The association between dietary protein intake and esophageal cancer risk: a meta-analysis

Abstract Several papers studied dietary protein intake as a potential influence factor for esophageal cancer, but their findings were inconsistent. Thus, this meta-analysis was performed to identify the effect of protein intake on esophageal cancer risk. Potential case–control studies or cohort studies from the databases of Embase, Web of Science and PubMed were searched. The strength of association was quantified by pooling odds ratio (OR) and 95% confidence interval (CI). In total, 11 articles involving 2537 cases and 11432 participants were included in this meta-analysis. As a result, dietary protein intake had non-significant association on esophageal cancer risk overall (pooled OR = 1.11, 95% CI = 0.88–1.40). Meanwhile, we obtained consistent results in the subgroups analyses by study design, protein type, geographic locations and number of cases. Interestingly, dietary protein intake could significantly increase the risk of esophageal squamous cell carcinoma (pooled OR = 1.29, 95% CI = 1.02–1.62), instead of other disease type. To sum up, dietary protein intake had no significant association with esophageal cancer risk in the overall analysis; but, protein intake may be associated with the risk of esophageal squamous cell carcinoma. While some limitations existed in the present paper, more studies with large sample size are warranted to further confirm this result.

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225Association between phytosterol consumption esophageal cancer risk

International Journal of Epidemiology ◽

10.1093/ije/dyab168.396 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Xudong Liu ◽

Liping Sun ◽

Wenjing Zhao

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Cancer ◽

Cancer Risk ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Chinese Population ◽

Epidemiological Studies ◽

Inverse Association ◽

Logistic Regression Models

Abstract Background Phytosterols have anticancer effects and have been shown to inhibit various forms of cancer. However, epidemiological studies on the relationship between phytosterols and esophageal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to esophageal squamous cell carcinoma (ESCC) in the Chinese population. Methods A case–control study was conducted from July 2011 to June 2013, recruiting 856 eligible ESCC cases plus 856 controls. Dietary information was collected by using a validated food frequency questionnaire. The OR and 95% CI of ESCC risk were assessed by multivariable logistic regression models. Results The total phytosterols was found to be associated with a 56% (95% CI: 0.32- 0.61) reduction in ESCC risk when comparing the highest with the lowest tertiles, after adjusting for various confounders. An inverse association was also found between the consumption of β-sitostanol, β-sitosterol, campesterol and ESCC risk. No statistically significant association was found between rapesanol and ESCC risk. Conclusions These data indicated that the consumption of total phytosterols, β-sitostanol, β-sitosterol, campesterol is inversely associated with ESCC risk in a Chinese population Key messages Phytosterols consumption may contribute to the prevention of esophageal squamous cell carcinoma

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Faculty Opinions recommendation of Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717961987.793468751 ◽

2013 ◽

Author(s):

David Katzka

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Meta Analysis ◽

Prognostic Significance ◽

Over Expression

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Clinicopathological and prognostic significance of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma: a meta-analysis

Tumor Biology ◽

10.1007/s13277-013-1579-0 ◽

2014 ◽

Vol 35 (5) ◽

pp. 4401-4409 ◽

Cited By ~ 17

Author(s):

Wei Ping ◽

Wei Sun ◽

Yukun Zu ◽

Wenshu Chen ◽

Xiangning Fu

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Meta Analysis ◽

Hypoxia Inducible Factor ◽

Prognostic Significance ◽

Hypoxia Inducible Factor 1Α

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Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features

BioMed Research International ◽

10.1155/2017/1204082 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Shirui Chen ◽

Kai Zhou ◽

Liguang Yang ◽

Guohui Ding ◽

Hong Li

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Cancer ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Racial Differences ◽

Squamous Cell ◽

Geographic Location ◽

Molecular Features ◽

Genome Wide ◽

White Patients

The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer.

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