Correlation between Methylenetetrahydrofolate Reductase Polymorphisms and Hepatocellular Carcinoma: A Meta-Analysis

2019 ◽  
Vol 74 (3) ◽  
pp. 251-256 ◽  
Author(s):  
Hailong Su ◽  
Guo Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Polymorphisms ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Random Effect ◽  
Recessive Model ◽  
Mthfr Gene ◽  
Systematic Research ◽  
The Relationship ◽  
Random Effect Models

Background: The correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and hepatocellular carcinoma (HCC) remains controversial. Objectives: We performed this study to better assess the relationship between MTHFR gene polymorphisms and the likelihood of HCC. Methods: A systematic research of PubMed, Medline, and Embase was performed to retrieve relevant articles. ORs and 95% CIs were calculated. Results: A total of 15 studies with 8,378 participants were analyzed. In overall analyses, a significant association with the likelihood of HCC was detected for the rs1801131 polymorphism with fixed-effect models (FEMs) in recessive comparison (p = 0.002, OR 0.62, 95% CI 0.43–0.82). However, no positive results were detected for the rs1801133 polymorphism in any comparison. Further subgroup analyses revealed that the rs1801131 polymorphism was significantly associated with the likelihood of HCC in Asians with both FEMs (recessive model: p < 0.0001, OR 0.42, 95% CI 0.29–0.62; allele model: p = 0.004, OR 1.20, 95% CI 1.06–1.35) and random-effect models (recessive model: p = 0.002, OR 0.47, 95% CI 0.29–0.75). Nevertheless, we failed to detect any significant correlation between the rs1801133 polymorphism and HCC. Conclusions: Our findings indicated that the rs1801131 polymorphism may serve as a genetic biomarker of HCC in Asians.

scholarly journals Methylenetetrahydrofolate reductase C677T (Ala>Val, rs1801133 C>T) polymorphism decreases the susceptibility of hepatocellular carcinoma: a meta-analysis involving 12,628 subjects

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Sheng Zhang ◽  
Jiakai Jiang ◽  
Weifeng Tang ◽  
Longgen Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Case Control ◽  
Recessive Model ◽  
Case Control Studies ◽  
Independent Case ◽  
Synonymous Variant ◽  
Relationship Of ◽  
The Relationship

Abstract C677T (Ala&gt;Val, rs1801133 C&gt;T), a non-synonymous variant of methylenetetrahydrofolate reductase (MTHFR) gene, has been found to be associated with an impair enzyme activity of MTHFR. The relationship of MTHFR rs1801133 with hepatocellular carcinoma (HCC) has been extensively investigated. However, the findings were conflicting. Recently, more investigations have been conducted on the relationship of MTHFR rs1801133 with HCC. To obtain a more precise assessment on the effect of this non-synonymous variant to the development of HCC, a pooled-analysis was performed. This meta-analysis consisted of 19 independent case–control studies. By using the odds ratio (OR) combined with 95% confidence interval (CI), the relationship of MTHFR rs1801133 with HCC risk was determined. A total of 19 independent case–control studies were included. Finally, 6,102 HCC cases and 6,526 controls were recruited to examine the relationship of MTHFR rs1801133 with HCC risk. In recessive model (TT vs. CC/CT), the findings reached statistical significance (OR, 0.90; 95%CI, 0.82–0.98; P = 0.016). Subgroup analysis also found an association between MTHFR rs1801133 polymorphism and the decreased risk of HCC in hepatitis/virus related patients (recessive model: OR, 0.85; 95%CI, 0.72–0.99; P = 0.035, and allele model: OR, 0.90; 95%CI, 0.81–0.99; P = 0.028). Subgroup analyses indicated that extreme heterogeneity existed in Asian population, larger sample size investigation, hospital-based study and normal/healthy control subgroups. The shape of Begger’s seemed symmetrical. Egger’s linear regression test also confirmed these evaluations. Sensitivity analyses suggested that our findings were stable. In summary, our results highlight that MTHFR rs1801133 polymorphism decreases HCC susceptibility. The relationship warrants a further assessment.

scholarly journals Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

2020 ◽  
Vol 20 (1) ◽  
pp. 351-358
Author(s):  
Yingwei Wang ◽  
Peiyang Hu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Meta Analysis ◽  
Group Analysis ◽  
Interleukin 10 ◽  
Recessive Model ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Keywords Hepatocellular Carcinoma ◽  
Relationship Of ◽  
The Relationship

Background: Inconsistent results have been reported from studies investigating the relationship of the interleukin-10 (IL-10) -1082 G/A polymorphism and the susceptibility of hepatocellular carcinoma (HCC). Therefore, a thorough literature review of relatedstudies was performed in this meta-analysis to examine the association of the interleukin-10(IL-10) -1082 G/A poly- morphism with HCC susceptibility. Methods: Electronic databases were searched for literature on the relationship between interleukin-10(IL-10) -1082 G/A poly- morphism and the risk of HCC in accordance with the inclusion and exclusion criteria. The selected studies were analyzed using the Stata 12.0 software. Finally, the strength of the associations was evaluated using the odds ratio (OR) and 95% confidence intervals (95% CI). Results: A total of six case-control studies were enrolled into the current meta-analysis, which included a total of 911 patients and 1889 control subjects. Our data revealed no association between the IL-10 -1082 G/A polymorphism and the risk of HCC (GG vs AA:OR=0.84, 95%CI=0.57-1.25; AG vs AA:OR=0.85, 95%CI=0.70-1.05; Dominant model: OR=0.85, 95%CI=0.70- 1.03; and Recessive model: OR=0.92, 95%CI = 0.64-1.32). Similarly, no association was found in sub-group analysis based on ethnicity. Conclusion: The results of our study suggest no association between IL-10 -1082 G/A polymorphism and the risk of HCC. Keywords: Hepatocellular carcinoma; IL-10 polymorphism; risk analysis. 

Abstract 718: The Association of Erectile Dysfunction with Carotid Intima Media Thickness and Endothelial Dysfunction: A Meta-Analysis

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Bryan D Vo ◽  
Ehimen Aneni ◽  
Ebenezer Oni ◽  
Wazim Maziak ◽  
Theodore Feldman ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Meta Analysis ◽  
Random Effect ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Individual Participant Data ◽  
Media Thickness ◽  
Individual Participant ◽  
The Relationship ◽  
Random Effect Models

Introduction: A recent meta-analysis showed that erectile dysfunction (ED) was associated with elevated cardiovascular disease (CVD) mortality. However, findings from studies examining the relationship between ED and sub-clinical CVD have been conflicting. This study summarizes the current evidence related to the association of ED and vascular disease as measured by flow mediated dilation (FMD) of the endothelium and carotid intima media thickness (CIMT). Methods: We searched multiple internet databases for published literature on studies assessing the association of ED and FMD, and CIMT between 1964 and 2014. A total of 11 studies met the inclusion criteria for examining the association between ED and FMD, while 7 studies met criteria for assessing the association with CIMT. Fixed-effect and random-effect models were used to assess and compare the standardized mean difference (SMD) of FMD and CIMT between persons with and without ED. Results: From a total of 795 individual participant data (590 with and 205 without ED), persons with ED had a 0.66mm (0.49, 0.83) increase in CIMT by fixed effects model or 0.67mm (0.44, 0.90) by random effects model compared to those without ED. Similarly, from 1055 individual participant data (536 with and 419 without ED), ED was associated with a significant reduction in FMD by both fixed effect (-1.10% (95% CI: -2.10, -0.95)) and random effect models (-1.53% (95% CI: -2.10, -0.95)). There was significant heterogeneity among studies assessing the relationship between ED and FMD (I2 = 93.2%, p<0.001) but not among those comparing CIMT among persons with ED (I2 = 43.5% p=0.09). Conclusion: This study confirms that ED is associated with both worsening endothelial function and increased CIMT. Thus, worsening vascular function may be a pathogenic mechanism for increased CVD morbidity and mortality in persons with ED. A diagnosis of ED should prompt a thorough CV work-up and aggressive preventive management.

scholarly journals The roles of MTRR and MTHFR gene polymorphisms in congenital heart diseases: a meta-analysis

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Aiping Xu ◽  
Weiping Wang ◽  
Xiaolei Jiang
Keyword(s):  
Gene Polymorphisms ◽  
Congenital Heart ◽  
Methylenetetrahydrofolate Reductase ◽  
Heart Diseases ◽  
Meta Analysis ◽  
Mthfr Gene ◽  
Methionine Synthase ◽  
Congenital Heart Diseases ◽  
Methionine Synthase Reductase ◽  
Study Participants

Background: We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms with the risk of congenital heart diseases (CHD). Methods: Eligible articles were searched in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations of MTHFR and MTRR gene polymorphisms with CHD. Results: A total of 47 eligible studies were finally included in our meta-analysis. Our overall analyses suggested that MTRR rs1801394, MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms were all significantly associated with the risk of CHD in certain genetic models. Further subgroup analyses according to ethnicity of study participants demonstrated that the MTRR rs1801394 polymorphism was significantly correlated with the risk of CHD only in Asians, whereas MTRR rs1532268, MTHFR rs1801133 and MTHFR rs1801131 polymorphisms were significantly correlated with the risk of CHD in both Asians and Caucasians. Conclusions: Our findings indicated that MTRR rs1532268, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms may affect the risk of CHD in Asians and Caucasians, while the MTRR rs1801394 polymorphism may only affect in risk of CHD in Asians.

scholarly journals The Association between MTHFR Gene Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56070 ◽  
Author(s):  
Xue Qin ◽  
Qiliu Peng ◽  
Zhiping Chen ◽  
Yan Deng ◽  
Shan Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mthfr Gene ◽  
Carcinoma Risk

scholarly journals Meta-Analysis of miRNA Variants Associated with Susceptibility to Autoimmune Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Jun Zhang ◽  
Handan Tan ◽  
Qingfeng Cao ◽  
Guannan Su ◽  
Peizeng Yang
Keyword(s):  
Autoimmune Disease ◽  
Fixed Effects ◽  
Risk Allele ◽  
Meta Analysis ◽  
Random Effect ◽  
Significant Risk ◽  
Population Based ◽  
The Relationship ◽  
Random Effect Models ◽  
Allele Model

Purpose. Various studies have shown an association between miRNA polymorphisms and susceptibility to autoimmune disease (AD); however, the results are inconclusive. To evaluate whether miRNA polymorphisms account for a significant risk of AD, a total of 87 articles, including 39431 patients and 56708 controls, were identified to estimate their association with 12 AD subtypes. Methods. Several electronic databases were searched to analyze population-based studies on the relationship between miRNA variants and AD risk. Fixed effects or random effect models were used in the meta-analysis for the risk assessment. Results. In our meta-analysis, miR-146a rs2910164/rs57095329 conferred a marginally elevated risk for AD (allele model, OR = 1.08 , 95% CI: 1.01-1.15, P = 0.019 ; allele model, OR = 1.09 , 95 CI: 1.05-1.15, P < 0.001 , respectively). Furthermore, miR-196a2 rs11614913 was also associated with AD risk (allele model, OR = 0.92 , 95% CI: 0.88-0.97, P = 0.001 ) as well as miR-499 rs3746444 (allele model, OR = 1.16 , 95% CI: 1.03-1.29, P = 0.011 ). In addition, associations were observed between miR-149 rs2292832/miR-27a rs895819 and AD susceptibility in the overall population (allele model, OR = 1.15 , 95% CI: 1.06-1.24, P < 0.001 ; allele model, OR = 1.11 , 95% CI:1.01-1.22, P = 0.043 , respectively). Conclusions. Evidence from our systematic review suggests that miR-146a, miR-196a2, miR-499, miR-149, and miR-27a polymorphisms are associated with susceptibility to AD.

scholarly journals Effect of MTHFR A1298C and MTRR A66G genetic mutations on homocysteine levels in the Chinese population: a systematic review and meta-analysis

2017 ◽  
Vol 5 (4) ◽  
pp. 220-229 ◽  
Author(s):  
Jiancheng Wang ◽  
Nengtai Ouyang ◽  
Long Qu ◽  
Tengfei Lin ◽  
Xianglin Zhang ◽  
...  
Keyword(s):  
Chinese Population ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Random Effect ◽  
Mthfr Gene ◽  
Folate Intake ◽  
Folic Acid Fortification ◽  
Mthfr A1298c ◽  
Methionine Synthase Reductase ◽  
Mtrr A66g

AbstractBackground and ObjectivesThe Chinese population typically has inadequate folate intake and no mandatory folic acid fortification. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Hcy has been implicated in the pathogenesis of cardiovascular disease. We conducted a meta-analysis to assess whether the MTHFR gene A1298C and the MTRR gene A66G polymorphisms affect Hcy levels in the Chinese population.MethodsThis analysis included 13 studies with Hcy levels reported as one of the study measurements. Summary estimates of weighted mean differences and 95% confidence intervals (CIs) were obtained using random-effect models.ResultsOverall, there were no significant differences in Hcy concentrations between participants with the MTHFR 1298 CC (12 trials,n= 129), AA (n= 2166; β, −0.51 μmol/L; 95%CI: −2.14, 1.11;P= 0.53), or AC genotype (n= 958; β, 0.55 μmol/L; 95%CI: −0.72, 1.82;P= 0.40). Consistently, compared to those with the MTRR 66 GG genotype (6 trials,n= 156), similar Hcy concentrations were found in participants with the AA (n= 832; β, −0.43 μmol/L; 95%CI: −1.04, 0.17;P= 0.16) or AG (n=743; β, −0.57 μmol/L; 95%CI: −1.46, 0.31;P= 0.21) genotype. Similar results were observed for the dominant and recessive models.ConclusionsNeither the MTHFR A1298C polymorphism nor the MTRR A66G polymorphism affects Hcy levels in the Chinese population.

scholarly journals Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

2020 ◽  
Author(s):  
Citrawati Dyah Kencono Wungu ◽  
Fis Citra Ariyanto ◽  
Gwenny Ichsan Prabowo ◽  
Soetjipto Soetjipto ◽  
Retno Handajani
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Abstract Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk. Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.

scholarly journals Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

2020 ◽  
Author(s):  
Citrawati Dyah Kencono Wungu ◽  
Fis Citra Ariyanto ◽  
Gwenny Ichsan Prabowo ◽  
Soetjipto Soetjipto ◽  
Retno Handajani
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Abstract Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk. Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67; CA/AA vs CC, OR=1.19, 95% CI=1.03-1.36). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (G vs A, OR=1.98, 95% CI=1.62-2.42; AA/GA vs GG, OR=1.95, 95% CI=1.53-2.49; GG/GA vs AA, OR=2.52, 95% CI=1.69-3.76; AA vs GG, OR=3.14, 95% CI=2.06-4.79; and GA vs GG, OR=2.07, 95% CI=1.60-2.68), and -238 G/A (A vs G, OR=1.50, 95% CI=1.16-1.94; AA vs GG, OR=3.87, 95% CI=1.32-11.34; GA/GG vs AA, OR=2.67, 95% CI=1.17-6.10). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk. Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.

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