stem Cell Population

We developed a prodrug (DE-CPT) that efficiently decreases the cancer stem cell population and kills the cancer cells by ROS activation.

scholarly journals MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells

2011 ◽  
Vol 4 (1) ◽  
pp. 7 ◽  
Author(s):  
Moorthy P Ponnusamy ◽  
Parthasarathy Seshacharyulu ◽  
ArokiaPriyanka Vaz ◽  
Parama Dey ◽  
Surinder K Batra
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Cell Population ◽  
Stem Cell Population ◽  
Ovarian Cancer Cells ◽  
Her2 Expression ◽  
Cancer Stem Cell Population

scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

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