DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy
2007 ◽
Vol 35
(5)
◽
pp. 1352-1354
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Keyword(s):
DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often mutated or inactive in tumours. Here, we discuss how such deficiencies can in turn be exploited for cancer therapy.
2009 ◽
Vol 37
(3)
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pp. 605-613
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2005 ◽
Vol 25
(4)
◽
pp. 1526-1536
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2018 ◽
Vol 46
(6)
◽
pp. 1643-1651
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