Ammonium Iodide-Catalyzed Radical-mediated Tandem Cyclization of Aromatic Aldehydes, Arylamines and 1,4-Dioxane

2021 ◽  
Author(s):  
Yunfeng Liao ◽  
Yiyan Yan ◽  
Hongrui Qi ◽  
Weijie Zhang ◽  
Yanjun Xie ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Ammonium Iodide ◽  
Novel Approach ◽  
Tandem Cyclization ◽  
Three Components

We have developed a novel approach for the construction of 2-((2-arylquinolin-4-yl)oxy)ethan-1-ol derivatives by an NH4I-catalyzed radical-mediated tandem cyclization of three components including aromatic aldehydes, arylamines and 1,4-Dioxane. This strategy involves...

Base-promoted aerobic oxidative synthesis of fused 1,3,5-triazines under metal-free conditions

2020 ◽  
Vol 22 (20) ◽  
pp. 6778-6782
Author(s):  
Jinjin Chen ◽  
Zhaozhao Sun ◽  
Fuhong Xiao ◽  
Guo-Jun Deng
Keyword(s):  
Aerobic Oxidation ◽  
Aromatic Aldehydes ◽  
Ammonium Iodide ◽  
Metal Free

An efficient base-promoted aerobic oxidation procedure for the synthesis of fused 1,3,5-triazines from 2-aminobenzimidazoles, aromatic aldehydes, and ammonium iodide under metal-free conditions has been developed.

Sequential Cobalt/Rhodium‐Catalyzed Tandem Cyclization of Aromatic Aldehydes with Acrylates for Preparing 3‐Substituted Phthalides in Oxygen Atmosphere and Neat Water

2021 ◽  
Author(s):  
Xin‐Ran Li ◽  
Wan‐Di Li ◽  
Wen‐Ting Wei ◽  
Juan Fan ◽  
Zhong‐Wen Liu ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Oxygen Atmosphere ◽  
Neat Water ◽  
Tandem Cyclization

scholarly journals Synthesis of Symmetrical and Asymmetrical Azines Encompassing Naphtho[2,1-b]furan by a Novel Approach

2011 ◽  
Vol 8 (1) ◽  
pp. 354-360 ◽  
Author(s):  
K. Veena ◽  
M. Ramaiah ◽  
G. K. Vanita ◽  
T. S. Avinash ◽  
V. P. Vaidya
Keyword(s):  
Antibacterial Activity ◽  
Aspergillus Parasiticus ◽  
Second Harmonic ◽  
Aromatic Aldehydes ◽  
Single Step ◽  
Spectral Studies ◽  
Reaction Conditions ◽  
Novel Approach ◽  
Bacillus Subtilus ◽  
Shg Efficiency

The starting material 3-nitro-2-acetylnaphtho[2,1-b]furan (2) was obtained by nitration of 2-acetylnaphtho[2,1-b] furan (1), under mild condition. The compound 1 was synthesized by the reaction of 2-hydroxy-1-naphthaldehyde with chloroacetone, where in both condensation and cyclization took place in single step. The reaction of 3-nitro-2-acetylnaphtho[2,1-b]furan (2) with hydrazine hydrate produced corresponding hydrazone (3) in excellent yield, which on treatment with various aromatic aldehydes under different reaction conditions resulted in the formation of symmetrical azines (4a-e) and unsymmetrical azines (5a-e). All the newly synthesized compounds have been characterized by analytical and spectral studies and were screened for antibacterial antibacterial activity againstBacillus subtilusandAlcaligenes fecaliesand antifungal activity againstAspergillus nidulans, Aspergillus parasiticusandAspergillus terrus. The Second Harmonic Generation (SHG) efficiency of some of the synthesized compounds was measured by powder technique using Nd:YAG laser.

Open-Air Dual-Diamination of Aromatic Aldehydes: Direct Synthesis of Azolo-Fused 1,3,5-Triazines Facilitated by Ammonium Iodide

2021 ◽  
Author(s):  
Qinghe Gao ◽  
Manman Wu ◽  
Le Zhang ◽  
Pengju Xu ◽  
He Wang ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Aromatic Aldehydes ◽  
Ammonium Iodide

Four-component quinazoline synthesis from simple anilines, aromatic aldehydes and ammonium iodide under metal-free conditions

2018 ◽  
Vol 20 (24) ◽  
pp. 5459-5463 ◽  
Author(s):  
Jinjin Chen ◽  
Dan Chang ◽  
Fuhong Xiao ◽  
Guo-Jun Deng
Keyword(s):  
Aromatic Aldehydes ◽  
Ammonium Iodide ◽  
Metal Free ◽  
Quinazoline Derivatives

Substituted quinazoline derivatives were selectively prepared from anilines, aromatic aldehydes and NH4I under metal-free conditions.

An efficient Sn(ii)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework

2017 ◽  
Vol 15 (11) ◽  
pp. 2385-2391 ◽  
Author(s):  
Santosh S. Chavan ◽  
Mrudul V. Supekar ◽  
Pralhad A. Burate ◽  
Bapurao D. Rupanwar ◽  
Anil M. Shelke ◽  
...  
Keyword(s):  
Ethyl Cyanoacetate ◽  
Aromatic Aldehydes ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Tandem Cyclization

A novel Sn(ii)-catalyzed tandem cyclization reaction of aromatic aldehydes with ethyl cyanoacetate has been achieved to afford a series of 3-substituted azetidine-2,4-diones in good to excellent yields.

Diffusion Across International Organizations: Connectivity and Convergence

2018 ◽  
Vol 73 (02) ◽  
pp. 399-433 ◽  
Author(s):  
Thomas Sommerer ◽  
Jonas Tallberg
Keyword(s):  
Spatial Analysis ◽  
International Organizations ◽  
Participatory Governance ◽  
General Study ◽  
Novel Approach ◽  
Governance Arrangements ◽  
Methodological Strategy ◽  
Three Components

AbstractWhile extensive research shows that policies and institutions spread across states through processes of diffusion, we know little about diffusion among international organizations (IOs). We develop a novel approach for the study of diffusion among IOs. This approach consists of three components: a theoretical focus on connectivity among IOs as pathways for diffusion; a conceptual differentiation between alternative types of convergence effects; and a methodological strategy combining dyadic and spatial analysis of diffusion. We illustrate the usefulness of this approach through an empirical case: the diffusion of participatory governance arrangements among IOs from 1970 to 2010. The analysis shows that connectivity among IOs contributes to convergence, which typically is manifested through imitation of very specific institutional models. The article's findings have implications both for the study of IOs and for the general study of diffusion.

The Jovian ring

1984 ◽  
Vol 75 ◽  
pp. 203-209
Author(s):  
Joseph A. Burns
Keyword(s):  
Equatorial Plane ◽  
Charged Particles ◽  
Dynamical Evolution ◽  
Main Band ◽  
Small Grains ◽  
Three Components

ABSTRACTLying in Jupiter's equatorial plane is a diaphanous ring having little substructure within its three components (main band, faint disk, and halo). Micron-sized grains account for much of the visible ring, but particles of centimeter sizes and larger must also be present to absorb charged particles. Since dynamical evolution times and survival life times are quite short (≲102-3yr) for small grains, the Jovian ring is being continually replenished; probably most of the visible ring is generated by micrometeoroids colliding into unseen parent bodies that reside in the main band.

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

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