Analysis of the effects of aryl hydrocarbon receptor expression on cancer cell invasion via three-dimensional microfluidic invasion assays

Lab on a Chip ◽  
2022 ◽  
Author(s):  
Bingyu B. Li ◽  
Erica Y. Scott ◽  
Ninni E. Olafsen ◽  
Jason Matthews ◽  
Aaron R. Wheeler
Keyword(s):  
Cell Invasion ◽  
Three Dimensional ◽  
Transcriptome Profiling ◽  
Receptor Expression ◽  
Unique Combination ◽  
Cancer Cell Invasion ◽  
Aryl Hydrocarbon ◽  
Functional Discrimination ◽  
Digital Microfluidic ◽  
Invasion Assays

We studied the effect of AHR expression on metastasis using cell invasion in digital microfluidic microgel systems (CIMMS), which provided a unique combination of functional discrimination with transcriptome profiling of sub-populations of cells.

Digital microfluidics for spheroid-based invasion assays

Lab on a Chip ◽  
2016 ◽  
Vol 16 (8) ◽  
pp. 1505-1513 ◽  
Author(s):  
Brian F. Bender ◽  
Andrew. P. Aijian ◽  
Robin. L. Garrell
Keyword(s):  
Drug Discovery ◽  
Cell Invasion ◽  
Cell Biology ◽  
Digital Microfluidics ◽  
Three Dimensional ◽  
Multicellular Spheroids ◽  
Microfluidic Platform ◽  
Digital Microfluidic ◽  
Biology Research ◽  
Invasion Assays

A digital microfluidic platform that enables the formation, gel encapsulation, and assaying of three-dimensional multicellular spheroids is described. Such a platform can facilitate automation of cell invasion assays for cell biology research and drug discovery.

Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions

Lab on a Chip ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 1378-1387 ◽  
Author(s):  
Manami Sugimoto ◽  
Yoichi Kitagawa ◽  
Masumi Yamada ◽  
Yuya Yajima ◽  
Rie Utoh ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Quantitative Evaluation ◽  
Cell Invasion ◽  
Three Dimensional ◽  
Composite Hydrogel ◽  
Cancer Cell Invasion ◽  
New System

A new system for quantitatively evaluating cancer cell invasion in a three-dimensional environment was developed using composite hydrogel microfibers having a micropassage.

Microfluidic Device Fabricated by Three-Dimensional Lithography for Observation of Cancer Cell Invasion Process

2018 ◽  
Vol 138 (9) ◽  
pp. 435-440
Author(s):  
Saeko Tachikawa ◽  
Shohei Kaneda ◽  
Momoko Kumemura ◽  
Rui Sato ◽  
Takuya Tsukamoto ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Microfluidic Device ◽  
Cell Invasion ◽  
Three Dimensional ◽  
Invasion Process ◽  
Cancer Cell Invasion
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