The introduction of the C-22–C-23 ethylenic linkage in ergosterol biosynthesis
Keyword(s):
C 23
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Methods for the chemical synthesis of [23−3H2]lanosterol, [23,25−3H3]24-methyldihydrolanosterol and [24,28−3H2]24-methyldihydrolanosterol are described. It is shown that, in the biosynthesis of ergosterol from [26,27−14C2,23−3H2]lanosterol by the whole cells of Saccharomyces cerevisiae, one of the original C-23 hydrogen atoms is lost and the other is retained at C-23 of ergosterol. It is also shown that 24-methyldihydrolanosterol is converted into ergosterol in good yield and without prior conversion into a 24-methylene derivative. On the basis of these results possible pathways for the formation of the ergosterol side chain from a 24-methylene side chain are discussed.
1996 ◽
Vol 40
(2)
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pp. 443-447
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Keyword(s):
2004 ◽
Vol 70
(7)
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pp. 4053-4063
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2019 ◽
2019 ◽
Keyword(s):
1994 ◽
Vol 59
(6)
◽
pp. 1439-1450
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Keyword(s):
Keyword(s):