Laser capture microdissection-capillary zone electrophoresis-tandem mass spectrometry (LCM-CZE-MS/MS) for spatially resolved top-down proteomics: a pilot study of zebrafish brain

2022 ◽  
Author(s):  
Rachele A Lubeckyj ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Pilot Study ◽  
Tandem Mass ◽  
Biological Functions ◽  
Top Down ◽  
Zebrafish Brain ◽  
Spatially Resolved ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
Laser Capture

Mass spectrometry (MS)-based spatially resolved top-down proteomics (TDP) of tissues is crucial for understanding the roles played by microenvironmental heterogeneity in the biological functions of organs and for discovering new...

scholarly journals Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry

10.3791/58644 ◽  
2018 ◽  
Author(s):  
Elijah N. McCool ◽  
Rachele Lubeckyj ◽  
Xiaojing Shen ◽  
Qiang Kou ◽  
Xiaowen Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Capillary Zone Electrophoresis ◽  
Large Scale ◽  
Tandem Mass ◽  
Top Down ◽  
Zone Electrophoresis ◽  
Capillary Zone

scholarly journals Capillary zone electrophoresis-tandem mass spectrometry for top-down proteomics using attapulgite nanoparticles functionalized separation capillaries

Talanta ◽  
2019 ◽  
Vol 202 ◽  
pp. 165-170 ◽  
Author(s):  
Tingting Wang ◽  
Daoyang Chen ◽  
Rachele A. Lubeckyj ◽  
Xiaojing Shen ◽  
Zhichang Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Capillary Zone Electrophoresis ◽  
Tandem Mass ◽  
Top Down ◽  
Zone Electrophoresis ◽  
Capillary Zone

scholarly journals Capillary Zone Electrophoresis-Top-Down Tandem Mass Spectrometry for In-Depth Characterization of Hemoglobin Proteoforms in Clinical and Veterinary Samples

2020 ◽  
Vol 92 (15) ◽  
pp. 10531-10539
Author(s):  
Alexander Stolz ◽  
Ylva Hedeland ◽  
Liesa Salzer ◽  
Jennifer Römer ◽  
Reidun Heiene ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Capillary Zone Electrophoresis ◽  
Tandem Mass ◽  
Top Down ◽  
Zone Electrophoresis ◽  
Capillary Zone
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