Studies on the Sympathetic Control of Normal and Diseased Synovial Blood Vessels: The Effect of α and β Receptor Stimulation and Inhibition, Monitored by the 133Xenon Clearance Technique

1971 ◽  
Vol 40 (2) ◽  
pp. 197-209 ◽  
Author(s):  
W. C. Dick ◽  
R. Jubb ◽  
W. W. Buchanan ◽  
J. Williamson ◽  
K. Whaley ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clearance Rate ◽  
Qualitative Difference ◽  
Normal Subjects ◽  
Indirect Measure ◽  
Sympathetic Control ◽  
Blocking Agents ◽  
Disappearance Curve ◽  
Β Receptor ◽  
T Values

1. The half-life (T½) of the disappearance curve of 133Xe from the knee joint has been used as an indirect measure of synovial perfusion. 2. The effects of intra-articularly administered isoprenaline and noradrenaline and their respective blocking agents, propranolol and phentolamine, on the T½ values have been investigated in normal subjects and in patients with osteoarthritis and rheumatoid arthritis. 3. In normal subjects isoprenaline increased the clearance rate and this effect was blocked by propranolol. Noradrenaline decreased the clearance rate and this effect was blocked by phentolamine. 4. The injection of phentolamine in normal subjects caused an increase in synovial perfusion, suggesting the presence of a basal α-constrictor tone. 5. In the patients with osteoarthritis and rheumatoid arthritis quantitative differences were found in the responses to isoprenaline and noradrenaline and their respective blocking agents. 6. There appeared to be a qualitative difference in the case of phentolamine; it is possible that vasoconstrictor tone may be lost in inflamed joints.

Catabolism of Human Fibrinogen Fragment D in Normal Subjects and Patients with Liver Cirrhosis

1980 ◽  
Vol 44 (03) ◽  
pp. 146-149 ◽  
Author(s):  
Nicole Ardaillou ◽  
Jeannine Yvart ◽  
Philippe Le Bras ◽  
Marie-José Larrieu
Keyword(s):  
Liver Cirrhosis ◽  
Clearance Rate ◽  
Plasma Clearance ◽  
Normal Subjects ◽  
Fractional Catabolic Rate ◽  
Human Fibrinogen ◽  
Plasma Pool ◽  
Catabolic Rate ◽  
Chloramine T

SummaryThe catabolism of human fragment D, (FgD), obtained by plasmin digestion of fibrinogen has been investigated in normal subjects and patients with liver cirrhosis and the results compared with those obtained for fibrinogen (Fg). Fg was labelled with I-125 and Fg D with I-131 using the chloramine T method. The plasma disappearance curves of both labelled proteins fitted a two exponential curve. In controls the plasma clearance rate of Fg D was greater than that of Fg as shown by the marked difference between the half-lives of these two tracers: 8,9 and 83,5 hours for Fg D and Fg respectively. The fractional catabolic rate of Fg D was 3.38 times the plasma pool per day. In nine patients with liver cirrhosis, catabolism of Fg was not modified. In contrast, catabolism of Fg D was significantly reduced with a half life of 13.0 hours and a low fractional catabolic rate. These results suggest the role of the liver in the catabolism of Fg D in man.

scholarly journals Diet in Rheumatoid Arthritis versus Systemic Lupus Erythematosus: Any Differences?

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 772
Author(s):  
Alessia Alunno ◽  
Francesco Carubbi ◽  
Elena Bartoloni ◽  
Davide Grassi ◽  
Claudio Ferri ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Musculoskeletal Diseases ◽  
Normal Subjects ◽  
Experimental Models ◽  
Systemic Lupus ◽  
History Of ◽  
Indirect Action

In recent years, an increasing interest in the influence of diet in rheumatic and musculoskeletal diseases (RMDs) led to the publication of several articles exploring the role of food/nutrients in both the risk of developing these conditions in normal subjects and the natural history of the disease in patients with established RMDs. Diet may be a possible facilitator of RMDs due to both the direct pro-inflammatory properties of some nutrients and the indirect action on insulin resistance, obesity and associated co-morbidities. A consistent body of research has been conducted in rheumatoid arthritis (RA), while studies in systemic lupus erythematosus (SLE) are scarce and have been conducted mainly on experimental models of the disease. This review article aims to outline similarities and differences between RA and SLE based on the existing literature.

scholarly journals Cerebral MRI is necessary in patients with rheumatoid arthritis and uveitis before undergoing therapy with TNF-α blocking agents

Rheumatology ◽  
2005 ◽  
Vol 44 (11) ◽  
pp. 1373-1373 ◽  
Author(s):  
V. Limmroth ◽  
C. Thimm ◽  
T. Hudde ◽  
T. Fuchsluger ◽  
I. Wanke
Keyword(s):  
Rheumatoid Arthritis ◽  
Blocking Agents ◽  
Tnf Α ◽  
Cerebral Mri

Cytokine production from stimulated whole blood cultures in rheumatoid arthritis patients treated with various TNF blocking agents

2009 ◽  
Vol 20 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Calin Popa ◽  
Pilar Barrera ◽  
Leo A.B. Joosten ◽  
Piet L.C.M. van Riel ◽  
Bart-Jan Kullberg ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Whole Blood ◽  
Cytokine Production ◽  
Blood Cultures ◽  
Blocking Agents

scholarly journals Long-term effectiveness and safety of TNF-blocking agents in daily clinical practice: results from the Dutch Rheumatoid Arthritis Monitoring register

Rheumatology ◽  
2010 ◽  
Vol 50 (1) ◽  
pp. 196-203 ◽  
Author(s):  
W. Kievit ◽  
J. Fransen ◽  
E. M. M. Adang ◽  
A. A. den Broeder ◽  
H. J. Bernelot Moens ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Daily Clinical Practice ◽  
Blocking Agents

Isotope Studies in Normal and Diseased Knee Joints: 99mTc Uptake Related to Clinical Assessment and to Synovial Perfusion Measured by the 133Xe Clearance Technique

1971 ◽  
Vol 40 (4) ◽  
pp. 327-336 ◽  
Author(s):  
W. C. Dick ◽  
S. D. Deodhar ◽  
Carol J. Provan ◽  
G. Nuki ◽  
W. W. Buchanan
Keyword(s):  
Rheumatoid Arthritis ◽  
Normal Subjects ◽  
Knee Joints ◽  
133Xe Clearance ◽  
Normal Limits ◽  
Human Volunteers ◽  
Normal Human ◽  
Clinical Indices ◽  
Isotope Studies ◽  
The Mean

1. Uptake of intravenously administered radioactive technetium (99mTc) was measured over the knee joints in normal human volunteers, in patients with osteoarthritis and in groups of synovectomized and unoperated patients with rheumatoid arthritis. The uptake was compared with clinical indices of inflammation (pain, tenderness swelling and stiffness), and the clearance rate of intra-articularly injected radioactive xenon (133Xe). The 99mTc uptakes were found to be unrelated to the isotope dose and the day-to-day reproducibility was acceptable. 2. The mean uptake of 99mTc was within normal limits in osteoarthritis. Both in synovectomized and in unoperated rheumatoid arthritis 99mTc uptake was significantly higher than in normal subjects. 3. Of the clinical indices studied significant correlation of 99mTc uptake was found with pain and swelling in all groups of patients studied. 4. Faster clearance of 133Xe in unoperated rheumatoid arthritis correlated well with the higher 99mTc uptakes. 5. The results confirm that 99mTc uptakes are raised in inflammatory arthritis but not in degenerative arthritis. The relation of 99mTc uptake to the clinical indices of inflammation and to the 133Xe clearance from the joint is discussed.

In Vivo Catabolism of Human Fibrinogen Fragment D in Normal Subjects and Patients with Liver Cirrhosis

1979 ◽  
Author(s):  
N. Ardaillou ◽  
J. Yvart ◽  
M.J. Larrieu
Keyword(s):  
Liver Cirrhosis ◽  
Polyacrylamide Gel Electrophoresis ◽  
Normal Subjects ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Compartment System ◽  
Human Fibrinogen ◽  
Chloramine T ◽  
Disappearance Curve

The in vivo catabolism of purified 131-I-fragment D (Fg D) was studied in comparison with that of 125-I-Fibrinogen (Fg) simultaneously injected in 6 controls and 8 patients with liver cirrhosis. Fg D, M.W. 85,000, was obtained following prolonged (24 hours) plasmin digestion of human Fg. Labelling was performed using the chloramine T method. Linlabelled and labelled Fg and Fg D were characterized hy immunoelectrophoresis and SDS Polyacrylamide gel electrophoresis. Radioactivity was measured in thrombin-clottable (Fg) and TCA-precipitable (Fg D) proteins from plasma. Labelled Fg D present in plasma samples 1, 6 and 12 hours following injection eluted from Sephadex G 2D0 at the same position as native Fg D. A two compartment system was derived from the corresponding plasma disappearance curves for both Fg and Fg D in controls and patients. In controls, the first component of Fg D disappearance curve represented 54.1±13.4% of the total clearance with T 1/2 of 2.5±0.9 hours. The T 1/2 of the second component was 3.9±1.0 hours, Fg D disappeared more rapidly from plasma than Fg, and the ratio of Fg D to Fg was 0.11-0,02. In patients with liver cirrhosis, there was a significant (p<0.005) increase of T 1/2 of the second component (13.6±2.6 hours), whereas the in vivo survival of Fg was normal (4 cases) or decreased (2 cases). These results suggest that the liver interfers with the metabolic clearance rate of Fg D.

Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia

2007 ◽  
Vol 17 (5) ◽  
pp. 429-435 ◽  
Author(s):  
Chee Seng Hee ◽  
Suk Chyn Gun ◽  
Rakesh Naidu ◽  
Esha Gupta ◽  
Sushela Devi Somnath ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Nucleotide Polymorphisms ◽  
Gene Promoter ◽  
Normal Subjects ◽  
Interleukin 10 ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals The comparative effectiveness of tumor necrosis factor-blocking agents in patients with rheumatoid arthritis and patients with ankylosing spondylitis: A six-month, longitudinal, observational, multicenter study

2005 ◽  
Vol 52 (8) ◽  
pp. 2506-2512 ◽  
Author(s):  
Marte S. Heiberg ◽  
Bjørn-Yngvar Nordvåg ◽  
Knut Mikkelsen ◽  
Erik Rødevand ◽  
Cecilie Kaufmann ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Tumor Necrosis Factor ◽  
Multicenter Study ◽  
Comparative Effectiveness ◽  
Tumor Necrosis ◽  
Blocking Agents ◽  
Necrosis Factor
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