Tomatoes consumed in-season prevents oxidative stress in Fischer 344 rats: impact of geographical origin

2021 ◽  
Author(s):  
Álvaro Javier Cruz Carrión ◽  
Maria Josefina Ruiz de Azua ◽  
Francisca Isabel Isabel Bravo ◽  
Gerard Aragonès ◽  
Begoña Muguerza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lycopersicon Esculentum ◽  
Geographical Origin ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Health Promoting

Tomato (Lycopersicon esculentum Mill.) constitutes an important source of health-promoting compounds including bioactive antioxidants, such as flavonoids, that can differ in terms of composition and quantity depending on the conditions...

Effect of diquat-induced oxidative stress on iron metabolism in male Fischer-344 rats

BioMetals ◽  
2011 ◽  
Vol 24 (6) ◽  
pp. 1123-1131 ◽  
Author(s):  
Masashi Higuchi ◽  
Yasunaga Yoshikawa ◽  
Koichi Orino ◽  
Kiyotaka Watanabe
Keyword(s):  
Oxidative Stress ◽  
Iron Metabolism ◽  
Fischer 344 Rats ◽  
Fischer 344

Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F2-isoprostanes and F4-neuroprostanes

2003 ◽  
Vol 34 (12) ◽  
pp. 1631-1635 ◽  
Author(s):  
Jihan A Youssef ◽  
Linda S Birnbaum ◽  
Larry L Swift ◽  
Jason D Morrow ◽  
Mostafa Z Badr
Keyword(s):  
Oxidative Stress ◽  
Gray Matter ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Brain Levels ◽  
Age Independent

Captopril as an antioxidant in lead-exposed Fischer 344 rats

1999 ◽  
Vol 18 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Hande Gurer ◽  
Rachel Neal ◽  
Ping Yang ◽  
Serdar Oztezcan ◽  
Nuran Ercal
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Converting Enzyme ◽  
Catalase Activity ◽  
Antihypertensive Agent ◽  
Enzyme Inhibitor ◽  
Antioxidant Effect ◽  
Converting Enzyme ◽  
Fischer 344 Rats ◽  
Glutathione Disulfide ◽  
Fischer 344

1 Recent studies suggest that lead induces oxidative stress in various tissues. 2 Captopril ([2S]-1-[3-mercapto-2-methylpropionyl]-L-proline), an angiotensin-converting enzyme inhibitor, is a well-known antihypertensive agent and is also believed to function as an antioxidant. 3 In the present study the antioxidant effect of captopril on lead-induced oxidative stress was studied in Fischer 344 rats. Their liver, brain and kidneys were assayed for glutathione (GSH), glutathione disulfide (GSSG), malondialdehyde concentrations, and catalase activities. The results from animals treated with captopril were compared to results of control and lead-exposed non-treated groups. 4 The captopril-treated samples showed higher GSH:GSSG ratios in the liver, brain and kidneys, as well as slightly decreased malondialdehyde concentrations. The catalase activity was not significantly affected.

scholarly journals The role of biotransformation and oxidative stress in 3,5-dichloroaniline (3,5-DCA) induced nephrotoxicity in isolated renal cortical cells from male Fischer 344 rats

Toxicology ◽  
2016 ◽  
Vol 341-343 ◽  
pp. 47-55 ◽  
Author(s):  
Christopher R. Racine ◽  
Travis Ferguson ◽  
Debbie Preston ◽  
Dakota Ward ◽  
John Ball ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fischer 344 Rats ◽  
Cortical Cells ◽  
Fischer 344 ◽  
And Oxidative Stress

Breath ethane as a marker of reactive oxygen species during manipulation of diet and oxygen tension in rats

1999 ◽  
Vol 86 (2) ◽  
pp. 617-622 ◽  
Author(s):  
Terence H. Risby ◽  
Long Jiang ◽  
Sigfried Stoll ◽  
Donald Ingram ◽  
Edward Spangler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Metabolic Rate ◽  
Oxygen Tension ◽  
Gas Mixture ◽  
Oxygen Species ◽  
Fischer 344 Rats ◽  
Gas Sampling ◽  
Fischer 344 ◽  
Ad Libitum

Breath ethane, O2consumption, and CO2 production were analyzed in 24-mo-old female Fischer 344 rats that had been fed continuously ad libitum (AL) or restricted 30% of AL level (DR) diets since 6 wk of age. Rats were placed in a glass chamber that was first flushed with air, then with a gas mixture containing 12% O2. After equilibration, a sample of the outflow was collected in gas sampling bags for subsequent analyses of ethane and CO2. The O2 and CO2 levels were also directly monitored in the outflow of the chamber. O2 consumption and CO2 production increased for DR rats. Hypoxia decreased O2consumption and CO2 production for the AL-fed and DR rats. These changes reflect changes in metabolic rate due to diet and [Formula: see text]. A significant decrease in ethane generation was found in DR rats compared with AL-fed rats. Under normoxic conditions, breath ethane decreased from 2.20 to 1.61 pmol ethane/ml CO2. During hypoxia the levels of ethane generation increased, resulting in a DR-associated decrease in ethane from 2.60 to 1.90 pmol ethane/ml CO2. These results support the hypothesis that DR reduces the level of oxidative stress.

Toxic effects of inhaled DMMP on the kidneys of Fischer-344 rats

1987 ◽  
Vol 45 ◽  
pp. 880-881
Author(s):  
D.R. Mattie ◽  
C.J. Hixson
Keyword(s):  
Left Kidney ◽  
Inhalation Exposure ◽  
Electron Microscopic Examination ◽  
Exposure Period ◽  
Male Rats ◽  
Continuous Exposure ◽  
Fischer 344 Rats ◽  
Electron Microscopic ◽  
Thin Sections ◽  
Fischer 344

Dimethylmethylphosphonate (DMMP) is a simple organophosphate used industrially as a flame retardant and to lower viscosity in polyester and epoxy resins. The military considered the use of DMMP as a nerve gas simulant. Since military use of DMMP involved exposure by inhalation, there was a need for a subchronic inhalation exposure to DMMP to fully investigate its toxic potential.Male Fischer-344 rats were exposed to 25 ppm or 250 ppm DMMP vapor on a continuous basis for 90 days. An equal number of control rats were sham-exposed. Following the 90-day continuous exposure period, 15 male rats were sacrificed from each group. Two rats from each group had the left kidney perfused for electron microscopic examination. The kidneys were perfused from a height of 150 cm water with 1% glutaraldehyde in Sorensen's 0.1M phosphate buffer pH 7.2. An additional kidney was taken from a rat in each group and fixed by immersion in 2.5% glutaraldehyde and 2% paraformaldehyde in 0.1M cacodylate buffer pH 7.4. A portion of the 9 kidneys collected for electron microscopy were processed into Epon 812. Thin sections, stained with uranyl acetate and lead citrate, were examined with a JEOL 100B Transmission Electron Microscope. Microvilli height was measured on photographs of the cells of proximal tubules. This data, along with morphologic features of the cells, allows the proximal convoluted tubules (PCT) to be identified as being S1, S2, or S3 segment PCT.

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