scholarly journals Fatty acid synthetase activity in the liver and adipose tissue of rats fed with various carbohydrates

1972 ◽  
Vol 129 (2) ◽  
pp. 439-446 ◽  
Author(s):  
K. R. Bruckdorfer ◽  
I. H. Khan ◽  
John Yudkin
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Plasma Insulin ◽  
Fatty Acid Synthetase ◽  
Plasma Triglyceride ◽  
Insulin Concentration ◽  
Synthetase Activity ◽  
Plasma Insulin Concentration ◽  
Plasma Triglyceride Concentration ◽  
Fatty Acid Synthetase Activity

1. The inclusion of sucrose in the diet of rats led to an increase in hepatic fatty acid synthetase activity compared with that of rats fed with starch as the sole carbohydrate. The higher activity occurred within 18h of the introduction of sucrose and persisted with fluctuations for the 30 days of the experiment. Reversal of the diets in some rats after 21 days led to changes in the enzyme activity to values appropriate to the second diet. The plasma triglyceride concentration followed a similar pattern. 2. A comparison of the effects of diets with starch, glucose, maltose, sucrose or fructose showed that fructose gave the highest values of triglyceride content and of fatty acid synthetase activity in liver, but the lowest values of the synthetase activity in adipose tissue and the lowest values of plasma insulin concentration. These effects may perhaps be attributed to the low insulin response to fructose and to the high affinity of the liver for this sugar. 3. When the diet contained fructose or sucrose there was a correlation between hepatic synthetase activity and plasma triglyceride concentration. Neither of these, however, was related to plasma insulin concentration. On the other hand, there was a correlation between plasma insulin concentration and fatty acid synthetase activity in adipose tissue. 4. When rats were starved and then re-fed the differences in enzyme activities induced by fructose or glucose were minimized. This, together with the varying degree of difference during the course of the experiments, may explain why other workers, using the starvation–re-feeding technique and making measurements on one day only, have failed to observe differences in the activities of lipogenic enzymes in animals fed with either fructose or glucose.

scholarly journals Development of fatty acid-synthetic capacity in interscapular brown adipose tissue during suckling in genetically obese Zucker rats

1983 ◽  
Vol 216 (3) ◽  
pp. 543-549 ◽  
Author(s):  
R Bazin ◽  
M Lavau ◽  
C Guichard
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Brown Adipose Tissue ◽  
Fatty Acid Synthetase ◽  
Fat Deposition ◽  
Synthetase Activity ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Fatty Acid Synthetase Activity

The development of the lipogenic capacity in brown adipose tissue was studied in suckling lean (Fa/fa) and obese (fa/fa) Zucker pups aged from 7 to 22 days. In both lean and obese pups, activities of the two key lipogenic enzymes, fatty acid synthetase and acetyl-CoA carboxylase, and of citrate cleavage enzyme rose from the early to the late suckling period. Compared with lean pups, 7-day-old fa/fa pups showed a 35% increase in fat accumulation in interscapular brown adipose tissue and a 25% increase in fatty acid synthetase activity. By 10 days of age, fat deposition, lipogenesis in vivo (assessed by the incorporation of 3H from 3H2O into fatty acids) and fatty acid synthetase activity were 1.5-2-fold higher in pre-obese than in lean pups. Compared with lean pups, the increased lipogenesis in vivo observed in brown adipose tissue of 10-day-old pre-obese pups could not entirely account for the difference in fat deposition observed in this tissue, suggesting that additional mechanisms are at play to explain the increased fat content of this tissue.

scholarly journals 146 Nutritional Advances in Fetal and neonatal development: effect of fatty acid supplementation

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 121-122
Author(s):  
Alejandro E Relling
Keyword(s):  
Small Intestine ◽  
Fatty Acid ◽  
Plasma Insulin ◽  
Linear Increase ◽  
Late Gestation ◽  
Insulin Concentration ◽  
Plasma Insulin Concentration ◽  
Pufa Supplementation ◽  
Epa And Dha ◽  
Offspring Growth

Abstract Data from a series of experiments demonstrates that maternal supply of polyunsaturated fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), during late gestation affects offspring growth. The increase in growth is independent on the fatty acid supplemented during the growing or finishing phase of the offspring; but it is sex dependent. Dam PUFA supplementation increases wether growth. Supplementation with EPA and DHA to pregnant ewes and to their offspring after weaning showed a treatment interaction in mRNA concentration of hypothalamic neuropeptides associated with dry matter intake (DMI) regulation. A dose increased in EPA and DHA in pregnant ewe diets shows a linear increase in growth, but a quadratic change in DMI or feed efficiency; growth was associated with a linear increase in plasma glucose concentration and a linear decrease in plasma ghrelin concentration. In lambs born from ewes supplemented with different sources of FA during a glucose tolerance test; males’ plasma insulin concentration increased as FA unsaturation degree increased in the dam diet, the opposite happened with females’ plasma insulin concentration. Recent data from our lab showed that the supplementation with EPA and DHA during the last third of gestation to pregnant ewes increased liver and small intestine global DNA methylation and small intestine transporters for amino acids in the fetus. Despite EPA and DHA during late gestation increase growth in the offspring; when EPA and DHA were supplemented in early gestation, offspring growth was lesser that lambs born from ewes supplemented a saturated and monounsaturated lipid. The reason for the difference in results it is not clear. However, more studies focusing in some aspect of the biology will help to understand what specific fatty acid needs to be supplemented at different stages of gestation to improve offspring growth.

scholarly journals Fatty Acid Synthetase Activity in Mycobacterium phlei: Regulation by Polysaccharides

1971 ◽  
Vol 68 (1) ◽  
pp. 87-91 ◽  
Author(s):  
M. Ilton ◽  
A. W. Jevans ◽  
E. D. McCarthy ◽  
D. Vance ◽  
H. B. White ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthetase ◽  
Synthetase Activity ◽  
Mycobacterium Phlei ◽  
Fatty Acid Synthetase Activity

Évolution de la teneur en lipides de Leptosphaeria typhae en fonction de sa croissance et de sa reproduction sexuée : activité de synthèse et étude des lipides neutres et polaires

1985 ◽  
Vol 63 (12) ◽  
pp. 2460-2467
Author(s):  
Gérard Vidal
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acids ◽  
Lipid Content ◽  
Neutral Lipids ◽  
Fatty Acid Synthetase ◽  
Polar Lipids ◽  
Synthetase Activity ◽  
Lipid Turnover ◽  
Fatty Acid Synthetase Activity

When perithecia appear (on the 7th day of growth), the mycelial lipid content falls and the degree of fat insaturation increases; fatty acid synthetase activity greatly increases. Lipid turnover is therefore accelerated. Among neutral lipids, triglycerides constitute the largest pool and their proportion increases when perithecia appear. Free fatty acids also increase, confirming the lipid turnover's acceleration. Polar lipids especially disappear; the phosphatidylcholine/phosphatidylethanolamine ratio increases when the fungus ascosporulates.

scholarly journals Modification of mammalian fatty acid synthetase activity by NADP

FEBS Letters ◽  
1985 ◽  
Vol 189 (2) ◽  
pp. 231-234 ◽  
Author(s):  
Stuart Smith ◽  
Tracy Linn ◽  
Alan Stern
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthetase ◽  
Synthetase Activity ◽  
Fatty Acid Synthetase Activity
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