Effect of Benoxaprofen on Release of Slow-Reacting Substances from Human Lung Tissue In Vitro

1982 ◽  
Vol 63 (2) ◽  
pp. 219-221 ◽  
Author(s):  
V. Y. Lee ◽  
J. Margaret Hughes ◽  
J. P. Seale ◽  
Diana M. Temple
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Calcium Ionophore ◽  
Inhibitory Effects ◽  
Human Lung Tissue ◽  
Normal Human ◽  
Clinical Asthma

1. Macroscopically normal human lung tissue was obtained from operative specimens removed for lung cancer and challenged with antigen or calcium ionophore. The release of histamine and slow-reacting substances was measured by fluorimetric and bioassay techniques respectively. 2. Benoxaprofen, a drug with inhibitory effects on the lipoxygenase and cyclo-oxygenase pathways, caused a dose-related reduction of release of slow-reacting substances without affecting histamine release. 3. These results with human lung tissue in vitro suggest that benoxaprofen may be used to investigate the role of slow-reacting substances in experimental and clinical asthma.

Localization and activity of iNOS in normal human lung tissue and lung cancer tissue

2007 ◽  
Vol 22 (3) ◽  
pp. 226-231 ◽  
Author(s):  
L. Speranza ◽  
M.A. De Lutiis ◽  
Y.B. Shaik ◽  
M. Felaco ◽  
A. Patruno ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Cancer Tissue ◽  
Lung Cancer Tissue ◽  
Human Lung Tissue ◽  
Normal Human

scholarly journals AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status

Oncogene ◽  
2007 ◽  
Vol 27 (11) ◽  
pp. 1650-1656 ◽  
Author(s):  
F S Falvella ◽  
M Spinola ◽  
C Pignatiello ◽  
S Noci ◽  
B Conti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Disease Status ◽  
Mrna Levels ◽  
Human Lung Tissue ◽  
Cancer Disease ◽  
Normal Human

The Glucocorticosteroid, Budesonide, Partially Blocks Histamine Release from Human Lung Tissue in Vitro

Allergy ◽  
1986 ◽  
Vol 41 (5) ◽  
pp. 319-326 ◽  
Author(s):  
H. Bergstrand ◽  
B. Lundquist ◽  
B.-Å. Petersson
Keyword(s):  
Histamine Release ◽  
Lung Tissue ◽  
Human Lung ◽  
Human Lung Tissue

scholarly journals A labelled-ubiquicidin antimicrobial peptide for immediate in situ optical detection of live bacteria in human alveolar lung tissue

2015 ◽  
Vol 6 (12) ◽  
pp. 6971-6979 ◽  
Author(s):  
Ahsan R. Akram ◽  
Nicolaos Avlonitis ◽  
Annamaria Lilienkampf ◽  
Ana M. Perez-Lopez ◽  
Neil McDonald ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Lung Tissue ◽  
Human Lung ◽  
Optical Detection ◽  
Human Lung Tissue ◽  
Bacterial Detection ◽  
Live Bacteria

A fluorescently labelled ubiquicidin peptide enables bacterial detection in human lung tissuein vitro.

Light distribution in human lung tissue at 413.1 nm in vitro

1998 ◽  
Author(s):  
Zhiwei Huang ◽  
Chee T. Chia ◽  
Cheong Hoong Diong ◽  
Sing Lee ◽  
Wei-Ming Zheng ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Human Lung ◽  
Light Distribution ◽  
Human Lung Tissue

High-Resolution CT Findings of Leukemia Pulmonary Infiltration and Chemotherapy Outcome and In Vitro Study of Human Lung Tissue

2021 ◽  
Vol 11 (2) ◽  
pp. 360-369
Author(s):  
Caide Xie ◽  
Tianjing Zhao ◽  
Liang Fang
Keyword(s):  
High Resolution ◽  
Lung Tissue ◽  
Human Lung ◽  
Ct Imaging ◽  
Imaging Features ◽  
Human Lung Tissue ◽  
High Resolution Ct ◽  
Ct Findings ◽  
Pulmonary Infiltration

In order to explore the high-resolution CT findings of leukemia pulmonary infiltration and chemotherapy outcomes and the in vitro study of human lung tissue, this paper selected a total of 120 clinically or surgically confirmed leukemia patients at the designated hospital of the study from December 2014 to December 2018, and divided them into three groups according to the random number table method: pulmonary infiltration group, chemotherapy outcome group and in vitro study group, with 40 cases in each group. The CT imaging features of the three groups of patients were observed and summarized respectively; the anomalous evaluation indexes of pulmonary parenchyma tissue abnormalities included CT halo sign, air crescent sign, lung segment consolidation, bronchial vascular bundle and nodules; the CT abnormalities such as thickening of the interlobular septum, bronchial interstitial thickening, nodular shadow, ground glassy change, and air cavity consolidation were selected as observation indicators. The results show that all cases have multiple solid nodules or multiple plaques, varying in number, size and distribution, in which 13 cases have multiple patchy shadows, 9 cases have multiple knots and 11 cases have multiple plaques and nodules; lesions are mainly distributed along the bronchial vessels in 21 cases, and 9 cases are along the center of the small leaves and 5 cases are randomly distributed; there are 13 cases that have frosted glass, in which 4 cases with pleural effusion, 9 cases with mold infection, show multiple patchy shadows with halo signs and layered mold balls. In summary, leukemia pulmonary infiltration has polymorphic high-resolution CT findings and chemotherapy outcomes; high-resolution CT imaging and in vitro studies of human lung tissue have important clinical and pathological research value for leukemia infiltration and chemotherapy outcome. The results of this study provide a reference for the further researches on high-resolution CT findings of pulmonary infiltration and chemotherapy outcomes and in vitro studies of human lung tissue.

Elemental analyses in human lung tissue correlated with smoking, emphysema and lung cancer

1989 ◽  
Vol 19 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
P‐L. Kalliomäki ◽  
P. Kokkonen ◽  
P. Pääkkö ◽  
S. Anttila ◽  
K. Kalliomäki
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Human Lung Tissue ◽  
Elemental Analyses

scholarly journals Electron microscopic study of human lung tissue after in vitro exposure to elastase.

1993 ◽  
Vol 41 (6) ◽  
pp. 851-866 ◽  
Author(s):  
S M Morris ◽  
P J Stone ◽  
G L Snider
Keyword(s):  
Animal Models ◽  
Lung Tissue ◽  
Human Lung ◽  
Basement Membranes ◽  
Morphological Evidence ◽  
Elastic Fibers ◽  
Human Neutrophil Elastase ◽  
Human Lung Tissue ◽  
Thin Sections

Much of the experimental evidence supporting the hypothesis that pulmonary emphysema results from an imbalance between elastases and anti-elastases in the lung comes from animal models. The present study was designed to examine the effects on human lung tissue of the two elastases that have been most widely used to produce these animal models. Lung tissue was exposed in vitro to human neutrophil elastase (HNE) or porcine pancreatic elastase (PPE). Although both enzymes solubilized protein at similar rates, PPE solubilized elastin five times faster than did HNE. Ultrastructurally, HNE-exposed tissue exhibited fewer damaged elastic fibers as well as some fibers that were damaged at the edges, whereas the interior of the fiber appeared intact. Elastic fibers showing damage only at the periphery were not seen in tissue exposed to PPE. Immunocytochemical studies in which antibodies to HNE and PPE were applied to thin sections of Lowicryl-embedded tissue indicated that both of these elastases could be detected in association with elastic fibers, but only in areas of the fiber that showed morphological evidence of elastase injury. Both HNE and PPE removed fibronectin from basement membranes (as determined by loss of binding of fibronectin antibodies after exposure to elastase), but neither elastase was detected on basement membrane. Loss of epithelial cells usually accompanied elastic fiber damage by HNE but not PPE.

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