The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis

2016 ◽  
Vol 473 (4) ◽  
pp. 449-461 ◽  
Author(s):  
Koichiro Kawaguchi ◽  
Ayumi Kinameri ◽  
Shunsuke Suzuki ◽  
Shogo Senga ◽  
Youqiang Ke ◽  
...  

The DNA methylation status of CpG islands in the FABP5 promoter is critical for its expression. Epigenetic regulation of FABP5 gene expression plays an important role during human prostate carcinogenesis, along with up-regulation of c-Myc and Sp1.

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