Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy

2022 ◽  
Author(s):  
Huiling Dong ◽  
Yanan Gao ◽  
Xuefei Huang ◽  
Xuanjun Wu
Keyword(s):  
Sialic Acid ◽  
Global Health ◽  
Indocyanine Green ◽  
Health Problem ◽  
Near Infrared ◽  
Next Generation ◽  
Continuous Action ◽  
Near Infrared Dye ◽  
Cancer Theranostics ◽  
Global Health Problem

Cancer is a multifaceted global health problem that requires continuous action to develop next-generation cancer theranostics. Inspired by the emerging use of indocyanine green (ICG), the only clinical approved near-infrared...

scholarly journals Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

Metallomics ◽  
2021 ◽  
Vol 13 (4) ◽  
Author(s):  
James P C Coverdale ◽  
Collette S Guy ◽  
Hannah E Bridgewater ◽  
Russell J Needham ◽  
Elizabeth Fullam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Global Health ◽  
Mechanism Of Action ◽  
Health Problem ◽  
Normal Lung ◽  
Lung Cells ◽  
Redox Mechanism ◽  
Human Lung Cells ◽  
Half Sandwich ◽  
Global Health Problem

Abstract The treatment of tuberculosis (TB) poses a major challenge as frontline therapeutic agents become increasingly ineffective with the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). To combat this global health problem, new antitubercular agents with novel modes of action are needed. We have screened a close family of 17 organometallic half-sandwich Os(II) complexes [(arene)Os(phenyl-azo/imino-pyridine)(Cl/I)]+Y– containing various arenes (p-cymene, biphenyl, or terphenyl), and NMe2, F, Cl, or Br phenyl or pyridyl substituents, for activity towards Mtb in comparison with normal human lung cells (MRC5). In general, complexes with a monodentate iodido ligand were more potent than chlorido complexes, and the five most potent iodido complexes (MIC 1.25–2.5 µM) have an electron-donating Me2N or OH substituent on the phenyl ring. As expected, the counter anion Y (PF6–, Cl–, I–) had little effect on the activity. The pattern of potency of the complexes towards Mtb is similar to that towards human cells, perhaps because in both cases intracellular thiols are likely to be involved in their activation and their redox mechanism of action. The most active complex against Mtb is the p-cymene Os(II) NMe2-phenyl-azopyridine iodido complex (2), a relatively inert complex that also exhibits potent activity towards cancer cells. The uptake of Os from complex 2 by Mtb is rapid and peaks after 6 h, with temperature-dependence studies suggesting a major role for active transport. Significance to Metallomics Antimicrobial resistance is a global health problem. New advances are urgently needed in the discovery of new antibiotics with novel mechanisms of action. Half-sandwich organometallic complexes offer a versatile platform for drug design. We show that with an appropriate choice of the arene, an N,N-chelated ligand, and monodentate ligand, half-sandwich organo–osmium(II) complexes can exhibit potent activity towards Mycobacterium tuberculosis (Mtb), the leading cause of death from a single infectious agent. The patterns of activity of the 17 azo- and imino-pyridine complexes studied here towards Mtb and normal lung cells suggest a common redox mechanism of action involving intracellular thiols.

Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

2021 ◽  
Vol 141 ◽  
pp. 243-254
Author(s):  
Sila Ozlem Sener ◽  
Ufuk Ozgen ◽  
Seyda Kanbolat ◽  
Nuriye Korkmaz ◽  
Merve Badem ◽  
...  
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Therapeutic Potential ◽  
Global Health Problem

scholarly journals Toxicity of Botanical Medicines: An Overlooked Global Health Problem

2016 ◽  
Vol 106 (1) ◽  
pp. 16-17 ◽  
Author(s):  
Donald M. Marcus ◽  
Arthur P. Grollman
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Botanical Medicines ◽  
Global Health Problem

scholarly journals Victimization of persons with severe mental illness: a pressing global health problem

2017 ◽  
Vol 16 (1) ◽  
pp. 26-27 ◽  
Author(s):  
Marvin S. Swartz ◽  
Sayanti Bhattacharya
Keyword(s):  
Mental Illness ◽  
Global Health ◽  
Severe Mental Illness ◽  
Health Problem ◽  
Global Health Problem

scholarly journals Decriminalisation of gender-based violence is a global health problem

2017 ◽  
Vol 2 (3) ◽  
pp. e000438 ◽  
Author(s):  
Jenevieve Mannell ◽  
Sarah Hawkes
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Gender Based Violence ◽  
Gender Based ◽  
Global Health Problem

scholarly journals CS2 ECONOMIC BURDEN OF WORK LOSS AMONG SUFFERERS OF LYMPHATIC FILARIASIS: AN ERADICABLE GLOBAL HEALTH PROBLEM

2006 ◽  
Vol 9 (3) ◽  
pp. A2-A3 ◽  
Author(s):  
M Singh ◽  
LT Pizzi ◽  
JH Lofland ◽  
MK Higashi ◽  
NM Patel
Keyword(s):  
Global Health ◽  
Lymphatic Filariasis ◽  
Health Problem ◽  
Economic Burden ◽  
Work Loss ◽  
Global Health Problem
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