Free-oxygen radical generation in ischaemic rat intestine using a tissue section chemiluminescent assay

1987 ◽  
Vol 15 (2) ◽  
pp. 289-289 ◽  
Author(s):  
JOHN P. LAVELLE ◽  
PATRICK B. COLLINS ◽  
ALAN H. JOHNSON ◽  
THOMAS F. GOREY
Keyword(s):  
Tissue Section ◽  
Oxygen Radical ◽  
Rat Intestine ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Radical Generation

The Association Between Alterations in Redox Homeostasis, Cortisol, and Commonly Used Objective and Subjective Markers of Fatigue in American Collegiate Football

2021 ◽  
pp. 1-7
Author(s):  
Benjamin A. McKay ◽  
Jace A. Delaney ◽  
Andrew Simpkin ◽  
Theresa Larkin ◽  
Andrew Murray ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
College Football ◽  
Oxygen Radical ◽  
Flight Time ◽  
Stress Index ◽  
Strength Index ◽  
Urinary Cortisol ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Oxidative Stress Index

Purpose: To assess associations between a free oxygen radical test (FORT), free oxygen radical defense test (FORD), oxidative stress index, urinary cortisol, countermovement jump (CMJ), and subjective wellness in American college football. Methods: Twenty-three male student athlete American college football players were assessed over 10 weeks: off-season conditioning (3 wk), preseason camp (4 wk), and in season (3 wk). Assessments included a once-weekly FORT and FORD blood sample, urinary cortisol sample, CMJ assessment including flight time, reactive strength index modified and concentric impulse, and a daily subjective wellness questionnaire. Linear mixed models analyzed the effect of a 2 within-subject SD change in the predictor variable on the dependent variable. The effects were interpreted using magnitude-based inference and are presented as standardized effect size (ES) ± 90% confidence intervals. Results: Small negative associations were observed between FORT–flight time, FORT–fatigue, FORT–soreness (ES range = −0.30 to −0.48), FORD–sleep (ES = 0.42 ± 0.29), and oxidative stress index soreness (ES = 0.56 ± 0.29). Small positive associations were observed between FORT–cortisol (ES = 0.36 ± 0.35), FORD–flight time, FORD reactive strength index modified and FORD–soreness (0.37–0.41), oxidative stress index concentric impulse (ES = 0.37 ± 0.28), and with soreness–concentric impulse, soreness–flight time, and soreness reactive strength index modified (0.33–0.59). Moderate positive associations were observed between cortisol–concentric impulse and cortisol–sleep (0.57–0.60). Conclusion: FORT/FORD was associated with CMJ variables and subjective wellness. Greater amounts of subjective soreness were associated with decreased CMJ performance, increased FORT and cortisol, and decreased FORD.

scholarly journals Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell

Hepatology ◽  
1990 ◽  
Vol 11 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Prakash N. Rao ◽  
Thomas R. Walsh ◽  
Leonard Makowka ◽  
Randy S. Rubin ◽  
Thomas Weber ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Purine Nucleoside Phosphorylase ◽  
Oxygen Radical ◽  
Purine Nucleoside ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Nucleoside Phosphorylase

ABSTRACT

PEDIATRICS ◽  
1996 ◽  
Vol 97 (6) ◽  
pp. 870-870
Keyword(s):  
Free Radicals ◽  
Intestinal Bacteria ◽  
Oxygen Radical ◽  
Oral Iron ◽  
Oxygen Scavengers ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Malnourished Children ◽  
Iron Deficient ◽  
Low Levels

This article addresses the unsettled controversy about the use of iron in the treatment of children with malnutrition. Although many malnourished children are iron-deficient, there are at least two reasons why oral iron may be detrimental: 1) low levels of transferrin are common in such children which decreases the absorption of oral iron, thus promoting the growth of intestinal bacteria; and 2) iron that is absorbed, but which remains unbound, is converted from the ferrous to the ferric state and becomes an aggressive and potentially damaging free oxygen radical. The authors used the bleomycin assay to quantify the free or loosely bound iron in 50 children with kwashiorkor and compared this data with that found in six children with marasmus and 12 well-nourished children. Nonprotein-bound iron was found in 58% of the children with kwashiorkor, but in none of the others. Many children who are malnourished are deficient in micronutrients, such as vitamins A and E, zinc, and glutathione, which serve as free oxygen scavengers. An imbalance in free radicals and their scavengers results in tissue damage and potentially increases the morbidity and mortality in these precarious children. If the finding of these investigators is substantiated, it will add credence to the argument advising caution in respect to oral iron therapy in children with kwashiorkor.

scholarly journals Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure

2005 ◽  
Vol 26 (15) ◽  
pp. 1544-1550 ◽  
Author(s):  
Virginie Mellin ◽  
Marc Isabelle ◽  
Alexandra Oudot ◽  
Catherine Vergely-Vandriesse ◽  
Christelle Monteil ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiac Function ◽  
Oxygen Radical ◽  
Free Oxygen Radical ◽  
Free Oxygen

Determination of ethane and pentane in free oxygen radical-induced lipid peroxidation

Lipids ◽  
1989 ◽  
Vol 24 (2) ◽  
pp. 157-159 ◽  
Author(s):  
O. M. Pitkänen ◽  
M. Hallman ◽  
S. M. Andersson
Keyword(s):  
Lipid Peroxidation ◽  
Oxygen Radical ◽  
Free Oxygen Radical ◽  
Free Oxygen

scholarly journals Effects of exercise on alterations in redox homeostasis in elite male and female endurance athletes using a clinical point-of-care test

2016 ◽  
Vol 41 (10) ◽  
pp. 1026-1032 ◽  
Author(s):  
Nathan A. Lewis ◽  
Colin Towey ◽  
Georgie Bruinvels ◽  
Glyn Howatson ◽  
Charles R. Pedlar
Keyword(s):  
Oxidative Stress ◽  
Maximal Exercise ◽  
Point Of Care ◽  
Redox Homeostasis ◽  
Oxygen Radical ◽  
Endurance Athletes ◽  
Free Oxygen Radical ◽  
Free Oxygen ◽  
Male And Female ◽  
Clinical Point

Exercise causes alterations in redox homeostasis (ARH). Measuring ARH in elite athletes may aid in the identification of training tolerance, fatigued states, and underperformance. To the best of our knowledge, no studies have examined ARH in elite male and female distance runners at sea level. The monitoring of ARH in athletes is hindered by a lack of reliable and repeatable in-the-field testing tools and by the rapid turnaround of results. We examined the effects of various exercise intensities on ARH in healthy (non-over-reached) elite male and female endurance athletes using clinical point-of-care (POC) redox tests, referred to as the free oxygen radical test (FORT) (pro-oxidant) and the free oxygen radical defence (FORD) (antioxidant). Elite male and female endurance athletes (n = 22) completed a discontinuous incremental treadmill protocol at submaximal running speeds and a test to exhaustion. Redox measures were analyzed via blood sampling at rest, warm-up, submaximal exercise, exhaustion, and recovery. FORD was elevated above rest after submaximal and maximal exercise, and recovery (p < 0.05, d = 0.87–1.55), with only maximal exercise and recovery increasing FORT (p < 0.05, d = 0.23–0.32). Overall, a decrease in oxidative stress in response to submaximal and maximal exercise was evident (p < 0.05, d = 0.46). There were no gender differences for ARH (p > 0.05). The velocity at lactate threshold (vLT) correlated with the FORD response at rest, maximal exercise, and recovery (p < 0.05). Using the clinical POC redox test, an absence of oxidative stress after exhaustive exercise is evident in the nonfatigued elite endurance athlete. The blood antioxidant response (FORD) to exercise appears to be related to a key marker of aerobic fitness: vLT.

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