scholarly journals Discussion of relationships among changes of pathological indicators, postoperative lymphedema of the upper limb, and prognosis of patients with breast cancer

2019 ◽  
Vol 39 (4) ◽  
Author(s):  
Xiping Zhang ◽  
Binbin Tang ◽  
Dehong Zou ◽  
Hongjian Yang ◽  
Enqi Qiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Upper Limb ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Expression Level ◽  
Ki 67 ◽  
Node Metastasis ◽  
Ptnm Stage

Abstract Objectives: The present study aimed to discuss the impacts of changes to pathological indicators of patients with breast cancer upon the incidence of postoperative lymphedema of the upper limb and prognosis. Methods: 2597 female patients with breast cancer who received surgical treatment in our hospital were enrolled in the present study to evaluate the incidence of these patients’ postoperative lymphedema of the upper limb. Results: For patients with breast cancer, the incidence of postoperative lymphedema of the upper limb was related to T stage of breast cancer, lymph node metastasis, the number of metastatic lymph nodes, pTNM stage, and pathological types of breast cancer (P<0.05). Lymph node metastasis was an independent risk factor of lymphedema of the upper limb; lymph node metastasis and Ki-67 expression level were independent factors that impacted pathologic complete response rate of neoadjuvant chemotherapies. Patients’ mortality was correlated to pathological and molecular subtypes, Ki-67 expression level, ER expression level, PR expression level, and pTNM stage (P<0.05), among which the pTNM stage, Ki-67 expression level, and PR expression level were independent factors that affected prognosis of patients with breast cancer. Conclusion: Patients with lymph node metastasis were more prone to lymphedema of the upper limb, while it was easier for those whose Ki-67 expression level was high and who were not subject to lymph node metastasis to get a pathological complete response after receiving neoadjuvant chemotherapies. The prognosis was poorer among patients whose progesterone receptors were negative and Ki-67 expression levels were high at the advanced pTNM stage.

miR-155 expression level changes might be associated with initial phases of breast cancer pathogenesis and lymph-node metastasis

2016 ◽  
Vol 16 (3) ◽  
pp. 385-394 ◽  
Author(s):  
Nina Petrović ◽  
Ana Kolaković ◽  
Aleksandra Stanković ◽  
Silvana Lukić ◽  
Ahmad Řami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Expression Level ◽  
Node Metastasis ◽  
Cancer Pathogenesis

scholarly journals Risk factors for lymph node metastasis in gastric neuroendocrine tumor: a retrospective study

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xianghui Li ◽  
Lihua Shao ◽  
Xiaofeng Lu ◽  
Zhengyang Yang ◽  
Shichao Ai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Lymph Node ◽  
Retrospective Study ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumor ◽  
Tumor Location ◽  
Expression Level ◽  
Ki 67 ◽  
Node Metastasis

Abstract Background Lymph node metastasis (LNM) plays a vital role in the determination of clinical outcomes in patients with gastric neuroendocrine tumor (G-NET). Preoperative identification of LNM is helpful for intraoperative lymphadenectomy. This study aims to investigate risk factors for LNM in patients with G-NET. Methods We performed a retrospective study involving 37 patients in non-LNM group and 82 patients in LNM group. Data of demographics, preoperative lab results, clinical–pathological results, surgical management, and postoperative situation were compared between groups. Significant parameters were subsequently entered into logistic regression for further analysis. Results Patients in LNM group exhibited older age (p = 0.011), lower preoperative albumin (ALB) (p = 0.003), higher carcinoembryonic antigen (CEA) (p = 0.020), higher International normalized ratio (p = 0.034), longer thrombin time (p = 0.018), different tumor location (p = 0.005), higher chromogranin A positive rate (p = 0.045), and higher Ki-67 expression level (p = 0.002). Logistic regression revealed ALB (p = 0.043), CEA (p = 0.032), tumor location (p = 0.013) and Ki-67 (p = 0.041) were independent risk factors for LNM in G-NET patients. Conclusions ALB, CEA, tumor location, and Ki-67 expression level correlate with the risk of LNM in patients with G-NET.

Expression and prognostic significance of ECT2 in invasive breast cancer

2017 ◽  
Vol 71 (5) ◽  
pp. 442-445 ◽  
Author(s):  
Hong-kun Wang ◽  
Jian-fang Liang ◽  
Hui-xia Zheng ◽  
Hong Xiao
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Triple Negative ◽  
Prognostic Significance ◽  
High Expression ◽  
Proliferation Index ◽  
Ki 67 ◽  
Node Metastasis

AimsTo investigate the expression of epithelial cell transforming sequence 2 (ECT2) in invasive breast cancer and its prognostic significance.MethodsECT2 immunohistochemical detection was performed in 165 breast cancer specimens and 100 normal control tissues. Univariable and multivariable Cox proportional hazards regression model analysis was used to confirm independent prognostic factors. The PHREG procedure linear hypotheses testing method was used to analyse survival data.ResultsExpression of ECT2 in breast cancer was significantly higher than that of the normal control group (p<0.001), and it was related to tumour grade, the status of lymph node metastasis, TNM staging, recurrence status, menopausal status, and the Ki-67 proliferation index (p<0.05), and not related to age, tumour size, tumour type, expression of estrogen receptor, progesterone receptor and human epidermal growth factor 2, and triple-negative disease (p>0.05). Univariable analysis showed that expression of ECT2, the status of lymph node metastasis, triple-negative disease and Ki-67 proliferation index were related to the overall survival of patients with breast cancer (p<0.001, p=0.006, p=0.001, p=0.041, respectively). PHREG procedure linear hypotheses testing results for overall survival revealed that high expression of ECT2, lymph node metastasis, triple-negative disease and high Ki-67 proliferation index predicted lower overall survival rates. Multivariable Cox regression indicated that high expression of ECT2 and triple-negative disease were independent prognostic factors for patients with breast cancer (p<0.001, p=0.004, respectively).ConclusionsExpression of ECT2 may be one of the main causes of the occurrence and development of breast cancer, and high expression of ECT2 as an independent prognostic factor predicts a poor prognosis. ECT2 could also be a potential molecular target for designing therapeutic strategies for breast cancer.

Androgen Receptor and Enzymes in Lymph Node Metastasis and Cancer Reoccurrence in Triple-Negative Breast Cancer

2015 ◽  
Vol 30 (2) ◽  
pp. 184-189 ◽  
Author(s):  
Keely May McNamara ◽  
Tomomi Yoda ◽  
Yasuhiro Miki ◽  
Yasuhiro Nakamura ◽  
Takashi Suzuki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Androgen Receptor ◽  
Lymph Node Metastasis ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Ductal Carcinoma ◽  
University Hospital ◽  
Ki 67 ◽  
Node Metastasis

Background Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and HER2. TNBCs are a diverse subgroup, but one promising marker and therapeutic target of this breast cancer is the androgen receptor (AR). Previously we demonstrated that AR and cognate intracrine pathways are associated with decreased proliferation in invasive ductal carcinoma with their decrease also detected between organ-confined and invasive diseases. Therefore, in this study, we examined the status of AR and androgen-producing enzymes during the process of metastasis to lymph nodes and cancer recurrence. Materials and Methods We studied 2 series of patients with TNBC, one from Kumamoto University Hospital composed of 16 matched cases of primary and locally or distal recurrences and the other from Tohoku University Hospital examining 46 lymph node metastasis from 23 patients. In addition to studying concordance in AR expression, we also examined the interactions between AR and Ki-67 labeling index and AR and site of distal metastasis. Results In both series, AR status was concordant between primary and recurrent/metastatic disease, but coordinated expression of AR and androgenic enzymes was lost during the process. The inverse association between AR and Ki-67, previously reported in invasive ductal carcinoma (IDC), was markedly potentiated in both lymph node and recurrent cancers. In addition, AR expression appeared to have little effect on visceral metastasis but was associated directly with bone metastasis and inversely with brain metastasis. Conclusions The results of our present study demonstrated that AR remained in the majority of metastatic samples from AR-positive primary TNBCs and that AR manipulation could be exploited in the metastatic settings of TNBC.

scholarly journals Incidence of breast cancer and methylation of PCDH gene: a single ratio meta analysis of single rate

2021 ◽  
Author(s):  
Yu Liu ◽  
lili zhong ◽  
lixing wang ◽  
duohan zhang ◽  
chao zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Meta Analysis ◽  
Knowledge Network ◽  
Ki 67 ◽  
Methylation Rate ◽  
Node Metastasis ◽  
Cancer Group ◽  
Breast Cancer Group

IntroductionBreast cancer presents one of the highest rates of prevalence. With the development of genetics and biotechnology, we have learned that the occurrence and development of many cancers are closely related to abnormal gene expression. At present, some pieces of literature have reported that there may be a correlation between the expression of PCDH and the occurrence of breast cancer.Therefore, we selected some loci from PCDH gene to explore the correlation between the methylation of PCDH gene and breast cancer.Material and methodsThis research is a systematic review and critical appraisal, make a meta-analysis of prospective and retrospective cohort study. Research was conducted through computer Science, Wanfang and Chinese knowledge network databases PubMed, Embase and Network. In a literature search, seven cohort studies were identified. This I2 statistic is used to quantify heterogeneity. A fixed effect model was used to synthesize the results. Regression tests of linear funnel plot asymmetry were used to estimate potential publication bias.ResultsThe methylation rate of PCDH gene in breast cancer with lymph node metastasis was 75%, and that in breast cancer without lymph node metastasis was 70%. The methylation rate of PCDH gene was 75% in breast cancer group with high expression of the Ki-67 gene and 71% in breast cancer group with low expression of Ki-67 gene.ConclusionsAccording to previous studies, the positive rate of methylation of PCDH gene in breast cancer tissues is higher than that in adjacent tissues, and there is no obvious statistical difference in the correlation between lymphatic metastasis and Ki-67.

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